Navigation Links
Animal Study Links Social Standing With Drug Use Risk
Date:4/6/2008

Subordinate monkeys placed under stress more likely to choose cocaine over food

SUNDAY, April 6 (HealthDay News) -- Monkeys with lower social standing are more likely than dominant monkeys to choose cocaine over food when faced with a stressful situation, a new study finds.

The Wake Forest University School of Medicine researchers exposed four dominant and four subordinate male cynomolgus monkeys to a socially stressful situation. Each monkey was taken out of its home cage and placed in an unfamiliar cage surrounded by four unfamiliar animals. While the monkeys were physically safe, they could hear and see the aggressive behavior of the other monkeys.

PET scans of the monkeys' brains showed that the subordinate monkeys had pronounced decreased activity in areas of the brain involved with stress and anxiety (amygdala and hippocampus) and in emotional and social processing (anterior cingulate cortex). The dominant monkey showed increases in reward-related areas of the brain.

After being in an unfamiliar cage, the monkeys were given the opportunity to select between a lever that they knew delivered cocaine or one that delivered food. The subordinate monkeys were more likely than dominate monkeys to choose cocaine over food.

The study was to be presented Sunday at Experimental Biology 2008 in San Diego.

The findings may offer clues to the social context of drug use and addiction in humans, the researchers said.

"We believe this type of research can be used to identify better treatment strategies, including providing environmental enrichment, that may affect the likelihood of using drugs," Michael A. Nader, professor of physiology and pharmacology at Wake Forest, said in a prepared statement.

Nader noted that it's also important to understand distinct patterns of social stress-related brain activity that may increase attraction to cocaine in vulnerable people. Understanding these stress-related brain changes may also help in the development of treatment and prevention methods for people with disorders such as anxiety and depression that can be caused by chronic stress.

More information

The U.S. National Institute on Drug Abuse has more about drug abuse and addiction.



-- Robert Preidt



SOURCE: Wake Forest University Baptist Medical Center, news release, April 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Humans have more distinctive hearing than animals, Hebrew U study shows
2. Gamma Secretase Modulators Show Promise in Alzheimers Disease Animal Model Efficacy Studies, According to Research Conducted by TorreyPines Therapeutics
3. Folate scores a win in animal studies: Brief, high doses of B vitamin blunt damage from heart attack
4. Human, animal vaccine development goal of hepatitis E virus research
5. Pain Management For Your Pets, Key Information Every Pet Owner Should Know - Live Webcast to Pet Owners, March 13, 8:00 p.m. to 9:00 p.m. (EDT) Via Morris Animal Foundation
6. Pain Management For Pets, Key Strategies For Veterinarians - Live Webcast to Veterinarians, March 13, 7:00 p.m. to 8:00 p.m. (EDT) Via Morris Animal Foundation
7. Researchers create first chikungunya animal model
8. Animal Planet Pet Video to Provide 2 Million Free Training DVDs to New Pet Parents of Adopted Shelter Dogs and Cats
9. U.S. Seeks to Limit Animal Testing of Toxic Chemicals
10. Chicago Tribune Does Story on Canine Cancer, Morris Animal Foundation (MAF) Effort to Find a Cure - MAF Can Provide Information - Local Angles for a Feature Story
11. Photo: Animal Rescue League of Boston Receives $3 Million Grant to Establish a Center for Shelter Dogs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Animal Study Links Social Standing With Drug Use Risk
(Date:10/13/2017)... ... 13, 2017 , ... ProVest Insurance Group, a family managed ... Raleigh regions, is organizing an extended charity drive to benefit the family of ... , After struggling since birth with several health challenges, T.J. was later diagnosed ...
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association ... standards of excellence for the field of eating disorders, announces the opening of ... 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. , ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... viewers the lowdown on sciatica in a new episode of "Success Files," which ... current events and innovation and investigates each subject in-depth with passion and integrity. ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... now treating sleep apnea using cutting-edge Oventus O2Vent technology. As many ... sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer significant ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017 The Rebound mobile ... the struggle to reverse the tide of prescription drug addiction. ... regulating their medicine intake and stepping down their dosage in ... to launch in December 2017; the first 100,000 people to ... more at http://www.rebound-solution.com/ ...
(Date:9/27/2017)...  Commended for their devotion to personalized service, SMP Pharmacy ... one in the South Florida Business Journal,s 50 Fastest-Growing Companies, ... list, the national specialty pharmacy has found its niche.  To ... soon be honored by SFBJ as the 2017 Power Leader ... to receive his award in October, Bardisa said of the ...
(Date:9/25/2017)... 25, 2017  EpiVax, Inc., a leader in ... immune-engineering today announced the launch of EpiVax Oncology ... personalized therapeutic cancer vaccines. EpiVax has provided $500,000 ... to enabling technologies to the new precision immunotherapy ... EpiVax Oncology as Chief Executive Officer. Gad brings ...
Breaking Medicine Technology: