Navigation Links
Animal Study Explores Potential Gene Therapy for Depression
Date:10/20/2010

WEDNESDAY, Oct. 20 (HealthDay News) -- A combination of animal and human research is pointing the way towards a novel gene therapy that could ultimately help in the treatment of major depression, researchers say.

The approach is designed to boost levels of a brain protein known as p11. The study authors cite p11 as a key player in the promotion of feelings of reward, pleasure and satisfaction with positive life experiences.

"Current therapies for depression treat symptoms but not underlying causes, and while that works for many patients, those with advanced depression or depression that does not respond to medication could hopefully benefit from our new approach," study senior investigator Dr. Michael Kaplitt, an associate professor and vice chairman for research of neurological surgery at Weill Cornell Medical College, said in a news release from New York-Presbyterian Hospital/Weill Cornell Medical Center.

Kaplitt, who is also a neurosurgeon at New York-Presbyterian Hospital/Weill Cornell, and his colleagues published their findings in the Oct. 20 issue of Science Translational Medicine.

P11's central role in depression was uncovered in 2006 by Nobel Prize winner Dr. Paul Greengard of Rockefeller University. At that time, p11 was identified as a key player in facilitating the binding of the neurotransmitter serotonin -- long cited as a mood, appetite and sleep regulator -- to nerve cells.

"In the absence of p11, a neuron can produce all the serotonin receptors it needs, but they will not be transported to the cell surface and therefore won't stick out and latch on to the neurotransmitter," explained Kaplitt in the news release.

Following discussions with Greengard, Kaplitt further studied p11's role in mice by disabling the protein's ability to function properly in a specific part of the brain called the nucleus accumbens, which is known to be involved in both addiction and depression.

Without p11, the mice displayed depressive behaviors. The investigators then used a technique they had tested in Parkinson's disease patients, in which they engineer a non-functioning virus, pack it with a desired genetic "payload" (in this case, the p11 gene), and then direct the virus to deposit its contents into specifically targeted brain cells.

After the gene was delivered to the animals' p11-inhibited nucleus accumbens regions, the mice stopped displaying depressive behaviors, the researchers reported.

What's more, autopsies conducted on human patients who had been diagnosed with severe depression further revealed that the same region in their brains had significantly lower amounts of the p11 gene than typically found in patients with no signs of depression, the study noted.

"Together, these studies provide strong evidence that maintaining adequate levels of this particular protein, p11, in this pleasure-reward area of the brain may be central to preventing or treating depression," Kaplitt concluded.

However, "patients should not get their hopes up that this is going to turn around the treatment of depression anytime soon," according to Dr. Bernard Carroll, scientific director of the Pacific Behavioral Research Foundation in Carmel, Calif., and a former chairman of the U.S. Food and Drug Administration's advisory committee for psychotropic drugs.

"The laboratory findings are interesting, but the translational step to anything that would benefit a patient is very removed at this point," he noted. "Although the basic neurobiology that is being studied here is well known, depression is a human disorder and animal models do not faithfully reproduce the full syndrome. So while I'm not knocking the science, what I'm knocking is the rush to speculate about how far this will take us."

More information

For more on depression and treatment, visit the U.S. National Institute of Mental Health.

-- Alan Mozes

SOURCES: New York-Presbyterian Hospital/Weill Cornell Medical Center, news release, Oct. 20, 2010; Bernard Carroll, M.D., scientific director, Pacific Behavioral Research Foundation, Carmel, Calif.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. With magnetic nanoparticles, scientists remotely control neurons and animal behavior
2. Hallmark Alzheimers disease changes found in retinas of humans and imaged in live animals
3. Exercise May Combat Alcohol Cravings, Animal Study Suggests
4. Maryland In Home Dog Training Service has a Mission to Keep "Dogs with Behavior Problems" Out of the Animal Shelters
5. Females May Be Naturally More Prone to Stress: Animal Study
6. United Soybean Board New Site Features Farmers', Ranchers' Animal Care
7. Better animal-free test for chemicals that can cause contact dermatitis
8. Independent Study Reveals Family Bonds made Stronger on Vacations where Animals are Involved
9. McGill-UBC project creates mouse grimace scale to help identify pain in humans and animals
10. FDA Updates Import Alert 71-04 for Salmonella Contaminated Animal Feeds: Many Non-U.S. Firms Affected According to FDAImports.com, LLC
11. The effect of dietary supplements, acids and animal protein on gastrointestinal disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Animal Study Explores Potential Gene Therapy for Depression
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... City, Oklahoma (PRWEB) , ... June 25, 2016 ... ... helping both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic ... the Oklahoma City area —Johnson is one of the first doctors to perform ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... VEGAS , June 26, 2016 ... to value-based care operating models within the health care ... enable greater financial efficiency , Deloitte offers a ... the key business issues impacting efficient cost optimization: labor ... , These services facilitate better outcomes and better ...
(Date:6/24/2016)... , June 24, 2016 ... Markets has announced the addition of the " ... offering. This ... and provides an updated review, including its applications in ... the total market, which includes three main industries: pharmaceutical ...
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
Breaking Medicine Technology: