Navigation Links
Animal Experiments Shed Light on HIV's Ability to Hide
Date:7/21/2014

MONDAY, July 21, 2014 (HealthDay News) -- The "viral reservoir" in which HIV can lie dormant for years, avoiding detection and elimination, is established much earlier than previously thought, new animal research indicates.

This discovery poses new obstacles for those working to eradicate the AIDS-causing virus, said Harvard researchers working with the U.S. Military HIV Research Program. They said the presence of the viral reservoir remains the most significant challenge to finding a cure for a subtype of HIV, known as HIV-1.

"We found that the reservoir was established in tissues during the first few days of infection, before the virus was even detected in the blood," said the study's senior author, Dr. Dan Barouch, director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center in Boston.

For the study, published online July 20 in Nature, rhesus monkeys were infected intrarectally with simian immunodeficiency virus (SIV). SIV is believed to be the precursor of HIV in humans.

The researchers began antiretroviral therapy in groups of monkeys at three, seven, 10 and 14 days after they were infected with SIV.

Animals treated after three days showed no evidence of the virus in their blood and did not have an immune response to SIV. Despite six months of therapy, however, all of the animals had resurgence of the virus once treatment was stopped.

The investigators found that the earlier the treatment began, the longer it took for the virus to rebound, or become detectable in the blood. Still, the researchers concluded other strategies are needed to effectively cure HIV infection.

"The strikingly early seeding of the viral reservoir within the first few days of infection is sobering and presents new challenges to HIV-1 eradication efforts," the study authors wrote. The data suggest that extremely early initiation of [antiretroviral treatment], extended treatment and probably additional approaches that activate the viral reservoir will be required for HIV-1 eradication, they said.

The findings were reported in the wake of news that a Mississippi baby who was thought cured of HIV after receiving early antiretroviral therapy experienced a resurgence of the virus.

"The unfortunate news of the virus rebounding in this child further emphasizes the need to understand the early and refractory viral reservoir that is established very quickly following HIV infection in humans," added Barouch, a professor of medicine at Harvard Medical School in Boston, in a medical center news release.

Results of animal experiments aren't necessarily applicable to humans.

More information

The U.S. Department of Health and Human Services has more about HIV/AIDS.

SOURCE: Beth Israel Deaconess Medical Center, news release, July 20, 2014

--


'/>"/>
Copyright©2014 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers develop a new cell and animal model of inflammatory breast cancer
2. FDA Seeks to Limit Antibiotics in Animal Feed
3. Animals More Interesting to Kids Than Toys, Study Shows
4. Raucous Music May Tap Into Your Inner Animal
5. Recruiting for Good Launches Pet Philanthropy Program to Collaboratively Fundraise for Kitt Crusaders an Animal Rescue Organization
6. Woodbridge Animal Hospital Unleashes New Pet Care Website
7. Chicago Dog Bite Injury Lawyers Advise Dog Owners To Get Control of Their Animals, Or Be Prepared To Pay Up
8. New technique could reduce number of animals needed to test chemical safety
9. Potential treatment target identified in an animal model of pancreatic cancer
10. New animal model may lead to treatments for common liver disease
11. Lab-engineered muscle implants restore function in animals
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Animal Experiments Shed Light on HIV's Ability to Hide
(Date:4/29/2016)... ... April 29, 2016 , ... The Gluten-Free ... is pleased to announce the launch of the GFCP Scoop in ... more. The purpose of the GFCP Scoop site is to keep ...
(Date:4/29/2016)... ... ... Dr. Robert Mondavi, one of the dentists in Torrance , is ... field as more patients are discovering the many different ways they can change and ... available to them and which ones might work for their smiles. , “One ...
(Date:4/29/2016)... ... ... Reltok Nasal Products proudly announces that Boston Medical Products, Inc., a leading ... specialty, has added the KOTLER NASAL AIRWAY™ to its diverse product line. , A ... safety device secured by nasal surgeons onto the floor of the nasal passages, at ...
(Date:4/29/2016)... ... April 29, 2016 , ... Jvion, ... round of funding led by Eastside Partners, with participation from existing investor Martin ... customer base and accelerate its technology and product roadmap. , “Jvion ...
(Date:4/29/2016)... ... 2016 , ... Regenerative Medicine Solutions (RMS) scored 94.8124 out of ... them second place for Tampa’s Best Places to Work. They were ranked in the ... great accomplishment for our team,” says RMS Human Resources Manager Irene Miller. “We work ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... -- , Net Sales of $1.90 billion represent an ... year period, and an increase of 1.2% on an adjusted ... the first quarter were $0.52 reported, a decrease of 47.5% ... of 29.9% over the prior year period , The ... 2016 Zimmer Biomet Holdings, Inc. (NYSE and SIX: ...
(Date:4/28/2016)... April 28, 2016 Oramed Pharmaceuticals Inc. ... pharmaceutical company focused on the development of oral drug delivery ... upcoming PIONEERS 2016 conference, presented by Joseph Gunnar ... New York . Nadav Kidron , ... conference. Presentation Details:   PIONEERS ...
(Date:4/28/2016)... 2016  ValGenesis, Inc., the market leader ... today announced that a prominent world provider ... chronic kidney failure has selected ValGenesis Validation ... validation process. The global medical device manufacturer ... manage their validation processes electronically. Upon completion ...
Breaking Medicine Technology: