Navigation Links
Anesthetic approach stops pain without affecting motor function
Date:2/1/2010

BOSTON, Mass. - One of the holy grails of local anesthesia is the ability to achieve a long-lasting nerve block that eliminates pain sensation while not affecting motor function. Now, researchers at Children's Hospital Boston have discovered an anesthetic approach that seems to do just that. If it proves to work in humans as well as it did in rats, it could be useful in a variety of medical applications, providing, for example, a local anesthetic for childbirth that would block pain without interfering with the mother's ability to push, or for musculoskeletal disorders in which it is important to maintain mobility.

The discovery was reported in the online Early Edition of the Proceedings of the National Academy of Sciences during the week of February 1.

The researchers, led by Daniel Kohane, MD, PhD, of the Division of Critical Care Medicine at Children's, originally sought only to find an agent that would prolong the anesthetics' effects. They focused on surfactants, a subclass of so-called "chemical permeability enhancers" that enable drugs to spread more easily throughout a tissue.

In testing three kinds of surfactant along with the anesthetics QX-314 and QX-222 (both derivatives of lidocaine), they found that this approach did prolong the sensory block in rats' sciatic nerves, for up to 7 hours or more depending on the surfactant, but didn't prolong motor impairment; in some cases the motor block was absent or of very short duration. In the rats, this meant they were able to tolerate having their paws on a hot plate for long periods, yet still able to balance and bear weight on their legs.

"This was a surprise finding," says Kohane, who also directs the Laboratory for Biomaterials and Drug Delivery (LBDD) at Children's. "What we've discovered really is a new approach; the question now is to figure out the mechanism by which it works and look at the effects of other chemical permeability enhancers."

Kohane speculates that surfactant made the anesthetic better able to penetrate sensory nerves, which have little or none of the fatty coating known as myelin, whereas in motor neurons, which have abundant myelin, the active drug gets trapped in the myelin, never entering the nerve itself.

The lab's next steps will be to explore the effects of different permeability enhancers and examine their safety, since at high doses the drug combination could potentially be toxic to the nerves. The eventual plan is to test the approach in larger animals.

A parallel approach to achieving a pain-specific nerve block was proposed in 2007 by Clifford Woolf, MD, PhD, recently appointed director of the Children's Hospital Boston Program in Neurobiology. Woolf's team combined QXT-314 with capsaicin, which opens cellular gates that are only present in sensory neurons, and achieved pain-specific blocks in rats lasting 2 hours or more.


'/>"/>

Contact: Erin McColgan
erin.mccolgan@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Related medicine news :

1. Anesthetic Approach Stops Pain Without Affecting Motor Function
2. General anesthetics lead to learning disabilities in animal models
3. Finding of genetic region controlling cardiovascular sensitivity to anesthetic propofol
4. Mass. General team develops potentially safer general anesthetic
5. Cesarean section: Local anesthetic reduces need for painkillers post-op
6. As Fire Ants Continue to Proliferate, Hospital-Proven Burn Anesthetic Brings Instant Relief for Bites, Stings
7. Milestone Scientific Hosts Second Annual Symposium on Computer-Controlled Local Anesthetic Delivery (C-CLAD)
8. Researchers Create Long-Acting Local Anesthetic
9. Medical study shows epidurals and spinal anesthetics are safer than previously reported
10. MINRAD International, Inc. Announces Termination of RxElite Holdings Inc. as Anesthetics Distributor for the Human Market in United States
11. Common anesthetic induces Alzheimers-associated changes in mouse brains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... Orange City, FL (PRWEB) , ... February 11, ... ... has announced the commencement of a master charity program created to assist the ... every 60 days, working closely with nonprofit organizations and community leaders. Their hope ...
(Date:2/11/2016)... ... 11, 2016 , ... Dickinson Insurance & Financial Services continues their commitment to ... support of a local boy named Barrett, who has been fighting ALL leukemia for ... rally support for, all local families dealing with childhood cancer. Information on how to ...
(Date:2/11/2016)... City, Utah (PRWEB) , ... February 11, 2016 ... ... wireless microFET medical dynamometers and ergoFET force gauges used in physical therapy, occupational ... Rehab Strength Indicator sensor for resistance cord exercise and therapy, introduces its new ...
(Date:2/11/2016)... AZ (PRWEB) , ... February 11, 2016 , ... As ... with support of the Million Dollar Round Table Foundation (MDRTF), has gifted $10,000 to ... according to Colleen’s Dream Foundation President Billy Cundiff. , “We are honored to support ...
(Date:2/10/2016)... ... 10, 2016 , ... LaserShip, a regional parcel carrier that services the eastern ... Michigan last Friday in order to aid in the Flint water crisis. In 2014, ... facility located in Clio, only 15 miles away from Flint. , “We have deep ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 2016  Community pharmacists can help improve medication adherence ... through a custom-built medication synchronization program, Cardinal Health MedSync ... at Schieber Family Pharmacy in ... of patients enrolled in this medication synchronization program, which ... for the patient, and it,s a win for us ...
(Date:2/11/2016)... Calif. , Feb. 11, 2016 ... the use of the iFuse Implant System, a ... for certain disorders of the sacroiliac (SI) joint, ... the cost benefits of MIS SI joint fusion ... due to degenerative sacroiliitis or SI joint disruption.  ...
(Date:2/11/2016)... ENGLEWOOD, Colo. , Feb. 11, 2016  Ampio ... February 10, 2016, it entered into a Controlled Equity ... Co. ("Cantor Fitzgerald"). Michael Macaluso , Chairman ... we stated that we are not currently raising money ... through 2016 and into 2017 and still complete all ...
Breaking Medicine Technology: