Navigation Links
Anesthetic Approach Stops Pain Without Affecting Motor Function
Date:2/1/2010

o also directs the Laboratory for Biomaterials and Drug Delivery (LBDD) at Children's. "What we've discovered really is a new approach; the question now is to figure out the mechanism by which it works and look at the effects of other chemical permeability enhancers."

Kohane speculates that surfactant made the anesthetic better able to penetrate sensory nerves, which have little or none of the fatty coating known as myelin, whereas in motor neurons, which have abundant myelin, the active drug gets trapped in the myelin, never entering the nerve itself.

The lab's next steps will be to explore the effects of different permeability enhancers and examine their safety, since at high doses the drug combination could potentially be toxic to the nerves. The eventual plan is to test the approach in larger animals.

A parallel approach to achieving a pain-specific nerve block was proposed in 2007 by Clifford Woolf, MD, PhD, recently appointed director of the Children's Hospital Boston Program in Neurobiology. Woolf's team combined QXT-314 with capsaicin, which opens cellular gates that are only present in sensory neurons, and achieved pain-specific blocks in rats lasting 2 hours or more.

The new study was funded by the National Institutes of General Medical Sciences. Itay Sagie, a research associate at the LBDD, was the paper's first author. For licensing information, see: www.childrensinnovations.org/SearchDetails.aspx?id=1679.

Citation: Sagie I and Kohane D. Prolonged sensory-selective nerve blockade. PNAS online early edition, week of February 1, 2010.


'/>"/>
SOURCE Children's Hospital Boston
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. General anesthetics lead to learning disabilities in animal models
2. Finding of genetic region controlling cardiovascular sensitivity to anesthetic propofol
3. Mass. General team develops potentially safer general anesthetic
4. Cesarean section: Local anesthetic reduces need for painkillers post-op
5. As Fire Ants Continue to Proliferate, Hospital-Proven Burn Anesthetic Brings Instant Relief for Bites, Stings
6. Milestone Scientific Hosts Second Annual Symposium on Computer-Controlled Local Anesthetic Delivery (C-CLAD)
7. Researchers Create Long-Acting Local Anesthetic
8. Medical study shows epidurals and spinal anesthetics are safer than previously reported
9. MINRAD International, Inc. Announces Termination of RxElite Holdings Inc. as Anesthetics Distributor for the Human Market in United States
10. Common anesthetic induces Alzheimers-associated changes in mouse brains
11. Over-the-counter anesthetic gel puts the squeeze on mammogram pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... The short film “Color of Honor” by young director/producer ... true 9/11 hero, Welles Remy Crowther. It has been chosen ... of Nuremberg International Short Film Festival and the 8th International ... and director Luciana Lagana plays the mother of the ... Gregory Graham - Graham plays a heroic policeman ...
(Date:12/25/2014)... Helen Harris’ RP (Retinitis Pigmentosa) International ... after an 8 year battle with breast cancer. ... in her home in Woodland Hills California after an ... , As the founder and volunteer President ... and championed many of today's greatest breakthroughs in restoring ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. 24, ... illnesses can receive effective, less expensive care from a clinic ... a team of dedicated health care professionals, a new study ... and need either hospitalization or a trip to the emergency ... clinic at the University of Texas in Houston versus usual ...
(Date:12/25/2014)... early stage breast cancer patients who undergo chemotherapy and/or ... eventually develop leukemia as a result of their treatment, ... a review of more than 20,000 breast cancer cases ... the risk for developing treatment-related leukemia, though low, is ... frequency of bone marrow cancers such as leukemia is ...
(Date:12/25/2014)... 2014 Thousands of transvaginal mesh lawsuits ... a number of multidistrict litigations currently underway in U.S. ... LLP reports. According to an Order issued on December ... Joint Status Conference in all of the proceedings on ... directed to submit a proposed agenda to the Court ...
Breaking Medicine News(10 mins):Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4
... 26 launch of the Personal Trainer(TM): Walking game, ... into an enriching, entertaining experience. , , See ... After counting and recording users, steps throughout the day, ... activities to reveal life rhythm patterns. For instance, the readout ...
... Phoenix Suns forward Amar,e Stoudemire shared his personal ... The Vision Council,s Vision Summit in Washington, DC. ... repair a detached retina following an on-court incident. ... season, which led Stoudemire to declare he will ...
... (Nasdaq: VNDA ) announced today that it will ... 27, 2009, in Rockville, Maryland. The record date for ... stockholders of record at the close of business on June ... thereof. Vanda anticipates mailing its proxy statement in July ...
... the IHSS ProgramSACRAMENTO, Calif., May 29 Gov. ... Home Supportive Services (IHSS) program that would all ... for more than 420,000 low-income elderly, blind and ... 380,000 individuals--nearly 90 percent of all IHSS consumers--would ...
... Pharmaceuticals (Nasdaq: ENDP ) announced today that the ... restricted stock units and an option to purchase 80,000 shares ... Endo,s executive vice president and chief financial officer. These ... incentive plan but are subject to the terms and conditions ...
... Alliance (LCA) said that the American Cancer Society,s ... week was based on "selective culling of statistics ... made very little progress on the most lethal ... every two cancer deaths, or in metastatic cancer ...
Cached Medicine News:Health News:VIDEO from Medialink and Nintendo: Nintendo Steps Up the Pace With Personal Trainer: Walking 2Health News:NBA All-Star Amar'e Stoudemire Discusses Season-Ending Eye Injury and the Importance of Protective Eyewear 2Health News:Schwarzenegger Wants To Eliminate Home Care For 400,000 Elderly, Blind and Disabled Californians 2Health News:Endo Announces Compensation for New CFO Alan Levin 2Health News:Lung Cancer Alliance Calls American Cancer Society's Claim of Progress Selective 2
(Date:12/24/2014)... 23, 2014  The American Diabetes Association is ... for people with diabetes and that all people ... of statins, in keeping with recent changes to ... American College of Cardiology (ACC) and American Heart ... most recent changes to the Association,s annual revised ...
(Date:12/24/2014)... 2014  Medical Science Liaisons play a large role ... the medical device industry and key stakeholders, the role ... years as the device industry relies on them to ... by benchmarking firm, Best Practices, LLC, one area where ... is by harnessing new technology to enable education. Online ...
(Date:12/22/2014)... DUBLIN , Dec. 22, 2014 Research and ... addition of the "US Self-monitoring Blood Glucose Market" ... http://photos.prnewswire.com/prnh/20130307/600769 This market insight focuses ... in the United States . Reimbursement ... studied. Thorough product analyses for more than 73 SMBG ...
Breaking Medicine Technology:New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4Role of Medical Science Liaisons Evolving in Medical Device Sector 2US Self-monitoring Blood Glucose Market 2
... 2011 Virtual Radiologic (vRad), a technology-enabled ... Award for Sales & Customer Service. vRad® Results (SM) ... the Internet, that provides secure access to images and ... mobile digital devices and the Internet. vRad received the ...
... 31, 2011 NewCardio, Inc., (OTC Bulletin Board: ... today that the Company has been invited to present ... at an upcoming conference entitled "Cardiovascular Safety in Drug ... Drug Administration (FDA), the Cardiac Safety Research Consortium (CSRC) ...
Cached Medicine Technology:Virtual Radiologic Wins Stevie® Award for Improving Patient Care through Mobile Technology 2NewCardio Invited to Present Latest QTinno Performance Improvements at FDA-Sponsored Conference on Cardiovascular Safety in Drug Development 2NewCardio Invited to Present Latest QTinno Performance Improvements at FDA-Sponsored Conference on Cardiovascular Safety in Drug Development 3NewCardio Invited to Present Latest QTinno Performance Improvements at FDA-Sponsored Conference on Cardiovascular Safety in Drug Development 4NewCardio Invited to Present Latest QTinno Performance Improvements at FDA-Sponsored Conference on Cardiovascular Safety in Drug Development 5NewCardio Invited to Present Latest QTinno Performance Improvements at FDA-Sponsored Conference on Cardiovascular Safety in Drug Development 6
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: