Navigation Links
Anemia tougher to tackle in black children with kidney disease
Date:4/26/2010

Black children with chronic kidney disease have more severe anemia than white children even when they receive the same treatment, according to a multicenter study led by Johns Hopkins Children's Center to be published in the May issue of the American Journal of Kidney Disease.

The findings suggest that inherent biological differences, rather than access to care and treatment, may be at play, raising the question whether current guidelines for anemia treatment should be tailored to reflect race, investigators say.

Anemia, marked by abnormally low levels of red blood cells, is a key indicator of disease status. It is diagnosed by measuring levels of the protein hemoglobin, which carries oxygen in and out of red blood cells. Hemoglobin levels below 11 grams per deciliter of blood generally indicate anemia, but the number is adjusted for a child's age and gender.

In the new study, black children with kidney disease had lower hemoglobin than white children, 0.6 grams per deciliter on average, and a greater proportion of black children were anemic when compared with white children. The difference persisted even after researchers eliminated certain factors that affect hemoglobin levels, such as severity of kidney disease and whether the children received treatment with hemoglobin-boosting medications for their anemia.

"As we move from one-size-fits-all medicine toward individualized medicine, we should study further racial disparities and, perhaps, adjust hemoglobin targets to reflect what appear to be genetic variations," said lead investigator Meredith Atkinson, M.D., M.H.S., a pediatric nephrologist at Johns Hopkins Children's.

Racial differences in hemoglobin levels are nothing new in adults with chronic kidney disease, researchers say, nor are slight variations in hemoglobin between healthy white and black children.

The tricky part, researchers say, is differentiating between "true" anemia and normal racial variations in hemoglobin levels.

The Hopkins-led study involved 429 children ages 1 to 16 with chronic kidney disease enrolled in 44 study sites across the United States. More than 40 percent of black children had hemoglobin levels below the fifth percentile for their age and gender deemed a critical cutoff point compared to 29 percent of white children. Also, fewer African-American than white children reached higher hemoglobin levels with treatment. The differences persisted even after researchers controlled for factors affecting hemoglobin levels, such as an iron-rich diet and body-mass index.

Moreover, researchers found that as the disease progressed and the anemia got worse across the board for all children, the hemoglobin gap between white and black children widened. This finding suggests that as the disease progresses, pediatric nephrologists should monitor even more vigilantly hemoglobin levels in their African-American patients.

"What we are observing could very well mean that black children's hemoglobin levels start to plummet once they reach a certain point in their disease," Atkinson said.

Untreated, chronic anemia can speed disease progression and, over time, can lead to a dangerous thickening of the heart muscle called left-ventricular hypertrophy, among other complications.

Chronic kidney disease affects 26 million people in the United States.


'/>"/>

Contact: Ekaterina Pesheva
epeshev1@jhmi.edu
410-516-4996
Johns Hopkins Medical Institutions
Source:Eurekalert

Related medicine news :

1. For Some on Dialysis, Anemia Drugs Pose Risks
2. FDA Tightens Controls on Anemia Drugs
3. Anemia drug not helpful for kidney disease patients
4. Recent Book Moves Beyond Defensive Medicine, Tackles Entitlement Reform
5. Breast Cancer Survivor Tackles the Missing Link: Inspiring Event Offers Women Real Life Advice to Thrive After Medical Treatment Ends
6. Iowan Tackles Everest and More in Unprecedented Adventure
7. Medical schools partner to tackle barriers to minority participation in cancer clinical trials
8. Kay's Naturals Answers Obama's Call to Tackle Childhood Obesity
9. Get up, get out and go: NC State research tackles childhood obesity
10. Founder and President of BOMF, Anne Mahlum, Speaks on How Running Helps to Tackle Homelessness, at National Press Club
11. New developments in nanotechnology tackle the 2 biggest problems associated with chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
(Date:6/24/2016)... TX (PRWEB) , ... June 24, 2016 , ... People ... part in Genome magazine’s Code Talker Award, an essay contest in which patients and ... an award to be presented at the 2016 National Society of Genetic Counselors (NSGC) ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the Frederick area economy by obtaining investment capital for emerging technology companies. ... years that have already resulted in more than a million dollars of capital ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... supporting the upcoming 2016 Miss Arizona pageant as its official Medspa Sponsor. Dr. ... Tempe, Mesa, and Chandler, Arizona. , Dr. Olson says the decision to ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
(Date:6/23/2016)... , June 23, 2016 , ... Thursday, July 7, 2016 , , , , LOCATION: , ... , , , , EXPERT PANELISTS:  , , , Frost ... Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh ... The global pharmaceutical industry is witnessing an exceptional era. Several ...
Breaking Medicine Technology: