Anemia Drugs May Speed Tumor Growth in Some Cance... (. . . these agents may have some stimula...)

Anemia Drugs May Speed Tumor Growth in Some Cancer Patients

Date:6/1/2008

. . . these agents may have some stimulatory effects on tumor cells, faster progression in some cases, and more death in others."

Until recently, Blau added, these drugs represented the biggest U.S. federal expenditures for oncology patients.

The results of the current study were based on analyses of tumor samples from 101 patients diagnosed with head and neck cancer who had participated in a previous phase III trial of erythropoietin.

Scientists measured levels of erythropoietin receptor (EpoR) messenger RNA (mRNA).

High levels of EpoR mRNA in patients who had undergone radiation but not surgery tended to signal a worse prognosis. There was a similar effect with Janus Kinase 2 (Jak2), the main intermediary of EpoR signaling, Blau added.

"These are preliminary findings, but they're very exciting," Gralow said. "If they hold up, they may mean that we may be able to use ESAs in targeted ways."

"These findings must be considered preliminary until confirmed," added Blau. "We believe that the definitive answer to this question lies locked in the filing cabinets of pathologists' offices that contain tumors of patients who participated in already completed phase III studies." That, of course, would be much easier than initiating entirely new studies.

A second study found the multiple drugs elderly cancer patients may already be taking could interact significantly with chemotherapy.

In particular, patients taking drugs that interfered with protein binding such as Norvasc for high blood pressure, Prilosec for heartburn, and the pain reliever Celebrex were more likely to experience hematologic side effects such as low white blood cell counts.

Patients taking drugs that act on a group of enzymes known as cytochrome p450 were more likely to experience effects such as fatigue or diarrhea. Examples of these drugs include the heart medications such as Pacerone and Cordarone.

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Anemia Drugs May Speed Tumor Growth in Some Cance...(. . . these agents may have some stimula...),Health