Navigation Links
Anemia Drugs Hold Dangers for Kidney Patients
Date:5/5/2010

Study finds increased risks for potential deadly complications

WEDNESDAY, May 5 (HealthDay News) -- The powerful drugs used to fight anemia caused by kidney failure increase the risk for cardiovascular problems such as heart attack, a major study has found.

A meta-analysis of 27 trials, which included more than 10,000 people who were given the drugs, known as erythropoiesis-stimulating agents (ESAs), found that those who took the drugs at the highest dosages had a 51 percent increased risk for stroke and a 33 percent increased risk for thrombosis, or blockage of an artery. The study, by an international group of experts, was published online May 3 in Annals of Internal Medicine.

The increased risk for death (9 percent) and serious cardiovascular events such as heart attacks (15 percent) did not reach statistical significance, the analysis found.

The U.S. Food and Drug Administration has acted to control the use of ESAs marketed as Epogen, Procrit and Aranesp, which stimulate production of red blood cells to treat the anemia caused by kidney failure and cancer chemotherapy. The agency has added a "black box" warning of dangers to ESA labeling.

The new study adds emphasis to such moves, said Dr. Ajay K. Singh, an associate professor of medicine at Harvard Medical School and a nephrologist at Brigham and Women's Hospital in Boston.

"This meta-analysis shows increased risk with no benefit," Singh said. "The supposed benefit is that ESAs improve quality of life and make people feel better. This study suggests that these drugs, used at considerable cost, don't show any benefit in terms of those endpoints."

ESAs cost Medicare $2 billion a year, Singh said, making them the most expensive drugs in terms of cost that the government has paid for.

Yet ESAs do have a role in treating some people with chronic kidney disease, despite their dangers, Singh said.

The new FDA
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Anemia Harder to Treat in Black Children With Kidney Disease
2. Anemia tougher to tackle in black children with kidney disease
3. For Some on Dialysis, Anemia Drugs Pose Risks
4. FDA Tightens Controls on Anemia Drugs
5. Anemia drug not helpful for kidney disease patients
6. As FDA Eyes Prostate Cancer Drugs, Experts Urge Caution
7. Taking Flu Drugs While Pregnant Appears to Be Safe: Study
8. OTC Drugs May Work Differently in Obese Kids
9. Study finds that drugs used for treatment of influenza in pregnancy appear to be safe
10. BATTLE links potential biomarkers to drugs for lung cancer
11. Matching Tumor Types to Drugs Boosts Lung Cancer Outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Oceanside,CA (PRWEB) January 22, 2015 For over 20 ... the Oceanside and Vista area has treated just about ... other personal injury circumstances. And for those same twenty-plus years, ... victims of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... 22, 2015 A study recently ... flagship journal Medicine & Science in Sports & ... may help reduce gastrointestinal (GI) problems associated with ... Participants in the double-blind, placebo-controlled study took 10 ...
(Date:1/22/2015)... City, Florida (PRWEB) January 22, 2015 IsoComforter, ... cold therapy machine with patented IsoTube design to treat specific ... has introduced the most progressive and easy to use patented ... treat post-operative and sports related orthopedic and muscle injuries. ...
(Date:1/22/2015)... Mass. (PRWEB) January 22, 2015 EBSCO ... (AMA) are expanding their relationship in an effort to ... around the world. While EBSCO has long made AMA journals ... a sales agent for The JAMA Network. , ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Compare-autoinsurance.org has released a ... insured by an auto insurance policy . , Some ... policy. Clients should check the newly released blog post to see ... cars and dangerously damaged vehicles are some of the cars that ...
Breaking Medicine News(10 mins):Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2
... By Steven Reinberg HealthDay Reporter , TUESDAY, ... advanced non-small cell lung cancer appear to get no ... chemotherapy, researchers from the Dana-Farber Cancer Institute report. ... improve survival, but not in patients aged 65 and ...
... ANN ARBOR, Mich. Kidney cancer patients who had ... had their entire kidney removed, according to a new study ... After an average of five years, 25 percent of ... the tumor and a small margin of healthy tissue is ...
... Regenstrief Institute investigator Christopher Callahan, M.D., Cornelius and ... School of Medicine and director of the IU Center ... for Career Achievement and Contribution to Clinical and Translational ... Washington, D.C., April 18 to 20. Dr. Callahan, ...
... in young children and can lead to difficulties in ... mothers, depression has consistently been identified as one. Now ... levels of symptoms of depression might act in ways ... insights about maternal depression,s effects on nighttime parenting, and ...
... HealthDay Reporter , MONDAY, April 16 (HealthDay News) -- ... benefit on multiple sclerosis (MS), according a study by ... people worldwide. Some prior research has indicated that omega-3 ... benefit those with the disease, according to background information ...
... Gardner HealthDay Reporter , MONDAY, April 16 ... have dropped 30 percent since 2000 but still remain ... new statistics released by the U.S. Centers for Disease ... children died from unintentional injuries in the U.S. in ...
Cached Medicine News:Health News:Avastin No Benefit to Older Lung Cancer Patients: Study 2Health News:Avastin No Benefit to Older Lung Cancer Patients: Study 3Health News:Kidney cancer patients do better when whole kidney is not removed, U-M study shows 2Health News:Callahan honored for improving older adults' health in their doctors' offices 2Health News:Depressed moms' behavior may play role in infants' sleep problems 2Health News:Fish Oil Supplements Won't Help in Multiple Sclerosis: Study 2Health News:Death From Accidental Injuries Among Kids Drops 30%: CDC 2Health News:Death From Accidental Injuries Among Kids Drops 30%: CDC 3
(Date:1/23/2015)... and BOSTON , January 23, 2015 ... discovery and development company, is delighted to announce that the ... awarded to Miles Congreve (Vice President of Chemistry), ... Malcolm Weir (Chief Executive Officer and co-founder) for ...
(Date:1/22/2015)... Colo. , Jan. 22, 2015  BiOptix is pleased ... as Vice President of Chemistry and Biochemistry. Scott joins ... Pharmaceuticals, AstraZeneca Pharmaceuticals, and Amgen throughout the course of ... development. "Scott is a nationally recognized thought ...
(Date:1/22/2015)... WOODBRIDGE, ON , Jan. 22, 2015 /PRNewswire/ - Pivotal Therapeutics ... company with a focus on Omega-3 therapies for cardiovascular disease ... summary of the Company,s accomplishments in 2014 and its outlook ... Dear Fellow Shareholders, We would like ...
Breaking Medicine Technology:Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7
... in Carotid Atherosclerosis, LEXINGTON, Mass., Oct. 24 ... its pivotal clinical trial (PROVIDENCE-1),studying the effect of ... peripheral arterial disease (PAD) will be,presented on November ... late breaker,Scientific Session at the American Heart Association,s ...
... Today the National Legal and Policy,Center (NLPC) asked ... for,International Development (USAID) to investigate the possibility that ... groups operating,needle exchange programs for drug users in ... activist George,Soros are recipients of these legally questionable ...
Cached Medicine Technology:ActivBiotics to Present Results of Pivotal Study in the Treatment of Peripheral Arterial Disease at AHA Meeting 2ActivBiotics to Present Results of Pivotal Study in the Treatment of Peripheral Arterial Disease at AHA Meeting 3Ethics Group Asks USAID Inspector General to Investigate Legality of Grants to Soros Groups 2
Standard general retractor system. Fully-adjustable to maintain a low profile in any approach and any patient. Blades can be stacked on top of each other in the operative site....
These retractors, made of rugged Noryl® resin, are pre-sterilized and packaged singly in double peel-pouches for easy delivery to the sterile surgical field....
... abdominal surgery, the Alexis Wound Retractor ... wound from contamination. For open surgery, ... while minimizing the incision size. For ... instrumental in offering retraction and protection ...
HemoNIR™ is a portable device that measures the ability of apersons blood to carry oxygen by monitoring functional vs. non functional hemoglobin....
Medicine Products: