Navigation Links
Andrew J. Dannenberg, M.D., honored with AACR-Prevent Cancer Foundation Award
Date:10/19/2011

PHILADELPHIA The AACR will present the 2011 AACR-Prevent Cancer Foundation Award for Excellence in Cancer Prevention Research to Andrew J. Dannenberg, M.D., at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, held Oct. 22-25, 2011. Dannenberg is director of the Weill Cornell Cancer Center and director of cancer prevention at New York-Presbyterian/Weill Cornell Medical Center. He is also the Henry R. Erle, M.D.-Roberts Family Professor of Medicine at Weill Cornell Medical College.

Dannenberg's work has provided the basis for the transformative discovery linking obesity, inflammation and breast cancer. He is recognized for his work on the inflammation-cancer connection with an emphasis on prostaglandin biology. Dannenberg's research has been of major importance in explaining why levels of procarcinogenic prostaglandins are increased in inflamed tissues and tumors. He has also made major contributions to our understanding of why nonsteroidal anti-inflammatory drugs show chemopreventive activity.

The AACR-Prevent Cancer Foundation Award for Excellence in Cancer Prevention Research is given annually for seminal laboratory, translational, clinical, epidemiological or behavioral science contributions to the field of cancer prevention.

Dannenberg's significant contributions include demonstrating that COX-2 was overexpressed in a variety of premalignant lesions and cancers; elucidating the mechanisms by which oncogenes, tumor suppressor genes, carcinogens and tumor promoters regulate COX-2 gene expression; utilizing both pharmacological and genetic strategies to establish the importance of targeting prostaglandin synthesis as a bona fide prevention strategy; defining the signal transduction pathways by which dietary and synthetic chemopreventive agents suppress COX-2 transcription and prostaglandin synthesis; and determining the signaling mechanism by which COX-derived prostaglandin E2 induced aromatase, the rate-limiting enzyme responsible for estrogen synthesis. This latter work led to an observational study in which the use of aspirin was associated with a reduced risk for hormone receptor-positive breast cancer.

In his most recent work that provides new insights into the link between obesity, inflammation and breast cancer, Dannenberg conducted a preclinical study in which he used experimental models to demonstrate the presence of the obesityinflammationaromatase axis in the mammary gland. As a result, COX-2-derived PGE2 appeared to play an important role in inducing aromatase in the mammary glands of obese mice. Subsequently, he successfully translated these preclinical findings.

Dannenberg will present his lecture, "Obesity and Breast Inflammation: Implications for Cancer Prevention," on Sunday, Oct. 23, 2011, at 5:15 p.m.


'/>"/>

Contact: Michele Sharp
Michele.Sharp@aacr.org
267-446-7156
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Cedars-Sinai Medical Center Names Beverly Hills Plastic Surgeon Dr. Andrew Cohen as Chief of the Center for Plastic and Reconstructive Surgery
2. Counseling Suicidal Clients by Andrew Reeves
3. UCSF neurologist William Seeley, M.D., named MacArthur Fellow
4. Dale Browne, M.D., ear, nose, and throat specialist, receives award from National Medical Society
5. Ching-Hon Pui, M.D., honored by the American Society of Hematology for work in childhood cancer
6. BUS Jeffrey H. Samet, M.D., selected as a 2011 NIDA International Program Awards of Excellence winner
7. Mayo Clinic: Raoul Tibes, M.D., Ph.D., to receive Career Development Award
8. BIDMCs Peter Weller, M.D., receives NIH MERIT Award
9. BIDMC neurologist Bernard Chang, M.D., receives award for epilepsy research
10. Alfred B. Knight, M.D., Scott & White Healthcare, presents at 8th Annual World Health Care Congress
11. Ching-Hon Pui, M.D., recognized with American Association for Cancer Research award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are ... with endometriosis. These women need a treatment plan to not only alleviate symptoms ... can help for preservation of fertility and ultimately achieving a pregnancy. The specialists ...
(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda ... orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including ... accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 According to a new ... Pen Needles, Safety Pen Needles), Needle Length (4mm, 5mm, ... Mode of Purchase (Retail, Non-Retail) - Trends & Global ... the market for the forecast period of 2016 to ... Billion by 2021 from USD 1.65 Billion in 2016, ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data derived ... Assessment of major trends with potential impact on the market ... of market segmentation which comprises of sub markets, regional and ...
Breaking Medicine Technology: