Navigation Links
Ancient mechanism for coping with stresses also gives cancer a boost
Date:9/20/2007

ls, but not the normal cells, were strongly affected by HSF1's inhibition. Those findings led them to conclude that "HSF1 function helps to maintain the growth and survival of human cancer cells with diverse underlying malignant defects."

The results may have therapeutic implications, the researcher said, as an expanding array of small, drug-like compounds with potent effects on HSF1 are now becoming available. Indeed, drugs that ramp up the heat-shock response are being explored for treating ischemic injury and neurodegenerative diseases, including Huntington's and Parkinson's diseases.

The new findings raise concern that such therapies might increase the risk of cancer, Lindquist said. On the other hand, treatments designed to block HSF1 might "provide a multifaceted and broadly effective cancer chemopreventative as well as chemotherapeutic strategy."

The results also point to the delicate balance between aging, longevity, and cancer risk, she added.

"Strikingly, our data now make clear that HSF1 plays opposite roles in the complex diseases that plague aging populations," she said. "It powerfully potentiates the development of cancers. But it has also been implicated in protection against ischemia/re-perfusion injury, neurodegenerative disorders and in other broad-ranging physiological processes affecting lifespan. We are poised on the balance between aging and degeneration [on one side] and the active, youthful cell growth, [which can lead to cancer], on the other. If we pay more attention and learn how to manipulate these systems properly, we could have a huge impact on human disease."


'/>"/>

Contact: Nancy Wampler
nwampler@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Respecting Dwarfs- A Lesson To Be Learnt From Ancient Egyptians
2. Scientists found ancient Human Germ Killer
3. A Plant Used By Ancient Britons Found To Have Properties To Fight Cancer
4. Mining of Ancient Herbal Text Leads to Potential New Anti-Bacterial Drug
5. Ancient Herbal Text Paves the Way to Novel Anti-bacterial Drug
6. Mining of Ancient Herbal Text Leads to Potential New Anti-Bacterial Drug
7. Ancient Genes Used to Produce Salt-Tolerant Wheat
8. Ancient Worm Disease Could Be Eradicated Within Two Years, UN Agency Reports
9. Ancient Indian Herb May Prove Cure For Recurrent UTI
10. Ancient Healing Technique Gains New Popularity in Iraq
11. Ancient Ancestors Might Have Had a Clue to HIV
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... (PRWEB) April 18, 2015 Carinsurancehints.com has released ... insurance plans that offer financial protection against fire damage. ... will pay benefits in case their vehicle is set intentionally ... vandalism caused by rioting or by other things. , ... quotes on a single website http://www.carinsurancehints.com/ , in ...
(Date:4/18/2015)... PITTSBURGH, PA (PRWEB) April 18, 2015 ... so I decided to create a healthful juice ... an inventor from Rosedale, Md. "It increases my ... overall healthy body." , He developed Tapp's Juice ... The juice helps to prevent physical and mental ...
(Date:4/18/2015)... April 18, 2015 Insuranceautoquote.info has released ... online auto insurance quotes . , Clients can ... single website. The online environment provides important advantages for ... , Drivers who do not have coverage for ... during any season, day or hour. Many agencies offer ...
(Date:4/18/2015)... has released a new blog post explaining how to ... , Drivers can find accurate information about various auto ... website can help drivers compare the newest and best ... whole process is designed to be convenient, free and ... quotes is advantageous because it allows clients to find ...
(Date:4/18/2015)... 2015 Thousand of DePuy Pinnacle hip ... individuals who were allegedly harmed by a metal-on-metal version ... in the U.S. District Court, Northern District of Texas. ... has amended an earlier Case Management Order to allow ... the new amendment permits the claims of up to ...
Breaking Medicine News(10 mins):Health News:Online Auto Insurance Quotes For Plans That Cover Fire Damages! 2Health News:Clients Can Review Car Insurance Quotes Online To Find Low Cost Offers! 2Health News:Auto Insurance Quotes Can Provide Accurate Results! 2Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 2Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 3
... www.mobilemassageteam.com ), a leading provider of on-site seated ... affairs, today announced that the company will be a sponsor ... ( http://www.globalfit.com/summit/ ) held on Thursday, ... City Philadelphia. Team members will be set up on ...
... Fight Against Tobacco Recognized Nationally -WASHINGTON, May 6 ... has been named the National Youth Advocate of the Year ... the fight against tobacco. Emily is being honored at a ... regional winners and a group winner. (Logo: ...
... released today by Ernst Berndt and Mark Trusheim of ... that eliminating FDA,s preemption protection would decrease patients, access ... reduce medical device industry employment. The paper, ... Devices on Patients, Innovation and Jobs," comes as ...
... Symmetry Medical Inc. (NYSE: SMA ), a leading ... and other medical markets, announced today that Brian S. Moore, ... Vice President and Chief Financial Officer, are scheduled to present ... Conference at the Palace Hotel in New York City on ...
... Performance athletes need to know their blood lactate level. ... their blood as a result of physical exertion and ... athletes therefore regularly have to attend performance diagnosis sessions. ... of exertion, a doctor takes blood samples from an ...
... May 6 /PRNewswire-Asia-FirstCall/ -- BMP Sunstone,Corporation (Nasdaq: BJGP ) (,BMP ... , -- Oppenheimer 3rd Annual China Dragon Call Conference, ... Madison Avenue in New York City. Management is currently, ... at 8:30, am ET on Tuesday, ...
Cached Medicine News:Health News:Campaign for Tobacco-Free Kids Honors Emily Kile, Greenfield, IN, as National Youth Advocate of the Year 2Health News:Removing Medical Device Preemption Impacts Jobs, Health Care Costs, Patient Access 2Health News:Symmetry Medical to Present at Bank of America and Merrill Lynch 2009 Healthcare Conference 2Health News:Lactate test made easy 2
(Date:4/17/2015)... 17, 2015  Regulatory leaders in the pharmaceutical industry ... draft called "21 st Century Cures." ... taken up by Congress soon and if enacted into ... products are developed and marketed in the ... have begun to consider how the proposed changes could ...
(Date:4/17/2015)... 2015 LifeScienceIndustryResearch.com announces having ... on Global and China Lysine Industry to its ... and the deep research report in this field. ... information including definition, classification specifications, application, industry chain ... Europe , Japan ...
(Date:4/17/2015)... Research and Markets ( http://www.researchandmarkets.com/research/6tdwh8/medical_device ... "Medical Device Outsourcing - Global Strategic Business Report" ... report analyzes the worldwide markets for Medical Device ... Categories: Class I, Class II, and Class III. ... Include - Radiology, Orthopedic, Neurology, Cardiology, and Others. ...
Breaking Medicine Technology:21st Century Cures: A Regulatory Game-Changer for the Pharmaceutical Industry 2Lysine Market International (US, Europe, Japan) Research Analysis 2Lysine Market International (US, Europe, Japan) Research Analysis 3Lysine Market International (US, Europe, Japan) Research Analysis 4Lysine Market International (US, Europe, Japan) Research Analysis 5Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 2Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 3
... ELISA products make us a leader in ... faster integration into the busy laboratory, our ... and run-to-run consistency. Our Infectious Disease ELISA ... wide range of serological assays including ToRCH, ...
... breadth of infectious disease ELISA products make ... standard assay protocols for faster integration into ... products provide increased reliability and run-to-run consistency. ... detection assays for a wide range of ...
... Our breadth of infectious disease ELISA products ... With standard assay protocols for faster integration ... ELISA products provide increased reliability and run-to-run ... antibody detection assays for a wide range ...
... a complete line of enteric ... monoclonal and monoclonal/polyclonal antibody-based ELISA ... enteric pathogens in fecal specimens. ... Clostridium difficile, Entamoeba histolytica, Giardia, ...
Medicine Products: