Navigation Links
Ancient Chinese medicine put through its paces for pancreatic cancer
Date:3/2/2014

SAN ANTONIO (March 3, 2014) The bark of the Amur cork tree (Phellodendron amurense) has traveled a centuries-long road with the healing arts. Now it is being put through its paces by science in the fight against pancreatic cancer, with the potential to make inroads against several more.

UT Health Science Center researcher A. Pratap Kumar was already exploring the cork tree extract's promise in treating prostate cancer when his team found that deadly pancreatic cancers share some similar development pathways with prostate tumors.

In a paper published today in the journal Clinical Cancer Research, the researchers show that the extract blocks those pathways and inhibits the scarring that thwarts anti-cancer drugs. Dr. Jingjing Gong, currently pursuing post-doctoral studies at Yale University, conducted the study as a graduate student in Dr Kumar's laboratory in the Department of Pharmacology.

"Fibrosis is a process of uncontrolled scarring around the tumor gland," said Dr. Kumar, a professor of urology in the School of Medicine at the Health Science Center and the study's principal investigator. "Once you have fibrotic tissue, the drugs cannot get into the cancer."

Liver and kidney tumors also develop fibrosis and the resulting resistance to drugs, he said, and there are no drugs currently targeting that pathway in those cancers.

The two pathways, or proteins, that contribute to fibrosis in those tumors also encourage Cox-2, an enzyme that causes inflammation, and the cork tree extract appears to suppress that as well, Dr. Kumar said. The complex interrelationship of these substances is "the million-dollar question," he said, and solving that question is one of the next steps in his research.

The potential of natural substances to treat and cure disease has great appeal, but the advantage of cork tree extract, available as a dietary supplement in capsule form, is that it already has been established as safe for use in patients. In a promising prostate cancer clinical study of 24 patients that Dr. Kumar helped spearhead, all the patients tolerated the treatment well, he said. Now researchers are analyzing the results, he said, and with more funding they plan to expand the study to a much larger group of patients.

The dietary supplement is marketed as Nexrutine by Next Pharmaceuticals of Salinas, Calif., which provided a supply of the compound for the studies.


'/>"/>

Contact: Elizabeth Allen
allenea@uthscsa.edu
210-450-2020
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Related medicine news :

1. New twist on ancient math problem could improve medicine, microelectronics
2. Ancient Genome Appears to Have Links to Modern Humans
3. Clues to Ancient Dentistry Found in Human Tooth
4. Spirit Detox Announces Addition of Ancient Clay Natural Soap Line to Beauty Products
5. Online Homeopathic Retailer Kanwa Minerals Announces New Native Remedies; Ancient Clay Soaps, Native Clay Face Mask, Eco Gifts for Women
6. Ancient Pills Found in Shipwreck Offer Rare Insight Into Early Medicine
7. A Piece of Family Tradition Found In Every Bar of Soap - An Ancient Family Recipe from Mexico Inspires the Launch of Montes Botanicals Bath & Body
8. Ancient Native Remedy: Healing with Clay prescribed as Powerful Medicine: Zion Health's Clay Bath Detox Minerals now Available at Weaver’s Way Co-op in Philadelphia
9. Ayurvedic Massage training: Healing through Ancient Therapeutic Massage (Abhyanga)
10. Zion Health Announces Native Remedy; Ancient Clay Organic Soaps with High-grade Bentonite Clay; Now Available at Down to Earth Health food store in Hawaii
11. Zion Health Announces Vegan-Friendly Line of Ancient Clay Organic Soaps and Healing Native Remedies; Now Available at Veggie Monster in Woodside, NY.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... ... ... Maury Regional Health has announced a large-scale adoption of AccuVein vein visualization ... Regional Medical Center is making vein visualization part of their standard of care. , ... importantly, helps our staff members locate a vein that will provide good access to ...
(Date:8/16/2017)... ... August 16, 2017 , ... A global leader in the treatment ... clinics in all 29 Indian states—bringing the country one step closer to eliminating clubfoot ... the nonprofit organization is on track to enroll 10,000 children in the clubfoot treatment ...
(Date:8/16/2017)... ... , ... Fusion Flix Inc., a Telly Award Winning, Non Profit Corporation has ... viewers in a partnership with the Amazon Video Direct Streaming Distribution Platform. , Their ... Ray disc in 2018. Proceeds will be going to further health research. , ...
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... TopConsumerReviews.com recently ... Lab Testing . , The healthcare industry in the United States has undergone ... are the days of needing to have a doctor’s order to get a blood ...
(Date:8/16/2017)... , ... August 16, 2017 , ... First Choice ... States, named Dr. Douglas J. Harrison, as the new Medical Director of its Sienna ... new facility Medical Director of our Sienna Plantation location,” said Dr. Michael (Derek) Caraway, ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... , Aug. 15, 2017  AOTI Inc. announced today that its ... Inc., has recently opened a New York City Office in ... of its unique Topical Wound Oxygen (TWO 2 ) homecare therapy. ... Accreditation Commission for Health Care (ACHC) under the company,s DMEPOS accreditation ... ...
(Date:8/8/2017)... Israel, Aug. 8, 2017  BioLineRx Ltd. (NASDAQ/TASE: BLRX), ... today reports its financial results for the second quarter ... during the second quarter 2017 and to date: ... clinical development programs for the Company,s lead project, BL-8040: ... pivotal study with BL-8040 as novel stem cell mobilization ...
(Date:8/7/2017)... Mich. , Aug. 7, 2017 Diplomat Pharmacy, ... of Joel Saban as president, effective Aug. 7, ... Urick has decided to pursue other interests and will ... "During his tenure, Paul has served us in multiple leadership ... Specialty Pharmacy in Jun. 2015 and has provided decisive, strategic ...
Breaking Medicine Technology: