Navigation Links
Ancient Chinese medicine may help chemotherapy patients
Date:8/18/2010

This release is also available in Chinese.

A centuries‑old traditional Chinese medicine may reduce the intestinal side effects of chemotherapy in cancer patients by stimulating gut cell division and reducing inflammation, a new study in mice suggests.

The research will appear in the Wednesday, 18 August issue of Science Translational Medicine, which is published by AAAS, the nonprofit science society.

Peonies and a pretty purple flower called skullcap, together with licorice and fruit from a buckthorn tree form Huang Qin Tang (pronounced Hu-ang Chin Tong), an ancient herbal medicine used in China to treat intestinal disorders such as diarrhea, nausea and vomiting. Recently, a Western-style phase 1/2 trial confirmed that this drug reduces gut damage caused by chemotherapy in colon and rectal cancer patients.

In the new study, Yung- Chi Cheng, along with Wing Lam and colleagues from Yale University School of Medicine and a company called PhytoCeutica, Inc. use a carefully prepared, lab formulation of this medicine (called PHY906) and show that the healing effects of this blend of plants arise from its ability to target numerous biological processes in mice.

"The reductionist approach to treating multiple side effects triggered by cancer chemotherapy or complicated disease may not be sufficient. Rigorous studies of the biology of traditional herbal medicines, which target multiple sites with multiple chemicals, could lead to the development of future medicines," said Cheng.

Dr. Cheng is a scientific founder of and has equity interest in PhytoCeutica, Inc., which develops traditional Chinese medicine into drugs for the treatment of cancer and that licenses PHY906 from Yale University. Additionally, two authors of this paper own stock in PhytoCeutica, Inc. Yale University holds a patent on the herbal composition PHY906 and its use in chemotherapy.

In the study, the researchers treated cancerous mice with chemotherapy, which shrank tumors but also caused massive destruction in the intestinal lining of the animals. After a few days of treatment with PHY906, the medicine restored the damaged intestinal linings in the mice. The team found that stem cell signaling molecules (known as Wnts) were present in higher than normal levels in the guts of the treated mice. Taking a closer look, the researchers discovered that PHY906 itself did not stimulate Wnt signaling, but that mixing PHY906 with a bacterial enzyme common in the gut triggered Wnt signaling, which drives the replacement of damaged intestinal stem cells with healthy ones.

In addition to replenishing healthy gut cells, the herbal medicine blocked the migration of inflammatory cells to the gut and reduced inflammation--effects that seem to be caused by multiple actions of PHY906. These results suggest that traditional Chinese medicine may be a model approach for drug developers, who are eagerly testing combinations of agents in the hope that they hope will work better than any one alone.

"We will continue to refine these processes to better study and understand the sophisticated nature of herbal medicines. Revisiting history may lead us to discovering future medicines," said Cheng.

PHY906 is currently only available for patients enrolled in a clinical trial. The authors caution that many herbal products claiming to be Huang Qin Tang may contain harmful or ineffective substitutes and should be avoided.


'/>"/>

Contact: Natasha Pinol
npinol@aaas.org
202-326-7088
American Association for the Advancement of Science
Source:Eurekalert

Related medicine news :

1. Ancient Chinese herbal recipe eases side effects of chemotherapy
2. Is Frequency the Future of Medicine or an Ancient Mystery Revealed?
3. Action of modern drug demonstrates how 2 ancient human systems interact
4. A new view of fossils: The behavior of ancient life forms
5. A Must-Hear Free Summer Seminar - Dr. Sherrill Sellman Reveals "Secrets for Getting in 'Summer Shape' with Ancient Herbs"
6. Strange Artifact Identified as Ancient Anti-Snoring Device
7. Ancient Minerals Topical Magnesium Oil Now Available in the UK
8. New partnership fosters broad scientific exchange with major Chinese university, hospital
9. Chinese Drywall Complaint Center Will Assist Homeowners In Tampa, Orlando, Houston, Austin & Montgomery Discover If They Have Knauf Chinese Drywall
10. Chinese Biopharmaceutical Association Successfully Holds 15th Annual Conference
11. Chinese systemic lupus erythematosus data reveal differences in epidemiology across continents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
(Date:10/13/2017)... ... 2017 , ... “America On The Brink”: the Christian history of the United ... the creation of published author, William Nowers. Captain Nowers and his wife, Millie, ... spent thirty years in the Navy. Following his career as a naval aviator ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 ... characterized by frequent cessation in breathing. Oral appliances can offer significant relief to ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... the demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults ... tested to meet the highest standard. , These products are also: Gluten ...
(Date:10/12/2017)... ... , ... The American College of Medical Informatics (ACMI) will present the 2017 ... Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is ... pioneer in the field of medical informatics, this prestigious award is presented to an ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... , Oct. 4, 2017 ... single-use, self-contained, illuminating medical devices, today announced regulatory ... Health Surveillance Agency (or Agência Nacional de Vigilância ... first single-use, cordless surgical retractor with integrated LED ... optimal access, illumination and exposure of a tissue ...
(Date:10/2/2017)...  Eli Lilly and Company (NYSE: LLY ... quarter of 2017 on Tuesday, October 24, 2017. Lilly ... with the investment community and media to further detail ... will begin at 9 a.m. Eastern time. Investors, media ... of the conference call through a link that will ...
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the European ... system called the HORIZON at MIBio 2017 in Cambridge, ... and visible particulate matter in biopharmaceutical samples with unprecedented speed and ... the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
Breaking Medicine Technology: