Navigation Links
Ancient Chinese medicine may help chemotherapy patients
Date:8/18/2010

This release is also available in Chinese.

A centuries‑old traditional Chinese medicine may reduce the intestinal side effects of chemotherapy in cancer patients by stimulating gut cell division and reducing inflammation, a new study in mice suggests.

The research will appear in the Wednesday, 18 August issue of Science Translational Medicine, which is published by AAAS, the nonprofit science society.

Peonies and a pretty purple flower called skullcap, together with licorice and fruit from a buckthorn tree form Huang Qin Tang (pronounced Hu-ang Chin Tong), an ancient herbal medicine used in China to treat intestinal disorders such as diarrhea, nausea and vomiting. Recently, a Western-style phase 1/2 trial confirmed that this drug reduces gut damage caused by chemotherapy in colon and rectal cancer patients.

In the new study, Yung- Chi Cheng, along with Wing Lam and colleagues from Yale University School of Medicine and a company called PhytoCeutica, Inc. use a carefully prepared, lab formulation of this medicine (called PHY906) and show that the healing effects of this blend of plants arise from its ability to target numerous biological processes in mice.

"The reductionist approach to treating multiple side effects triggered by cancer chemotherapy or complicated disease may not be sufficient. Rigorous studies of the biology of traditional herbal medicines, which target multiple sites with multiple chemicals, could lead to the development of future medicines," said Cheng.

Dr. Cheng is a scientific founder of and has equity interest in PhytoCeutica, Inc., which develops traditional Chinese medicine into drugs for the treatment of cancer and that licenses PHY906 from Yale University. Additionally, two authors of this paper own stock in PhytoCeutica, Inc. Yale University holds a patent on the herbal composition PHY906 and its use in chemotherapy.

In the study, the researchers treated cancerous mice with chemotherapy, which shrank tumors but also caused massive destruction in the intestinal lining of the animals. After a few days of treatment with PHY906, the medicine restored the damaged intestinal linings in the mice. The team found that stem cell signaling molecules (known as Wnts) were present in higher than normal levels in the guts of the treated mice. Taking a closer look, the researchers discovered that PHY906 itself did not stimulate Wnt signaling, but that mixing PHY906 with a bacterial enzyme common in the gut triggered Wnt signaling, which drives the replacement of damaged intestinal stem cells with healthy ones.

In addition to replenishing healthy gut cells, the herbal medicine blocked the migration of inflammatory cells to the gut and reduced inflammation--effects that seem to be caused by multiple actions of PHY906. These results suggest that traditional Chinese medicine may be a model approach for drug developers, who are eagerly testing combinations of agents in the hope that they hope will work better than any one alone.

"We will continue to refine these processes to better study and understand the sophisticated nature of herbal medicines. Revisiting history may lead us to discovering future medicines," said Cheng.

PHY906 is currently only available for patients enrolled in a clinical trial. The authors caution that many herbal products claiming to be Huang Qin Tang may contain harmful or ineffective substitutes and should be avoided.


'/>"/>

Contact: Natasha Pinol
npinol@aaas.org
202-326-7088
American Association for the Advancement of Science
Source:Eurekalert

Related medicine news :

1. Ancient Chinese herbal recipe eases side effects of chemotherapy
2. Is Frequency the Future of Medicine or an Ancient Mystery Revealed?
3. Action of modern drug demonstrates how 2 ancient human systems interact
4. A new view of fossils: The behavior of ancient life forms
5. A Must-Hear Free Summer Seminar - Dr. Sherrill Sellman Reveals "Secrets for Getting in 'Summer Shape' with Ancient Herbs"
6. Strange Artifact Identified as Ancient Anti-Snoring Device
7. Ancient Minerals Topical Magnesium Oil Now Available in the UK
8. New partnership fosters broad scientific exchange with major Chinese university, hospital
9. Chinese Drywall Complaint Center Will Assist Homeowners In Tampa, Orlando, Houston, Austin & Montgomery Discover If They Have Knauf Chinese Drywall
10. Chinese Biopharmaceutical Association Successfully Holds 15th Annual Conference
11. Chinese systemic lupus erythematosus data reveal differences in epidemiology across continents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... 2016 , ... The ThedaCare Center for Healthcare Value is ... April 5-7. The series is a multi-day, multi-workshop event designed to teach leaders ... broad range of topics, including coaching skills, the scientific method of problem solving ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Every winter, someone ... This winter the West Penn Burn Center, part of the Allegheny Health ... to bring you the “Space Heaters Need Space” campaign. , “Space ...
(Date:2/12/2016)... ... February 12, 2016 , ... AssureVest Insurance Group, a locally ... a charity drive that will raise funds earmarked to purchase computers and software for ... School. , “My school is in a low-income area and has more than 60 ...
(Date:2/12/2016)... ... February 12, 2016 , ... Vail knee specialist Robert LaPrade, MD, ... in 2016 . The list consists of physicians establishing, leading and partnering with ambulatory ... , An Ambulatory Surgery Center, also known as an ASC, is a modern ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... metro area, celebrates the beginning of the latest charity campaign in their community ... through art. Donations to this worthy cause are currently being accepted at: ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , 12 februari 2016 AAIPharma ... toonaangevende leverancier van productie en ontwikkeling op ... kondigt vandaag een uitbreiding aan van steriele ... locatie in Charleston, SC ... tot meerdere recente investeringen. http://photos.prnewswire.com/prnh/20150806/256637LOGO ...
(Date:2/11/2016)... 2016 The primary goal of this research ... on the usage of liquid biopsy. Key information the ... - Timeframe of liquid biopsy adoption amidst future users ... organization type - Sample inflow to conduct liquid biopsy ... serum, and so on. - Correlation analysis of sample ...
(Date:2/11/2016)... OAKLAND, Calif. , Feb. 11, 2016  Walgreens ... stores across 39 states and Washington, D.C. ... in a move that was commended by shareholder advocacy organization ... President at As You Sow. "Many people hold on to ... options, which can have tragic consequences." --> ...
Breaking Medicine Technology: