Navigation Links
Anchoring ABL for a better fate
Date:8/27/2013

Chronic Myelogenous Leukemia (CML) is a cancer of the white blood cells that is most commonly found in adults and in the elderly. Its incidence has been estimated to be 1 to 2 in 100,000 people. CML was the first cancer to be associated with a genetic abnormality, known as the Philadelphia Chromosome, which 95% of all CML patients carry in their cells.

The Philadelphia Chromosome is formed by exchanges of material belonging to two distinct chromosomes, number 9 and number 22. To form the Philadelphia Chromosome, these two chromosomes break at very specific places, disrupting the BCR (in chromosome 22) and the ABL (in chromosome 9) genes that were otherwise normal. Juxtaposition of these two genes in the Philadelphia Chromosome creates an abnormal kinase tyrosine known as BCR/ABL, which is an enzyme associated with cell regulation. The Philadelphia Chromosome is associated with loss of cell control and presence of immortal cells, which leads to cancer.

In the 1990s, ST1-571 (known as imatinib or Gleevec), a new inhibitor of kinase tyrosine, was developed and tested against CML cells. Since then, the drug has been used as the first line of treatment in many patients, increasing survival rates and improving patients' quality of life. However, some patients develop resistance to the drug, which has fostered development of novel drugs that act on alternative sites on the BCR/ABL enzyme.

Aiming to gain in-depth knowledge about the mechanisms involved in ABL control in normal cells, a group led by Dr. Jerson Silva at the Federal University of Rio de Janeiro, Brazil used small angle X-ray scattering, nuclear magnetic resonance, and confocal microscopy to investigate the dynamics of the entire ABL regulatory unit. The study shows that activation of the protein releases intramolecular interactions between a regulatory unit found in the N-terminal region of the ABL, the so-called N Cap, and a number of molecular modules, and pushes ABL to anc
'/>"/>

Contact: Jerson Lima Silva
jerson@bioqmed.ufrj.br
55-212-562-6756
Publicase Comunicao Cientfica
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Diet Doc Now More Closely Tailors Its Medically Supervised Diet Plans Around Individual Patient Need, Providing an Opportunity to Live Longer & Feel Better Naturally
2. MillionaireMatch.com Develops New Mobile Apps Enabling Members To Attain Better Dating Service
3. Natural Body Defense Fights Inflammation Better With Its Improved All-natural Content
4. Nursing professor receives funding to better estimate child fatalities due to abuse and neglect
5. Elena Shea’s New Book Reveals Guide to Building Vitality for Better Health
6. Pionetics® Corporation Celebrates Water Quality Month by Sharing Passion for Better Drinking Water
7. New survey of young adults: 7.8 million gained new or better coverage through Affordable Care Act
8. Golf Fitness
9. How “Power Golf Training” Helps People Get Better Physical Health to Play Golf – Vinamy
10. Flexibility Exercises
11. How “Ageless Mobility” Helps People Get Better Physical Health - Vinamy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... sweetFrog Enterprises, ... The opening is now the 19th sweetFrog store located in the Lone Star State. ... of fastest growing companies in 2014. , The store, which opened July 1 at ...
(Date:7/2/2015)... Kenosha, WIsconsin (PRWEB) , ... July 02, 2015 ... ... Luminaires for the parking structure retrofit project at the University of Minnesota, they ... know is that it would also be an award-winning choice: the total energy ...
(Date:7/2/2015)... ... ... In 2012, Patrick Achebe realized that the gift of poetry was fully in him, as ... first poem, and three years later he was publishing an entire book of poetry. He ... world. "I have always believed that the best way to lift yourself up, is in ...
(Date:7/2/2015)... PEACHTREE CITY, GA (PRWEB) , ... July 02, ... ... or field sporting the newest shades of the SIGVARIS PERFORMANCE SOCKS. Since the ... physicians, fitness experts and athletic trainers. Their significant popularity has inspired four new, ...
(Date:7/2/2015)... ... July 02, 2015 , ... The ZAC Foundation, a national leader in ... important lessons on how to stay water safe with the help of a young ... by The ZAC Foundation co-founders, follows Zeke’s water safety journey. Zeke, who is ...
Breaking Medicine News(10 mins):Health News:sweetFrog Expands Texas Footprint with Location in Canton 2Health News:Kenall’s TekDek™ Helps University Achieve Award-Winning Energy Savings in Parking Structure Lighting Retrofit 2Health News:Patrick Achebe Releases Debut Book, Whispering Waves: Poems for Everyday Grace 2Health News:SIGVARIS is Sporting Four Brand New Colors in the Popular PERFORMANCE SOCK Product Line 2Health News:The ZAC Foundation Kicks Off Summer and July 4th Weekend with Complimentary Children’s E-Book on Water Safety 2Health News:The ZAC Foundation Kicks Off Summer and July 4th Weekend with Complimentary Children’s E-Book on Water Safety 3
... million US children and adolescents are overweight or obese. ... to decline in the United States, the disparity between ... to grow larger. These issues are addressed in a ... (April 2008), Active Living in Diverse and Disadvantaged Communities. ...
... feelings about Clinton, BOSTON, April 3, 2008 ... they are typically willing,to admit, according to newly released ... express about the U.S. Senator from New,York does not ... appear to be,very deep., Emotion Mining, a Massachusetts ...
... Highlight 2008 Additions to Co-Branded Healthy Eating Education Initiative ... ... Building upon its 2007 inaugural,public education campaign SPOT THE BLOCK, Cartoon Network ... expanded,edition of the online and on-air promotion to launch Monday, April 7. ...
... experts helping to develop first implantable and external ... pediatric ... of UPMC -- a national leader in the use of lifesaving,ventricular ... a collaboration that recently has been awarded a $2.3 million grant ...
... Toolkit Offers Resources for Payers, Providers, and ... The American,Association of Preferred Provider Organizations (AAPPO), ... (DMAA), today launched a diabetes,toolkit for PPO ... the,diabetes problem and identify effective strategies for ...
... (April 3, 2008) Choline, an essential nutrient found in foods ... risk of breast cancer, according to a study supported by ... to be published in The FASEB Journals print issue in ... that links egg consumption to a decreased risk of breast ...
Cached Medicine News:Health News:Active living in diverse and disadvantaged communities 2Health News:Active living in diverse and disadvantaged communities 3Health News:Voting for Clinton Evokes Deep-Seated Feelings of Insecurity 2Health News:Cartoon Network and the FDA to Launch Year II Expansion of SPOT THE BLOCK Nutrition Awareness Campaign on Monday, April 7 2Health News:Cartoon Network and the FDA to Launch Year II Expansion of SPOT THE BLOCK Nutrition Awareness Campaign on Monday, April 7 3Health News:Cartoon Network and the FDA to Launch Year II Expansion of SPOT THE BLOCK Nutrition Awareness Campaign on Monday, April 7 4Health News:Children's Hospital of Pittsburgh of UPMC Involved in Projects To Develop Nation's First Heart Assist Devices for Young Children 2Health News:Children's Hospital of Pittsburgh of UPMC Involved in Projects To Develop Nation's First Heart Assist Devices for Young Children 3Health News:AAPPO Releases Diabetes Toolkit to Spur Action on Better Diabetes Care 2Health News:AAPPO Releases Diabetes Toolkit to Spur Action on Better Diabetes Care 3Health News:Essential nutrient found in eggs reduces risk of breast cancer by 24 percent 2Health News:Essential nutrient found in eggs reduces risk of breast cancer by 24 percent 3
(Date:7/2/2015)... -- Konica Minolta, Inc. (Konica Minolta) ( Tokyo ... Technologica Ltda., an X-ray system equipment manufacturer based in ... Brazilian healthcare sales company, Konica Minolta Healthcare do ... Brazil market investment and growth With ... significant healthcare technical advancements and efficiencies are required. Aging ...
(Date:7/2/2015)... South Korea, July 2, 2015 ALPINION MEDICAL SYSTEMS ... E-CUBE Series ultrasound system. Developed to enhance user experience ... the E-CUBE 15 EX produces superb image quality. With ... in women,s health, general imaging, and shared service applications. ... latest in the renowned E-CUBE Series, the E-CUBE 15 ...
(Date:7/2/2015)... Wilson Therapeutics AB , a privately-held biopharmaceutical company, today ... of directors. The appointment was approved by the shareholders ... "We are delighted to welcome Hans to Wilson,s ... of Wilson Therapeutics. "Hans brings significant global biopharmaceutical industry ... contributions to the Company." Hans Schikan is ...
Breaking Medicine Technology:Konica Minolta Acquires Sawae, Enhancing Digital X-ray Diagnostic Imaging Systems in Brazil 2Konica Minolta Acquires Sawae, Enhancing Digital X-ray Diagnostic Imaging Systems in Brazil 3E-CUBE 15 EX from ALPINION Enhances User Experience and Patient Care 2E-CUBE 15 EX from ALPINION Enhances User Experience and Patient Care 3Wilson Therapeutics Appoints Hans Schikan to its Board of Directors 2
... The RX600 is a versatile, fully ... range of built-in traction facilities, a powered ... make it extremely versatile too. ,<br.,In fact ... general surgery as it is for traction ...
... orthopedic trauma procedures. Part of the ... trauma table top provides a complete, ... positioning and provides for skin or ... hip pinnings; femur, supine or lateral ...
... provides a non-invasive therapy for the ... of fresh fracture healing that you ... daily, or as prescribed by your ... fracture to be sufficiently healed to ...
... cannulated interference screws have a ... screw divergence. Screws are available ... lengths. Screws are supplied sterile, ... and 9mm dia. (screws are ...
Medicine Products: