Navigation Links
Anchoring ABL for a better fate
Date:8/27/2013

Chronic Myelogenous Leukemia (CML) is a cancer of the white blood cells that is most commonly found in adults and in the elderly. Its incidence has been estimated to be 1 to 2 in 100,000 people. CML was the first cancer to be associated with a genetic abnormality, known as the Philadelphia Chromosome, which 95% of all CML patients carry in their cells.

The Philadelphia Chromosome is formed by exchanges of material belonging to two distinct chromosomes, number 9 and number 22. To form the Philadelphia Chromosome, these two chromosomes break at very specific places, disrupting the BCR (in chromosome 22) and the ABL (in chromosome 9) genes that were otherwise normal. Juxtaposition of these two genes in the Philadelphia Chromosome creates an abnormal kinase tyrosine known as BCR/ABL, which is an enzyme associated with cell regulation. The Philadelphia Chromosome is associated with loss of cell control and presence of immortal cells, which leads to cancer.

In the 1990s, ST1-571 (known as imatinib or Gleevec), a new inhibitor of kinase tyrosine, was developed and tested against CML cells. Since then, the drug has been used as the first line of treatment in many patients, increasing survival rates and improving patients' quality of life. However, some patients develop resistance to the drug, which has fostered development of novel drugs that act on alternative sites on the BCR/ABL enzyme.

Aiming to gain in-depth knowledge about the mechanisms involved in ABL control in normal cells, a group led by Dr. Jerson Silva at the Federal University of Rio de Janeiro, Brazil used small angle X-ray scattering, nuclear magnetic resonance, and confocal microscopy to investigate the dynamics of the entire ABL regulatory unit. The study shows that activation of the protein releases intramolecular interactions between a regulatory unit found in the N-terminal region of the ABL, the so-called N Cap, and a number of molecular modules, and pushes ABL to anc
'/>"/>

Contact: Jerson Lima Silva
jerson@bioqmed.ufrj.br
55-212-562-6756
Publicase Comunicao Cientfica
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Diet Doc Now More Closely Tailors Its Medically Supervised Diet Plans Around Individual Patient Need, Providing an Opportunity to Live Longer & Feel Better Naturally
2. MillionaireMatch.com Develops New Mobile Apps Enabling Members To Attain Better Dating Service
3. Natural Body Defense Fights Inflammation Better With Its Improved All-natural Content
4. Nursing professor receives funding to better estimate child fatalities due to abuse and neglect
5. Elena Shea’s New Book Reveals Guide to Building Vitality for Better Health
6. Pionetics® Corporation Celebrates Water Quality Month by Sharing Passion for Better Drinking Water
7. New survey of young adults: 7.8 million gained new or better coverage through Affordable Care Act
8. Golf Fitness
9. How “Power Golf Training” Helps People Get Better Physical Health to Play Golf – Vinamy
10. Flexibility Exercises
11. How “Ageless Mobility” Helps People Get Better Physical Health - Vinamy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... York, NY (PRWEB) September 23, 2014 ... a moderate rate over the past five years. Growth ... health consciousness has encouraged Canadians to consume more fish ... has encouraged food retailers and food-service establishments to increase ... increasing industry revenue. Additionally, strong economic growth in much ...
(Date:9/23/2014)... (PRWEB) September 23, 2014 Oaksterdam University ... Today . In its first post, the University addresses ... and changing cannabis industry. , The cannabis industry is ... alone is expecting an 18-month boost of more than ... adult use pot sales. And, the new legal recreational ...
(Date:9/23/2014)... "The primary purpose of the CALL LIGHT CADDY is patient ... "Call lights are often found on the floor, lost in ... out of the patient's reach. In order to make sure ... it, I created this caddy." , She developed the CALL ... easy reach. The accessory ensures that the call device can ...
(Date:9/23/2014)... The University of California, Davis, and Academia Sinica, ... China (Taiwan), have entered into a collaborative agreement ... program that couples cutting-edge research with opportunities to ... new companies. , The agreement was signed Sept.12 ... research at UC Davis and President Chi-Huey Wong ...
(Date:9/23/2014)... 23, 2014 AttorneyOne.com, a recognized authority ... latest information from the FDA on Jalapeno Bagels ... its Private Label Jalapeno Bagels are recalled as they ... Publix Jalapeno Bagels were sold in the self-service ... , Taking into consideration the latest developments, AttorneyOne.com monitor ...
Breaking Medicine News(10 mins):Health News:Fish and Seafood Wholesaling in Canada Industry Market Research Report Now Available from IBISWorld 2Health News:Fish and Seafood Wholesaling in Canada Industry Market Research Report Now Available from IBISWorld 3Health News:Oaksterdam University Addresses "Why Quality Training Matters in a Growing Marijuana Industry" in First Blog Post 2Health News:Oaksterdam University Addresses "Why Quality Training Matters in a Growing Marijuana Industry" in First Blog Post 3Health News:Academia Sinica, UC Davis sign agreement on exchanges and tech transfer 2Health News:Publix Private Label Jalapeno Bagels Recalled: AttorneyOne Monitors and Keeps Consumers Informed 2
... there, experts warn , SUNDAY, Sept. 16 (HealthDay News) ... States occur at home but are preventable, according to ... From cleaning products to coat hangers, the average American ... accidents. Americans can take simple steps, such as wearing ...
... Lifestyle Experts - Plus TV Style, Expert ... Patients Through Live ... 15 People suffering from painful and,at times, embarrassing, ... Foundation officially launched the 2007 PATH program,-- Psoriatic Arthritis ...
... trouble, experts say , , SATURDAY, Sept. 15 (HealthDay News) -- ... or severe stomach pain is another matter that could signal ... People with the following symptoms need to see a doctor: ... pain lasting for hours or days; , pain that wakes ...
... 14 Aid provided by,The Prem Rawat Foundation has ... and their families who were victims of the flooding,earlier ... the flooding, caused by cyclones in this area last ... from their homes. The,Prem Rawat Foundation made a grant ...
... Ill., Sept. 14 The Board of,Directors of ... distributor and,supplier of disposable gloves and other products ... announced it would file a,Form 15 on or ... Exchange,Commission to deregister the Company,s common stock and ...
... HOUSTON, Sept. 14 The following is a,Statement by Oscar S. Wyatt, Jr.: "I,ve seen ... any politicians who want to,return those funds received from me, please return them in the form ... ... DeBakey Medical Foundation ...
Cached Medicine News:Health News:Eye Safety Begins at Home 2Health News:Empowerment Program Gets Patients on the PATH to Managing the Physical and Emotional Effects of Psoriatic Arthritis 2Health News:Empowerment Program Gets Patients on the PATH to Managing the Physical and Emotional Effects of Psoriatic Arthritis 3Health News:The Prem Rawat Foundation Supports Disaster-Relief Efforts in Mozambique 2Health News:AHPC Holdings, Inc. Announces Intent to Deregister Common Stock With Securities and Exchange 2
(Date:9/23/2014)... Sept. 23, 2014 The Pennsylvania State Police will ... 27, as part of National Prescription Drug Take-Back Day. ... Take-Back Day is a national initiative, conducted ... aimed at encouraging the public to dispose of expired, ... abuse and theft. From 10 a.m. to ...
(Date:9/23/2014)... Canada , September 23, 2014 ... and lifestyle related disorders and increasing number of foreign ... demand for probiotic in India ... as one of the most high growth potential markets ... concerns among consumers especially among the youth, changing food ...
(Date:9/23/2014)... 23, 2014  KemPharm, Inc., a clinical-stage specialty ... of proprietary new molecular entity (NME) prodrugs, announced ... (NOL) from Health Canada to begin clinical trials ... lead product candidate KP201 (benzhydrocodone hydrochloride and acetaminophen).  ... acute moderate to moderately severe pain. The Health ...
Breaking Medicine Technology:India Probiotic Market Pegged to Grow at Around 20% by 2019, Says TechSci Research 2India Probiotic Market Pegged to Grow at Around 20% by 2019, Says TechSci Research 3KemPharm Receives Health Canada Approval to Begin KP201 Clinical Trials in Canada 2KemPharm Receives Health Canada Approval to Begin KP201 Clinical Trials in Canada 3
... , MOUNTAIN VIEW, Calif. , Feb. 16 ... it will host an investor/analyst meeting on Thursday, February 18, 2010 ... New York City . , The meeting will include presentations from: , ... James Cassella , PhD - SVP, Research and Development, ...
... , LAWRENCEVILLE, N.J. , Feb. 16 ... announced today that Wayne S. Mulcahy , Ph.D., ... A wholly owned subsidiary of Princeton Pharma Holdings LLC, ... unique products in ophthalmology and orphan diseases. , ...
Cached Medicine Technology:Alexza Pharmaceuticals to Host 2010 Investor/Analyst Day on Thursday, February 18, 2010 2Alexza Pharmaceuticals to Host 2010 Investor/Analyst Day on Thursday, February 18, 2010 3Alexza Pharmaceuticals to Host 2010 Investor/Analyst Day on Thursday, February 18, 2010 4Aton Pharma Appoints Dr. Wayne Mulcahy to Vice President, Clinical Operations 2
... difficile Panel is an enzyme immunoassay used ... antigen (glutamate dehydrogenase) and toxin A in ... as an aid in the diagnosis of ... of the Triage Microbiology product line, designed ...
ELISA for the detection of C. difficile toxin A in stool specimens...
... fast, accurate, reliable and repeatable measurements. The ... excellent price. , , , Automatic ... Refractor provides highly accurate measurement of patients ... by pushing a button. Patient alignment is ...
... Tomey Pachymeter SP-3000 covers all needs regarding ... ophthalmic health care., ,Compact design, colored touch-screen ... to be an "easy-to-use unit.,The wide measurement ... gives you the possibility to measure very ...
Medicine Products: