Navigation Links
Ancestry plays vital role in nutrition and disease, study shows
Date:6/14/2011

WINSTON-SALEM, N. C., -- June 14, 2011 Over the past decade, much progress has been made regarding the understanding and promise of personalized medicine. Scientists are just beginning to consider the impact of gene-diet interactions in different populations in regards to disease prevention and treatment.

The latest research from Wake Forest Baptist Medical Center and the laboratories of Floyd H. "Ski" Chilton, Ph.D., professor of physiology and pharmacology and director of the Center for Botanical Lipids and Inflammatory Disease Prevention, and Rasika Mathias, Sc.D, assistant professor of medicine and epidemiology at Johns Hopkins University School of Medicine, reveals how humans of different ancestry process a certain type of fat called polyunsaturated (PUFA) fat.

Importantly, this work suggests that the dramatic increase in a particular type of fatty acid, omega-6 PUFAs, in the American diet, together with a genetic propensity, causes individuals of African descent to more efficiently convert these dietary PUFAs to long chain PUFAs in the human body. Long chain PUFA can then, in turn, be converted to inflammatory messengers. Increased inflammatory messengers have been associated with a variety of chronic diseases including cardiovascular disease, arthritis, allergies and asthma, and diabetes.

The research, described in a manuscript that appears online this month in BMC Genetics, with upcoming publication in The British Journal of Nutrition, finds that populations of African descent have a much higher frequency of the gene variants associated with the conversion of dietary, medium chain omega-6 PUFAs to long chain omega-6 PUFAs that then have the potential to increase inflammation. Medium chain omega-6 PUFAs are found in the American diet in very high concentrations in margarine, vegetable oils, animal fats and processed foods.

"I believe observations such as this begin to address the critical question of why western diets seem to differentially impact African Americans with cardiovascular disease and diabetes at a higher rate than their Caucasian counterparts," said Chilton.

The Centers for Disease Control and Prevention (CDC) reports that chronic diseases such as heart disease, cancer, and diabetes are the leading causes of death and disability in the United States, accounting for 70 percent of all deaths in the U.S. These chronic diseases also limit daily living for about 25 million people.

Chilton and other groups of scientists have shown that genetic variation in a small region of chromosome 11, known as the FADS cluster, plays a critical role in determining rates of PUFA metabolism in populations of European and Asian ancestry.

The current studies are the first to look at populations of African ancestry. Chilton initially suspected there would be differences when he found that African Americans have much higher circulating levels of a long chain omega-6 PUFA, arachidonic acid (AA), than European Americans. The current research indicates there is a great deal of genetic difference between people of African and European ancestry regarding their ability to make long chain PUFAs. This is concerning, said Chilton, because over the last 75 years, there has been a dramatic increase in the consumption of medium chain omega-6 PUFAs -- from an estimated 2.8 percent to nearly 8 percent of daily calorie intake.

"This is an important example of why it is critical to advance the field of personalized nutrition," Chilton said. "Understanding which nutrients may be healthy for one population, but not for another will be essential to optimizing public health."

Dietary recommendations made by major health organizations are typically generalized to multiple populations, but are often based on available data from studies that represent one or two human populations. With regard to PUFAs, the American Heart Association currently recommends that Americans increase dietary PUFA levels to 5 to 10 percent of dietary energy. Studies like these suggest that such recommendations may not apply or be healthy for all populations.

"It is critical to study groups such as African Americans because they bear a large proportion of the public health burden of many of the chronic complex diseases of inflammation," Chilton said.


'/>"/>

Contact: Bonnie Davis
bdavis@wakehealth.edu
336-716-4977
Wake Forest Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. No link between genetic ancestry, asthma response in African-Americans
2. Genetic Ancestry Data Improve Diagnosis in Asthma and Lung Disease
3. Jews Around the World Linked by Common Genetic Ancestry
4. Unemployment Plays Role in Early Deaths, Research Shows
5. New fusion gene plays role in some stomach cancers
6. UCLA study finds cholesterol regulator plays key role in development of liver scarring, cirrhosis
7. Researchers find brain insulin plays critical role in the development of diabetes
8. Parents Have Stronger Relationship When Dad Plays With Kids
9. For non-whites, geography plays key role in colon cancer screening
10. Protein involved in cystic fibrosis also plays role in emphysema, chronic lung disease
11. Age plays too big a role in prostate cancer treatment decisions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... 2016 , ... CURE Media Group, the nation’s leading digital and print media ... Lung Cancer in efforts to combat lung cancer, announced CURE Media Group President Michael ... Media Group is honored to team up with Upstage Lung Cancer in order to ...
(Date:12/8/2016)... ... ... With the increasing demand for dental implants, the National Association of Dental Laboratories ... and patients about the safety issues related to dental restorations. According to the American ... projected to reach $6.4 billion in 2018 with more than 30 million Americans missing ...
(Date:12/8/2016)... ... 2016 , ... David J. Dykeman , Ginger Pigott , and ... speak at DeviceTalks West, Dec. 12, 2016, at the Fairmont Newport Beach in California. ... firm’s global Life Sciences & Medical Technology Group have been featured speakers at every ...
(Date:12/8/2016)... ... ... Premier Fitness Camp (PFC) and The Chopra Center for Wellbeing announced today the ... their world headquarters of Omni La Costa Resort & Spa in San Diego. , ... loss, personal development, a healthy lifestyle, or mental and physical healing. The week-long wellness ...
(Date:12/8/2016)... ... December 08, 2016 , ... SunView ... customers and employees that are both engaging and easy to use. Coming off ... the software company revealed today its plans to roll out new AI-powered self-service ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 2016 Bodycad announced it has been ... accuracy, reproducibility and speed for 3D constructs via ... bone orthopaedic applications. These patents are critical to ... restorations based on each patient,s distinct anatomy. ... harnesses the world,s first suite of orthopaedic CAD/CAM ...
(Date:12/8/2016)... 2016  Pennsylvania Physician General Dr. Rachel ... Programs Gary Tennis released safe prescribing ... benzodiazepines, developed with the help of a task ... are frequently prescribed for anxiety or insomnia," said ... opioid pain medications, benzodiazepines pose a significant risk ...
(Date:12/8/2016)... , Dec. 8, 2016  Valeant Pharmaceuticals ... TSX: VRX) ("Valeant") today announced positive results from ... study to assess the safety and efficacy of ... treatment of plaque psoriasis. Within ... with moderate to severe psoriasis, IDP-118 showed statistical ...
Breaking Medicine Technology: