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Ancestral link places Mexican-Americans at greater risk for metabolic disease
Date:8/24/2012

nority Health and Health Disparities. It is the only cohort in the United States studying health disparities in a purely Mexican-American population, according to McCormick. Almost 2,600 individuals have been enrolled in the cohort and research results help to uncover the high levels of health disparities such as obesity, diabetes, heart disease and mental health conditions that greatly affect the Hispanic population. Researchers have also investigated the lack of access to health services based on low levels of health insurance among this population.

In the Diabetes Care study, CCHC samples were used to measure the genetic and ancestry components of a range of risk factors to chronic diseases including insulin resistance. Males with an ancestral link to the Amerindian tribes were more likely to have an increased risk of insulin resistance.

As part of this study, researchers genotyped 103 ancestry informative markers to determine ancestral links to three major continental populations of European, African and Amerindians in order to determine associations with several potential metabolic conditions linked to chronic disease including insulin resistance. Ancestral informative markers are described as DNA signatures of one's ancestral origin that can be used to explore the relationship between ancestry and specific health conditions. According to researchers, these relatively recently discovered DNA ancestry signatures are being used to identify clues to disease susceptibility that are passed down and hidden in our genes.

The Mexican-American population is genetically mixed with mainly European and Amerindian ancestries, according to the article. Researchers also identified associations between ancestral components and common metabolic problems including serum lipid levels, blood pressure and liver injury.

In a separate quantitative clinical and epidemiologic study published in the August issue of Preventing Chronic Disease
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Contact: Jade Waddy
jade.waddy@uth.tmc.edu
713-500-3307
University of Texas Health Science Center at Houston
Source:Eurekalert

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