Navigation Links
Analysis of Six Clinical Trials Finds EPZICOM(R) Effective in Treatment-Naive HIV Patients With Both High and Low Baseline Viral Loads
Date:8/7/2008

MEXICO CITY, Aug. 7 /PRNewswire-FirstCall/ -- GlaxoSmithKline (NYSE: GSK) announced that a retrospective analysis of six clinical trials found that anti-HIV regimens containing EPZICOM (abacavir + lamivudine) were effective in treatment-naive patients regardless of baseline viral loads. One of the trials analyzed was a large study comparing treatment with regimens containing EPZICOM versus regimens containing Truvada(R) (tenofovir DF + emtricitabine) in treatment-naive patients with both high and low baseline viral loads. The analysis was presented today at the 17th International AIDS Conference in Mexico City, Mexico.

GSK examined six clinical trials with 2,940 treatment-naive patients on regimens containing either EPZICOM or its individual components over 48 weeks of treatment, including the HEAT study, a head-to-head clinical trial comparing EPZICOM to Truvada. Patients were analyzed according to baseline viral load (<100,000c/mL being low and greater than or equal to 100,000c/mL being high) and efficacy was determined by time to virologic failure. The definition of virologic failure was similar to that utilized in the ACTG 5202 study. At 48 weeks, 87-95% of all patients in the analysis did not meet the definition for virologic failure. An additional retrospective analysis of the HEAT study found similar results in both EPZICOM- and Truvada-containing regimens regardless of baseline viral load.

The analysis was conducted after interim data from a single, ongoing study by the AIDS Clinical Trials Group (ACTG 5202) found results inconsistent with previous experience with EPZICOM. A routine review of ACTG 5202 by the data safety monitoring board (DSMB) found that although both the EPZICOM and Truvada treatment arms were effective in reducing HIV viral load, a statistically higher rate of protocol-defined virologic failure and protocol-defined safety endpoints were seen in patients with high screening viral loads in the EPZICOM-treatment arm. The
'/>"/>

SOURCE GlaxoSmithKline
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine news :

1. Kansas Health Policy Authority Awards Thomson Reuters Contract for Health Care Data Integration and Analysis Initiative
2. Next generation data analysis for next generation sequencing data
3. Analysis of cancer incidence, mortality and survival combined reveals encouraging European trends
4. Caris Diagnostics Providing KRAS Mutational Analysis for Colon Cancer Patients
5. The DataTrace(R) RF System, the Latest High Performance Radio Data Logger for Real-Time, Process Data Collection, Reporting, and Analysis Is Launched
6. Patient Data Analysis Report Finds More Than 75 Percent of Chronically Ill Patients Unable to Obtain Needed Healthcare Have Some Form of Insurance
7. Analysis of Millions of U.S. Births Shows Association Between Birth Defects and Preterm Birth
8. Data re-analysis shows drug finasteride reduces risk for most prostate cancers
9. Carnegie Mellon engineering researchers automate analysis of protein patterns
10. Queen Rania Launches Situation Analysis of Children in Jordan Highlighting Jordans Progress in Improving Quality of Life; 6 Ministers Commit to Further Improving Results
11. New analysis shows DAYTRANA offered ADHD symptom control for 12 months
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... January 22, 2015 Juvent Sports ( ... the 2015 PGA Merchandise Show to bestow a Juvent ... female amateur golfer, Arlene McKitrick. The award commemorated and ... golf tournament win. She won her first amateur tournament ...
(Date:1/22/2015)... 20 years, Dr. David Cruz of Cruz Chiropractic Care ... about every type of injury that can result from car accidents ... years, the team at Doctors on Liens has been ... With the combined breadth of experience between the two, ...
(Date:1/22/2015)... January 22, 2015 Yesterday, Senator ... (D-Concord) and Kristin Olsen (R-Modesto) were honored by ... in advancing biotechnology, biomedical science, medical device and ... each received the “2014 Life Sciences Champion” award ...
(Date:1/22/2015)... 22, 2015 Payday lending practices in ... and cause financial distress to the states that permit ... Howard University’s Center on Race and Wealth. , While ... activity, payday loans at the same time substantially depress ...
(Date:1/22/2015)... Compare-autoinsurance.org has released a new blog post presenting a ... insurance policy . , Some types of vehicles cannot be ... newly released blog post to see if their vehicle qualifies for ... are some of the cars that cannot be covered by a ...
Breaking Medicine News(10 mins):Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2
... any moment may be keyed to what they expect to ... -- People like to temper their emotions to the task ... the emotions are not pleasurable ones, a new report suggests. ... for example, when they expect to complete a confrontational task ...
... ,hands on, approach and strategic ... statement, BOSTON, April 4, 2008 The Board ... of Robert Hernreich to the,organization,s board of directors. Mr. ... officially took his place on the board in,late 2007., ...
... Put Medical Equipment Providers Out of Business and,Disrupt Services ... Disabled People,in Ohio, ARLINGTON, Va., April 4, 2008 ... (DME) scheduled to be,implemented in the Cincinnati and Cleveland, ... providers out of business and will likely disrupt,services for ...
... has been reported that highlights the problems that oxidative ... can generate in relation with the pathogenesis of Alzheimer,s ... throughout the world. The results of research carried out ... from the laboratory of Professor Dr. R.B. Maccioni of ...
... than 26,000 rushing in for acute care each year, study ... well is graceful and awe-inspiring, but one misstep or misplaced ... American children end up in hospital emergency rooms due to ... the April issue of Pediatrics . , "Gymnastics has ...
... Joint Commission Campaign Urges Patients to Take an ... Ill., April 4, 2008 ,Understanding the often complex ... you can be difficult, and the consequences of,misunderstanding ... Joint Commission is launching a national campaign to ...
Cached Medicine News:Health News:Study Shows Anger Has Its Uses 2Health News:Global Action Board of Directors Announces Addition of Newest Member, Robert Hernreich 2Health News:Errors Plague Medicare 'Competitive Bidding' Program in Ohio, Says American Association for Homecare 2Health News:Errors Plague Medicare 'Competitive Bidding' Program in Ohio, Says American Association for Homecare 3Health News:Errors Plague Medicare 'Competitive Bidding' Program in Ohio, Says American Association for Homecare 4Health News:Redox-active iron is a sensor of cognitive impairment associated with Alzheimer's disease 2Health News:Young Gymnasts Tumbling and Vaulting Their Way to the ER 2Health News:Young Gymnasts Tumbling and Vaulting Their Way to the ER 3Health News:'Understanding Your Caregivers' Promotes Health Literacy 2Health News:'Understanding Your Caregivers' Promotes Health Literacy 3
(Date:1/23/2015)... 23, 2015 More than a third of reproductive-aged women ... with private insurance, filled a prescription for an opioid pain ... this week,s Morbidity and Mortality Weekly Report (MMWR). ... treat moderate to severe pain.  They are also found in ...
(Date:1/23/2015)... , Jan. 23, 2015  Now available for sale, ... 7,849,611) support that prevents ankle sprains by cushioning the ... it fits securely around the outside of any shoe ... & comfort while still offering protection against sprains. With ...
(Date:1/23/2015)... , Jan. 23, 2015  CytoSorbents Corporation (NASDAQ ... its CytoSorb® extracorporeal cytokine adsorber to reduce deadly ... the receipt of $385,642, net of transaction costs, ... the Technology Business Tax Certificate Transfer Program sponsored ...
Breaking Medicine Technology:Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3
... body temperatures of newborns with temporal artery thermometry (forehead ... (under arm) thermometry, the clinically recommended method for this ... new study reported in Advances in Neonatal Care ... clinical analysis evaluating the accuracy of temporal artery thermometry ...
... BB&T Capital Markets served as the exclusive financial advisor ... developer, manufacturer and marketer of therapeutic footwear and related ... Global, an international provider of medical device solutions for ... Vista, Calif. Dr. Comfort generated net sales of $71.8 ...
Cached Medicine Technology:Study Finds Exergen Temporal Artery Thermometry Accurate on Newborns 2Study Finds Exergen Temporal Artery Thermometry Accurate on Newborns 3BB&T Advises Dr. Comfort on Its Sale to DJO Global in Transaction Valued at $254.6 Million 2
Scoville Ruptured Disc Curettes, length 10" (254 mm), cup size 4 x 10 mm....
PG Magnum Ring Curettes, total length 12.6" (32 cm), handle length 7.8" (20 cm), handle diameter 1.12" (3 cm), working distance 4.7" (12 cm), dual-coned, precision sharpened rings....
XL Cervical Curette comes with a bayonet design and satin black handles having instrument length 9.5" (24 cm), working distance4.1" (10.4 cm) and handle width 0.6" (1.5 cm)....
Bone Curette, 160 mm...
Medicine Products: