Navigation Links
Analysis Sheds Light on Protein's Role in Cancer

Scientists make strides in finding ways to slow tumor growth

FRIDAY, June 5 (HealthDay News) -- A protein called PHD2 that regulates blood vessel growth is often found at lower-than-normal levels in tumors, say researchers who analyzed levels of the protein in tumor samples and healthy tissue.

When they blocked the expression of PHD2, researchers at Stanford University School of Medicine in California found that human cancer cells grew more quickly when implanted into mice and there was an increase in the number of blood vessels feeding the tumors. To grow and spread, tumors require a good supply of blood, the study authors noted in a Stanford news release.

Further investigation revealed that blocking PHD2 expression increased levels of two other proteins -- IL-8 and angiogenin -- that play an important role in blood vessel formation. Blocking the activity of these proteins may slow tumor growth, the researchers said.

"Prior to this study, it was unclear which of the many proteins involved in vessel growth, or angiogenesis, should be targeted. But now we know they play a predominant role in tumor growth," Amato Giaccia, a professor of radiation oncology, said in the release.

The findings are published in the June 2 issue of Cancer Cell.

In the next phase of their research, Giaccia and colleagues will study whether mice that lack PHD2 expression develop more aggressive tumors, and whether blocking IL-8 or angiogenin slows tumor growth.

More information

The American Cancer Society has more about cancer.

-- Robert Preidt

SOURCE: Stanford University School of Medicine, news release, June 1, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Ambry Genetics Announces Launch of Chromosomal Microarray to Offer Whole Genome Analysis
2. Evidence-Based Analysis of Aspartame Research
3. Ingenuity and Integromics Offer Integration for Comprehensive Genomics Analysis
4. Milliman Analysis: Preparing for Mental Health Parity
5. NSD Bio Group, LLC Selected By U.S. - China Economic & Security Review Commission for Analysis of Chinas Pharma Supply Chain on U.S. Pharmaceuticals
6. Medicaid Health Plans Provide Cost Savings to States and High Quality and Value to Beneficiaries, New Analysis Shows
7. Transplant patients have worse cancer outcomes, analysis shows
8. Retrospective Analysis Finds Treatment of Cancer Chemotherapy Patients With Epoetin Alfa Associated With Lower Drug Cost Than Darbepoetin Alfa
9. Analysis of FDA Adverse Events Data Reveals at Least 106 Serious Conditions Reported Among Reglan Users
10. Webcast Alert: Release of Economic Analysis Revealing $734 Billion in Savings Produced by Using Generic Medicines in 1999 - 2008
11. New data analysis shows possible link between childhood obesity and allergies
Post Your Comments:
Related Image:
Analysis Sheds Light on Protein's Role in Cancer
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder ... of ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership ... rules. It also provides a forum to network with elder law attorneys nationwide,” said ...
(Date:10/13/2017)... NY (PRWEB) , ... October 13, 2017 , ... Ellevate ... people in business to advocate for action towards gender equality at their inaugural Summit ... from around the globe, and reached a social audience of over 3 million. To ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/12/2017)... CA (PRWEB) , ... October 12, 2017 , ... ... Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent technology. ... a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can ...
(Date:10/12/2017)... ... 12, 2017 , ... The American College of Medical Informatics (ACMI) will present ... the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... Collen, a pioneer in the field of medical informatics, this prestigious award is presented ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Pa. , Oct. 12, 2017 ... leader in innovative solutions for injectable drug administration, today ... before the market opens on Thursday, October 26, 2017, ... the results and business expectations at 9:00 a.m. Eastern ... (U.S.) or 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)... , Oct. 11, 2017  True Health, a ... amplified its effort during National Breast Cancer Awareness ... cancer risks. ... Oncology calculated that more than 10 million American ... mutations in BRCA1 or BRCA2 and have not had ...
(Date:10/10/2017)... Oct. 10, 2017   West Pharmaceutical Services, Inc. ... for injectable drug administration, today shared the results of ... for improving the intradermal administration of polio vaccines. The ... Summit in May 2017 by Dr. Ondrej Mach ... World Health Organization (WHO), and recently published in the ...
Breaking Medicine Technology: