Navigation Links
Analysis Finds Clinical Trials Often Small, of Poor Quality
Date:5/2/2012

By Randy Dotinga
HealthDay Reporter

TUESDAY, May 1 (HealthDay News) -- A new analysis of registered U.S. clinical trials -- the research that seeks to determine if medical treatments and prevention strategies work -- finds that many are small and of poor quality.

Studies of cancer treatments, in particular, often fail to follow the highest standards of medical research, the analysis found. Meanwhile, a full 7 percent of the studies didn't bother to mention their purpose, while others failed to provide other important details.

"We think expert groups need to start scrutinizing the database more and really examine the quality of the trials one by one," said report author Dr. Robert Califf, vice chancellor for clinical and translational research at Duke University. "For the first time, we have a chance to look at the entire universe [of clinical research] and we can see that we can do better."

Califf and his colleagues examined the Clinicaltrials.gov database, which includes medical research studies that enroll people. By law in the United States, many kinds of studies must be registered in this database.

As the law has been strengthened, the number of registered trials has grown. A total of 40,970 trials were registered between October 2007 and September 2010, compared to 28,881 trials registered over the previous three years.

"In the past, there would be a lot of studies done, but many would never be studied or reported anywhere," Califf explained. "Sometimes you'd only see the ones that were positive. Now, we have much more accurate information."

However, the analysis found that most clinical research in the database isn't very extensive, raising questions about reliability.

The new report says 62 percent of the trials from 2007-2010 were small, with 100 or fewer participants. Only 4 percent had more than 1,000 participants.

"There are 330 new clinical trials being registered every week, and a number of them are very small and probably not as high quality as they could be," Califf said.

Ideally, medical studies compare randomly chosen groups of people to each other, with one group getting a treatment and the other getting another treatment or an inactive placebo. However, 65 percent of cancer studies didn't randomize their participants, compared to 26 percent of cardiovascular studies.

The finding raises questions about whether cancer studies should be done differently, Califf said.

One expert agreed that the quality of medical research in the United States is lacking.

It's clear that "a lot of studies are of poor quality," said Kay Dickersin, director of the Center for Clinical Trials at Johns Hopkins Bloomberg School of Public Health in Baltimore and co-author of an editorial accompanying the report.

That's a problem because the medical world relies on research not only to determine whether new medications work but also to figure out guidelines for common medical procedures, such as whether people should get colonoscopies, Dickersin said.

Dickersin noted that the federal database includes incomplete information about some studies. For example, 7 percent of studies registered from 2007-2010 didn't mention their purpose, as is required; 4 percent didn't say how many volunteers would take part.

The lack of correct data slows down researchers who are trying to analyze a swath of research for studies known as meta-analyses that help doctors figure out guidelines, Dickersin explained.

The report appears in the May 2 issue of the Journal of the American Medical Association.

More information

The U.S. National Library of Medicine has a fact sheet about clinicaltrials.gov.

SOURCES: Robert Califf, M.D., vice chancellor, clinical and translational research, Duke University, Durham, N.C.; Kay Dickersin, Ph.D., professor and director, Center for Clinical Trials, and director, U.S. Cochrane Center, Johns Hopkins Bloomberg School of Public Health, Baltimore; May 2, 2012, Journal of the American Medical Association


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Kaiser Analysis Finds Record Medicaid Enrollment Growth in 2009
2. New approach to immune cell analysis seen as first step to better distinguish health and disease
3. National Center for Policy Analysis and Salem Radio Network Deliver One Million Emails to Congress to Stop ObamaCare
4. Pregnancy for breast cancer survivors: Meta-analysis reveals it is safe and could improve survival
5. Improved device provides more rapid, comprehensive analysis of circulating tumor cells
6. Know What Works with Semantic Design's Test Coverage Analysis Tool for C#/.Net
7. Social Media Network Analysis Workshop
8. University of Miami College of Engineering to develop new methods for data analysis
9. Biosensor chip enables high-sensitivity protein analysis for disease diagnosis
10. MetaGeek Announces Chanalyzer Pro Spectrum Analysis Software for Wi- Spy, Adds Device Classification, Device Finder and Automated Reports
11. Voice Analysis May Allow Early Detection of Parkinsons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Analysis Finds Clinical Trials Often Small, of Poor Quality 
(Date:9/1/2020)... ... September 01, 2020 , ... ... specialty fellowship training in aesthetic surgery of the face, breast, and body. In ... only female-owned premier boutique plastic surgery and aesthetic practice in Southwest Florida. Dr. ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... recently donated 1,400 N95 face masks to medical first responders across the United ... to make donations of personal protective equipment (PPE) medical centers , ...
(Date:8/31/2020)... , ... August 31, 2020 , ... ... support services to dental groups in the United States, today announced the grand ... of Beaumont, CA. , Patients will enjoy convenient hours, a comfortable office, ...
(Date:8/31/2020)... ... 2020 , ... Dr. Chang has over 20 years of ... developmental disabilities, as well as supporting staff in caring for patients and families. ... and staff development. She joined the company in 2015 as Chief of Clinical ...
(Date:8/28/2020)... ... August 28, 2020 , ... WHAT , Hespiro™ is a ... respiratory conditions, including COVID-19, while reducing the need for scarce mechanical ventilators. It ... gas and scrubs it free of carbon dioxide in a completely closed “rebreather” ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... August 31, 2020 , ... Welltech1, the first ... they have invested $400,000 in PopBase, one of two start-ups that beat 152 ... Wellness Institute (GWI). , The competition was part of the GWI’s The ...
(Date:8/28/2020)... ... 2020 , ... Cano Health, LLC, a leading population health ... Antonio is happy to announce that it has selected Tejano musician Jay Perez ... will serve as community advisor, advertising talent, and creative consultant for Cano Health, ...
(Date:8/27/2020)... ... 2020 , ... Austin Oral Surgery – an oral and maxillofacial surgery practice ... DDS, MD, has joined the practice. An accomplished oral and maxillofacial surgeon, Dr. Szalay’s ... scheduled to open this fall. The new office is slated for 1601 E. Pflugerville ...
Breaking Medicine Technology: