Navigation Links
An important discovery at the Montreal Heart Institute: A new approach to treat the most common heart valve disease in Western countries
Date:7/18/2013

Montreal, Canada, July 18, 2013 A study conducted by the team of Dr. Jean-Claude Tardif, Director of the Research Centre at the Montreal Heart Institute (MHI), has led to the discovery of a new approach to treat aortic valve stenosis through the administration of a compound that prevents valve deterioration and can even reverse the progression of the disease. A condition that is characterized by a narrowing of the aortic valve and that affects approximately 150,000 Canadians , aortic valve stenosis is the most common type of heart valve disease in Western countries. The results of this study were published in the British Journal of Pharmacology on July 15, 2013.

This study conducted in mice suffering from aortic valve stenosis showed successful outcomes with infusions of a compound that mimics HDL (high-density lipoprotein), which is often referred to as "good cholesterol." This treatment could help open narrowed aortic valves, avoid the major complications of aortic valve stenosis (including the need for heart surgery), and prevent heart failure and sudden death.

A less invasive option

"These results are extremely encouraging, as they allow us to hope that this type of treatment will work for people who suffer from aortic valve stenosis. If so, it will represent a brand-new treatment option that may even prevent open-heart surgery to replace valves damaged by stenosis," said Dr. Jean-Claude Tardif. "This treatment may be an alternative to a procedure that is complex, risky and very invasive for patients." Valve replacement surgery is currently the primary treatment option for this condition, with 13,000 surgeries conducted on average each year in Canada .

A growing incidence

Especially common in people over the age of 65, aortic valve stenosis can also affect people who are overweight, eat a high-fat diet, are diabetic or have a congenital abnormality. "In light of the aging of the population and alarming data on excess weight, diabetes, lifestyle and the diet of the population in general, this disease represents a major public health problem," stressed Dr. Tardif.

More details about the MHI study

In this study, mice were put on a cholesterol-enriched diet until aortic valve stenosis was detected using echocardiography (a medical imaging ultrasound system used in humans). The animals were then divided into two groups: a control group that received saline infusions and a treatment group that received infusions of a compound that mimics good cholesterol (an apoA-I mimetic peptide) for two weeks.

These results were particularly impressive as, after only 28 days of treatment, the aortic valve opened more fully in the treatment group compared to the control group. The aortic wall in the treatment group had also reduced in thickness compared to the control group.

Furthermore, microscopic analysis also revealed that the extent of the scar lesions (or accumulated collagen) in the valves was significantly smaller in the treated subjects than in the control subjects.


'/>"/>

Contact: Lauren Guay
lauren.guay@edelman.com
514-315-1970
Montreal Heart Institute
Source:Eurekalert

Related medicine news :

1. US Drug Watchdog Now Calls Their DePuy Pinnacle Hip Implant Blood Test Initiative Vital And They Urge Recipients To Call Them For Instructions About This Important Test
2. New Mirena IUD Complications Lawsuits Allegations Report: Resource4thePeople Reports Important Multidistrict Litigation Hearing Scheduled
3. Neurosurgery publishes findings of 3 important studies in June issue
4. Dr. Kanani, Woodland Hills Dentist: Tongue Brushing May Be as Important as Tooth Brushing
5. Latest Pradaxa Internal Bleeding Problem Allegation Lawsuits Update; Resource4thePeople Reports Judge Schedules Important Hearing
6. Alleged NuvaRing Blood-Clotting Lawsuits Update: Resource4thePeople Reports Important Hearing Scheduled for July
7. Alleged Zoloft Birth Defects Lawsuits Report from Resource4thePeople: Federal Judge Schedules Important Status Conference
8. Medical Practice Management Important as Aging Baby Boomers and Affordable Care Act Expand Pool of Patients: Appointment-Plus
9. Jean LaMantia Registered Dietitian, Cancer Survivor and Author Announces An Important Partnership to Help Put a Much-Needed Resource Into the Hands of Cancer Patients Across the Nation
10. Researchers take important step in unlocking what causes congenital heart disease
11. Scott Tischler of Tischler Brothers Fitness unveils the 8 reasons why water is so important
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... , ... April 30, 2016 ... ... CBC News on April 4th, 2016 questioned the use of the HyProCure ... EOTTS-HyProCure as “a controversial procedure.” EOTTS-HyProCure is a minimally invasive procedure performed, ...
(Date:4/29/2016)... ... April 29, 2016 , ... In an article published April ... enthusiasm for Botox and lip injections, which she underwent in order to feel more ... Music and Arts Festival. The article explains that Ms. Mirmelli’s situation is not unique; ...
(Date:4/29/2016)... Georgia (PRWEB) , ... April 29, 2016 , ... On ... rural hospitals across the Southeast, celebrated the signature of Gov. Nathan Deal on SB ... Rep. Geoff Duncan (R - Cumming), offers a 70% tax credit to individuals and ...
(Date:4/29/2016)... ... 29, 2016 , ... Coast Dental Fort Stewart is celebrating its grand opening ... the Exchange Furniture Mall at 112 Vilseck Road in Fort Stewart. There will be ... attendees will have the opportunity to meet general dentists Thomas Richards, DDS, and Josh ...
(Date:4/29/2016)... ... April 29, 2016 , ... World ... the Gyrociser, an exercise invention which aids in proper muscle development. , "The ... CEO and Creative Director of World Patent Marketing. "Globalization has threatened the future ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... New Jersey , April 29, 2016 /PRNewswire/ ... Software Suite for Life Sciences, Product Development Capabilities ... Global Life Science Customer Base . ... solutions provider, today announced the acquisition of Skura ... a global leader in adaptive sales enablement technology ...
(Date:4/28/2016)...  While Abbott,s announced purchase of St. Jude ... and stent business, healthcare research firm Kalorama Information ... into patient monitoring.  Kalorama said that patient monitoring ... with double-digit growth expected the next 5 years, ... Patient Monitoring . Abbott Laboratories agreed to ...
(Date:4/28/2016)... -- Treato , the single largest ... that it has been named a Cool Vendor by ... Sciences, 2016, Stephen Davies , Michael ... life-science- oriented analytics, algorithms and smart machine technology in ... medication ingestion, and analyze unstructured information.   ...
Breaking Medicine Technology: