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An important discovery at the Montreal Heart Institute: A new approach to treat the most common heart valve disease in Western countries
Date:7/18/2013

Montreal, Canada, July 18, 2013 A study conducted by the team of Dr. Jean-Claude Tardif, Director of the Research Centre at the Montreal Heart Institute (MHI), has led to the discovery of a new approach to treat aortic valve stenosis through the administration of a compound that prevents valve deterioration and can even reverse the progression of the disease. A condition that is characterized by a narrowing of the aortic valve and that affects approximately 150,000 Canadians , aortic valve stenosis is the most common type of heart valve disease in Western countries. The results of this study were published in the British Journal of Pharmacology on July 15, 2013.

This study conducted in mice suffering from aortic valve stenosis showed successful outcomes with infusions of a compound that mimics HDL (high-density lipoprotein), which is often referred to as "good cholesterol." This treatment could help open narrowed aortic valves, avoid the major complications of aortic valve stenosis (including the need for heart surgery), and prevent heart failure and sudden death.

A less invasive option

"These results are extremely encouraging, as they allow us to hope that this type of treatment will work for people who suffer from aortic valve stenosis. If so, it will represent a brand-new treatment option that may even prevent open-heart surgery to replace valves damaged by stenosis," said Dr. Jean-Claude Tardif. "This treatment may be an alternative to a procedure that is complex, risky and very invasive for patients." Valve replacement surgery is currently the primary treatment option for this condition, with 13,000 surgeries conducted on average each year in Canada .

A growing incidence

Especially common in people over the age of 65, aortic valve stenosis can also affect people who are overweight, eat a high-fat diet, are diabetic or have a congenital abnormality. "In light of the aging of the population
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Contact: Lauren Guay
lauren.guay@edelman.com
514-315-1970
Montreal Heart Institute
Source:Eurekalert

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