Navigation Links
An important discovery at the Montreal Heart Institute: A new approach to treat the most common heart valve disease in Western countries
Date:7/18/2013

Montreal, Canada, July 18, 2013 A study conducted by the team of Dr. Jean-Claude Tardif, Director of the Research Centre at the Montreal Heart Institute (MHI), has led to the discovery of a new approach to treat aortic valve stenosis through the administration of a compound that prevents valve deterioration and can even reverse the progression of the disease. A condition that is characterized by a narrowing of the aortic valve and that affects approximately 150,000 Canadians , aortic valve stenosis is the most common type of heart valve disease in Western countries. The results of this study were published in the British Journal of Pharmacology on July 15, 2013.

This study conducted in mice suffering from aortic valve stenosis showed successful outcomes with infusions of a compound that mimics HDL (high-density lipoprotein), which is often referred to as "good cholesterol." This treatment could help open narrowed aortic valves, avoid the major complications of aortic valve stenosis (including the need for heart surgery), and prevent heart failure and sudden death.

A less invasive option

"These results are extremely encouraging, as they allow us to hope that this type of treatment will work for people who suffer from aortic valve stenosis. If so, it will represent a brand-new treatment option that may even prevent open-heart surgery to replace valves damaged by stenosis," said Dr. Jean-Claude Tardif. "This treatment may be an alternative to a procedure that is complex, risky and very invasive for patients." Valve replacement surgery is currently the primary treatment option for this condition, with 13,000 surgeries conducted on average each year in Canada .

A growing incidence

Especially common in people over the age of 65, aortic valve stenosis can also affect people who are overweight, eat a high-fat diet, are diabetic or have a congenital abnormality. "In light of the aging of the population and alarming data on excess weight, diabetes, lifestyle and the diet of the population in general, this disease represents a major public health problem," stressed Dr. Tardif.

More details about the MHI study

In this study, mice were put on a cholesterol-enriched diet until aortic valve stenosis was detected using echocardiography (a medical imaging ultrasound system used in humans). The animals were then divided into two groups: a control group that received saline infusions and a treatment group that received infusions of a compound that mimics good cholesterol (an apoA-I mimetic peptide) for two weeks.

These results were particularly impressive as, after only 28 days of treatment, the aortic valve opened more fully in the treatment group compared to the control group. The aortic wall in the treatment group had also reduced in thickness compared to the control group.

Furthermore, microscopic analysis also revealed that the extent of the scar lesions (or accumulated collagen) in the valves was significantly smaller in the treated subjects than in the control subjects.


'/>"/>

Contact: Lauren Guay
lauren.guay@edelman.com
514-315-1970
Montreal Heart Institute
Source:Eurekalert

Related medicine news :

1. US Drug Watchdog Now Calls Their DePuy Pinnacle Hip Implant Blood Test Initiative Vital And They Urge Recipients To Call Them For Instructions About This Important Test
2. New Mirena IUD Complications Lawsuits Allegations Report: Resource4thePeople Reports Important Multidistrict Litigation Hearing Scheduled
3. Neurosurgery publishes findings of 3 important studies in June issue
4. Dr. Kanani, Woodland Hills Dentist: Tongue Brushing May Be as Important as Tooth Brushing
5. Latest Pradaxa Internal Bleeding Problem Allegation Lawsuits Update; Resource4thePeople Reports Judge Schedules Important Hearing
6. Alleged NuvaRing Blood-Clotting Lawsuits Update: Resource4thePeople Reports Important Hearing Scheduled for July
7. Alleged Zoloft Birth Defects Lawsuits Report from Resource4thePeople: Federal Judge Schedules Important Status Conference
8. Medical Practice Management Important as Aging Baby Boomers and Affordable Care Act Expand Pool of Patients: Appointment-Plus
9. Jean LaMantia Registered Dietitian, Cancer Survivor and Author Announces An Important Partnership to Help Put a Much-Needed Resource Into the Hands of Cancer Patients Across the Nation
10. Researchers take important step in unlocking what causes congenital heart disease
11. Scott Tischler of Tischler Brothers Fitness unveils the 8 reasons why water is so important
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... Atlanta, GA (PRWEB) , ... December 07, 2016 , ... ... en route to respond to an emergency medical call when he lost control of ... injuries. After being extricated from his vehicle, he was transported to Atlanta Medical Center, ...
(Date:12/7/2016)... ... , ... Castle Dermatology Institute is now offering liquid facelifts with Sculptra ... to the face. Dr. Peyman Ghasri and Dr. Pedram Ghasri, San Fernando Valley ... rejuvenate and renew the facial appearance. , Sculptra is a highly effective injectable ...
(Date:12/7/2016)... ... 07, 2016 , ... Levels of a protein in the blood associated with ... online in the journal Radiology. , Heart disease and brain disease exact a major ... rapidly aging population. Damage to both organs often occurs at a subclinical stage, or ...
(Date:12/7/2016)... ... ... it came time to blow out his candles on his 14th birthday, Estefano Reano had ... team at Joe DiMaggio Children’s Hospital surprised his family with a phone call that ... , “He was playing at home, when we got the phone call telling us ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... from offices located in South Lyon, Dewitt, Williamston, East Lansing, Ann Arbor, and ... who needs treatment for a brain tumor. , Jason Bauer and his family ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... MOINES, Iowa , Dec. 8, 2016 /PRNewswire/ ... a pharmaceutical company advancing technologies designed to address ... appointment of Chitra Edwin , Ph.D., RAC, ... Compliance. Dr. Edwin will provide leadership for all ... for regulatory approvals, preparation of regulatory submissions, serving ...
(Date:12/7/2016)... 7, 2016 KEY FINDINGS ... such as reducing loss of blood during surgeries, ... arrests, rapid recovery after surgeries, and decreasing risks ... segmented into convective warming system, surface warming systems, ... reduce the stay at hospitals thus, lowering the ...
(Date:12/7/2016)... , Dec 7, 2016 Research and Markets ... and End User - Global Forecast to 2021" report to their ... , , ... 2.12 Billion by 2021, growing at a CAGR of 7.3% during the ... the growing prevalence of cancer and rapidly increasing geriatric population across the ...
Breaking Medicine Technology: