Navigation Links
An important discovery at the Montreal Heart Institute: A new approach to treat the most common heart valve disease in Western countries
Date:7/18/2013

Montreal, Canada, July 18, 2013 A study conducted by the team of Dr. Jean-Claude Tardif, Director of the Research Centre at the Montreal Heart Institute (MHI), has led to the discovery of a new approach to treat aortic valve stenosis through the administration of a compound that prevents valve deterioration and can even reverse the progression of the disease. A condition that is characterized by a narrowing of the aortic valve and that affects approximately 150,000 Canadians , aortic valve stenosis is the most common type of heart valve disease in Western countries. The results of this study were published in the British Journal of Pharmacology on July 15, 2013.

This study conducted in mice suffering from aortic valve stenosis showed successful outcomes with infusions of a compound that mimics HDL (high-density lipoprotein), which is often referred to as "good cholesterol." This treatment could help open narrowed aortic valves, avoid the major complications of aortic valve stenosis (including the need for heart surgery), and prevent heart failure and sudden death.

A less invasive option

"These results are extremely encouraging, as they allow us to hope that this type of treatment will work for people who suffer from aortic valve stenosis. If so, it will represent a brand-new treatment option that may even prevent open-heart surgery to replace valves damaged by stenosis," said Dr. Jean-Claude Tardif. "This treatment may be an alternative to a procedure that is complex, risky and very invasive for patients." Valve replacement surgery is currently the primary treatment option for this condition, with 13,000 surgeries conducted on average each year in Canada .

A growing incidence

Especially common in people over the age of 65, aortic valve stenosis can also affect people who are overweight, eat a high-fat diet, are diabetic or have a congenital abnormality. "In light of the aging of the population and alarming data on excess weight, diabetes, lifestyle and the diet of the population in general, this disease represents a major public health problem," stressed Dr. Tardif.

More details about the MHI study

In this study, mice were put on a cholesterol-enriched diet until aortic valve stenosis was detected using echocardiography (a medical imaging ultrasound system used in humans). The animals were then divided into two groups: a control group that received saline infusions and a treatment group that received infusions of a compound that mimics good cholesterol (an apoA-I mimetic peptide) for two weeks.

These results were particularly impressive as, after only 28 days of treatment, the aortic valve opened more fully in the treatment group compared to the control group. The aortic wall in the treatment group had also reduced in thickness compared to the control group.

Furthermore, microscopic analysis also revealed that the extent of the scar lesions (or accumulated collagen) in the valves was significantly smaller in the treated subjects than in the control subjects.


'/>"/>

Contact: Lauren Guay
lauren.guay@edelman.com
514-315-1970
Montreal Heart Institute
Source:Eurekalert

Related medicine news :

1. US Drug Watchdog Now Calls Their DePuy Pinnacle Hip Implant Blood Test Initiative Vital And They Urge Recipients To Call Them For Instructions About This Important Test
2. New Mirena IUD Complications Lawsuits Allegations Report: Resource4thePeople Reports Important Multidistrict Litigation Hearing Scheduled
3. Neurosurgery publishes findings of 3 important studies in June issue
4. Dr. Kanani, Woodland Hills Dentist: Tongue Brushing May Be as Important as Tooth Brushing
5. Latest Pradaxa Internal Bleeding Problem Allegation Lawsuits Update; Resource4thePeople Reports Judge Schedules Important Hearing
6. Alleged NuvaRing Blood-Clotting Lawsuits Update: Resource4thePeople Reports Important Hearing Scheduled for July
7. Alleged Zoloft Birth Defects Lawsuits Report from Resource4thePeople: Federal Judge Schedules Important Status Conference
8. Medical Practice Management Important as Aging Baby Boomers and Affordable Care Act Expand Pool of Patients: Appointment-Plus
9. Jean LaMantia Registered Dietitian, Cancer Survivor and Author Announces An Important Partnership to Help Put a Much-Needed Resource Into the Hands of Cancer Patients Across the Nation
10. Researchers take important step in unlocking what causes congenital heart disease
11. Scott Tischler of Tischler Brothers Fitness unveils the 8 reasons why water is so important
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ... , "Film editors can give their videos a whole new perspective by using the ... CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets ...
(Date:6/26/2016)... Clarkston, Michigan (PRWEB) , ... June 26, 2016 ... ... respect to fertility once they have been diagnosed with endometriosis. These women need ... but they also require a comprehensive approach that can help for preservation of ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 ... brings up a new, often overlooked aspect of head lice: the parasite’s ability to live ... not a common occurrence, but a necessary one in the event that lice have simply ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from PsychTests.com reveals that behind ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), ... company,s second affiliate in Latin America . ... ... Colombia ... ...
Breaking Medicine Technology: