Navigation Links
An important breakthrough in immunology by IRCM researchers
Date:6/7/2012

A team of researchers at the IRCM led by Dr. Andr Veillette made an important breakthrough in the field of immunology, which will be published online today by the scientific journal Immunity. The scientists explained a poorly understood molecular mechanism associated with a human immune disorder known as XLP disease or Duncan's syndrome.

"We studied the SAP molecule, which plays a critical role in multiple different types of immune cells," says Dr. Veillette, Director of the Molecular Oncology research unit at the IRCM. "More specifically, we wanted to understand why SAP is an essential component of natural killer cells' ability to eliminate abnormal blood cells."

Natural killer (NK) cells are crucial to the immune system, and provide rapid responses against cancer and virus-infected cells, especially blood cells as can be found in leukemia and lymphomas. Patients with XLP are at a high risk of developing lymphomas.

"Until now, the way by which SAP enhances NK cells' response to abnormal blood cells was not well understood," explains Zhongjun Dong, former researcher in Dr. Veillette's laboratory and first author of the article. "We discovered that SAP stimulates the function of NK cells through a double mechanism. On one hand, it couples the necessary genes and enzymes to increase NK cell responses, and on the other hand, it prevents genes from inhibiting these responses." Dr. Dong is now a professor at Tsinghua University, a leading university in China.

"The SAP molecule is important in immunity, as it is associated with most cases of XLP disease," adds Dr. Veillette. "In addition, our findings may have implications on the role of SAP in other diseases such as lupus and arthritis."

According to the XLP Research Trust, X-linked lymphoproliferative disease (XLP), also known as Duncan's syndrome, is a fatal disease affecting boys worldwide. The cause of the condition was only found in 1998, so many cases may no
'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Higher hospital volume more important than surgeon experience in outcome of prostate cancer surgery
2. Joslin scientists identify important mechanism that affects the aging process
3. Moffitt Cancer Center researchers: Quality of life as important as quantity of life
4. Timing pregnancy an important health concern for women
5. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
6. Bascom Palmer Eye Institute announces breakthrough for degenerative vision disorder
7. Mount Sinai researchers develop a multi-target approach to treating tumors
8. Doubling down on heart failure: Researchers discover new route to disease, and drugs to match
9. Researchers at IRB Barcelona uncover new clues about the origin of cancer
10. HIV drug may slow down metastatic breast cancer, say researchers at Jeffersons Kimmel Cancer Center
11. Student researchers seek to develop new therapies for cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... May 22, 2013 Unknown to the citizens ... at 30 mph. Minutes before it struck, the city’s ... nearing threat. This gave them time to reach safety and ... is proud to provide a product that will increase ... Wheelock SAFEPATH® SP40S Emergency Evacuation System provides employees ...
(Date:5/22/2013)... May 22 (HealthDay News) -- In the aftermath of this ... struggling to care for children and relatives, but also their ... during a natural disaster and relocating to temporary housing can ... offering a few tips on how to ease that transition. ... with your pet that can be used to help identify ...
(Date:5/22/2013)... at Massachusetts General Hospital (MGH) one of the ... half rated the training they had received in addiction ... Significant numbers felt unprepared to diagnose or treat such ... response to the findings, recently published online in the ... residents, training in addiction medicine. , "Our residents ...
(Date:5/22/2013)... study suggests that disturbed sleep in adolescents is ... uncertainly about future success. However, perceived support ... have a protective effect. , Results show ... mood and greater uncertainty about future success. Higher ... teachers were associated with significantly fewer sleep disruptions ...
(Date:5/22/2013)... The newest member of TeethWhiteningforFree.com is ... of Alabama graduate, Dr. Sanderson provides professional dental care ... dentist, he extends complimentary teeth whitening to his patients ... check up. Only a dental professional can decide if ... treatments. , Teeth whitening is an easy ...
Breaking Medicine News(10 mins):Health News:Telcom & Data Introduces Wheelock SAFEPATH® SP40S Emergency Evacuation System, An Effective Office Tool to Protect Employees from Severe Weather Threats 2Health News:Simple Steps Can Protect Pets in Weather Disasters 2Health News:Survey points out deficiencies in addictions training for medical residents 2Health News:Survey points out deficiencies in addictions training for medical residents 3Health News:Survey points out deficiencies in addictions training for medical residents 4Health News:Parent and teacher support protects teens from sleep problems and depression 2Health News:Dr. James Sanderson, Jr. Of SanDentistry in Hoover, Alabama Joins the TeethWhiteningforFree.com Family 2
... CBaySystems named to Deloitte,s Technology Fast 50 List for Maryland for a ... ... companies., ANNAPOLIS, Md., Oct. 8 CBaySystems ... prestigious,Technology Fast 50 Program for Maryland, a ranking of the 50 fastest,growing ...
... women more frequently take more of the life-prolonging supplemental ... women. , African-Americans whose cancer had spread to ... cancer therapy than white women, the study showed. Adjuvant ... in addition to the primary therapy. Studies suggest adjuvant ...
... Men From 46 States and 7 ... ... this,weekend,s fifth annual Avon Walk for Breast Cancer New York raised $10.2,million ... At,today,s Closing Ceremony at Hudson River Park,s Pier 84, Avon Foundation,Executive Director ...
... fall, study finds , SUNDAY, Oct. 7 (HealthDay News) -- ... have a better chance of survival than those diagnosed in ... suggests. , "Summer and autumn months correspond to times when ... not prove vitamin D is the determining factor, it does ...
... fibrosis is linked to MRI exposure, scientists say , ... with a newly identified disease called nephrogenic systemic fibrosis ... report. , The researchers also concluded that exposure to ... a significant risk factor for developing NSF, a painful ...
... SACRAMENTO, Calif., Oct. 5 Several medical groups,affiliated ... as tops in,quality by the independent and highly ... (IHA). The recognition is part,of the IHA,s annual ... medical groups recognized for top performance are,Solano Regional ...
Cached Medicine News:Health News:CBaySystems Selected to Receive Deloitte's 2007 Maryland Technology Fast 50 Award 2Health News:CBaySystems Selected to Receive Deloitte's 2007 Maryland Technology Fast 50 Award 3Health News:Whites take supplemental breast cancer therapy more often than blacks 2Health News:Fifth Annual Avon Walk for Breast Cancer New York Raises $10.2 Million 2Health News:Fifth Annual Avon Walk for Breast Cancer New York Raises $10.2 Million 3Health News:Prostate Cancer Survival Varies by Season 2Health News:New Kidney Disease Can Be Fatal 2Health News:Sutter Health Medical Groups Among the Best for Health Care Quality 2
(Date:5/22/2013)... MUNICH , May 22, 2013 JenaValve ... transcatheter aortic valve implantation (TAVI) systems for the treatment of ... the J enaValve Eval U ation of Long Term ... ients with S E vere Ao R tic Stenosis (JUPITER) ... is a post-market registry to evaluate five-year long term safety ...
(Date:5/22/2013)... , May 22, 2013 The new ... safe as the previous version used prior to 2010, ... Kaiser Permanente study published today in Vaccine. ... use beginning in 2010 after a series of trials. ... broader range of pneumococcal types than the previously used ...
(Date:5/22/2013)... Jersey , 22. Mai 2013 /PRNewswire/ ... Fähigkeitsentwicklung und Beratung, gab heute bekannt, dass ... Chris Geraghty , zum Hauptgeschäftsführer ernannt ... Jahre im Industriebereich wo er zahlreiche Führungspositionen ... von Ray Baxter an, der als Kepner-Tregoe ...
Breaking Medicine Technology:First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 2First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 3First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 4Kaiser Permanente Study Finds New Pneumococcal Vaccine Appears to be as Safe as Previously Used Vaccine 2Kaiser Permanente Study Finds New Pneumococcal Vaccine Appears to be as Safe as Previously Used Vaccine 3Kaiser Permanente Study Finds New Pneumococcal Vaccine Appears to be as Safe as Previously Used Vaccine 4Kepner-Tregoe, Inc. befördert Chris Geraghty zum Hauptgeschäftsführer 2Kepner-Tregoe, Inc. befördert Chris Geraghty zum Hauptgeschäftsführer 3
... Feb. 2 The Robert C. Gallo Foundation ... appointment of Franco Nuschese as director of international ... his colleagues, who are internationally known for expertise ... also supports other organizations producing groundbreaking HIV research."It ...
... (NYSE: KR ) said today it is recalling ... in its family of stores because the products have the ... names in the 31 states where Kroger operates are included ... Less, Fry,s, King Soopers, Smith,s, Dillons, QFC, City Market, Foods ...
Cached Medicine Technology:Franco Nuschese Tapped by Robert C. Gallo Foundation for AIDS and Virus Research 2Kroger Recalls Peanut Butter Bakery Cookies and Select Cakes Due to Possible Health Risk 2Kroger Recalls Peanut Butter Bakery Cookies and Select Cakes Due to Possible Health Risk 3
... the highest g-force ever. But optimal productivity ... Optima MAX combines maximum force, capacity, and ... that's worlds apart from any other system. ... enhanced efficiency, Optima takes productivity to the ...
... generating 694,000 x g at ... Beckman Coulter's Optima L-90K Ultracentrifuge ... separations in less time. This ... a broad range of superb ...
... With the ability to provide a simple, ... in lipemic samples), the Airfuge CLS delivers ... can be cleaned in 10 minutes, eliminating ... tabletop centrifuge: Reaches top speed in as ...
The Dimension RxL Max is an integrated chemistry system and is the most powerful and technologically advanced Dimension analyze with new standard for excellence in clinical diagnostics. Simply put, t...
Medicine Products: