Navigation Links
An important breakthrough at the IRCM associated with osteoporosis
Date:10/4/2011

Montral, October 4, 2011 Researchers at the Institut de recherches cliniques de Montral (IRCM), directed by Dr. Jean Vacher, identified a new gene that modulates bone mass and that could become a risk factor for developing osteoporosis. This scientific breakthrough will be published tomorrow in the scientific journal Cell Metabolism.

Osteoporosis is a "silent" genetic disease characterized by low bone mineral density and deterioration of bone tissue, which leads to increased bone fragility and risk of fracture. In all cases, the disease is caused by an imbalance between the formation and resorption of bone tissue.

"The overall objective of our research is to understand the molecular and cellular mechanisms that determine the balance between bone formation and resorption (breakdown)," explains Dr. Vacher, Director of the Cellular Interactions and Development research unit at the IRCM. "Osteoblasts are responsible for making bones and work in synergy with osteoclasts, which reshape the bone. To gain insight into these complex mechanisms, we are studying the role of new genes that influence osteoclasts and osteoblasts."

The team of researchers recently isolated a gene that modulates osteoclasts. They found, in mice, that a loss of this gene's function leads to a significant increase in the number of osteoclasts, thereby generating an even higher level of bone resorption.

"We identified this gene as a novel modulator of bone mineral density in mice and humans," adds Dr. Vacher. "More importantly, we showed that the human gene could represent a new susceptibility factor for osteoporosis. Hence, this discovery will help identify individuals with a greater predisposition to the disease who could benefit from preventive measures."

According to Osteoporosis Canada, as many as two million Canadians suffer from osteoporosis. One in four women over the age of 50 has osteoporosis, and so does one in eight men over the
'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Launch of On Time Air Filters: Home Air Filter Delivery Service Helps Homeowners Replace All-Important Home HVAC Filters On Time
2. Mayo Clinic researchers find oncogene is important in pancreatic cancer growth and spread
3. NORD Calls FDA Action An Important Advance for Patients
4. Galfand Berger Wins Important Case for Injured Workers in Pennsylvania
5. Author Proves What Celebrities are Learning in "Who Do You Think You Are?" is More Important Than They Realize
6. Frances national program to reduce HAIs reports important successes; uses mandatory reporting
7. A Monumentally Important Victory for Our Country
8. Recurrence of breast cancer after more than 10 years is an important indicator of survival
9. VA Proposes Important Amendment to Expand Healthcare for Veterans
10. Teaching medicine series covers the most important topics in medical education
11. LocumTenens.com Offers Important Tax Tips for 1099 Workers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... 31, 2014 In its latest blog post, ... believes that having family close by during a stay in ... the process is successful, is looking at 10 tips to ... , “Addiction recovery is a lifelong process, and one that ... committed to without compromise,” commented Best Drug Rehabilitation’s CEO ...
(Date:7/31/2014)... The study, The Truth Behind ... episode of care payments for four clinical areas—congestive heart ... replacements (hips and knees). Using the definition of ... Care Improvement program, the study examines these clinical areas ... the country. , “Our study reaffirms that, in most ...
(Date:7/30/2014)... 30, 2014 The Mesothelioma ... Penn's Abramson Cancer Center, will host a regional ... experts in the field of mesothelioma. September 26 marks ... is open to the public, and specifically aimed at ... who have been exposed to asbestos. , The conference ...
(Date:7/30/2014)... returning National Guard soldiers were more likely to ... life setbacks, including job loss, legal problems, divorce, ... military families. Results of the study by researchers ... are published online in the American Journal ... a major concern for reservists returning home. Nearly ...
(Date:7/30/2014)... (PRWEB) July 31, 2014 “United States Orthopedic ... data on the United States Orthopedic Braces and Supports market. ... volume (in units) and average price data (in US dollars), ... Supports , Ankle Braces and Supports , ... Braces and Supports. , Orthotics is a specialty ...
Breaking Medicine News(10 mins):Health News:New Best Drug Rehabilitation Blog Posts Looks at 10 Tips for Coping After Drug or Alcohol Rehab 2Health News:Recent Research Finds a New Driver of Cost Variation in Episode Payments 2Health News:Recent Research Finds a New Driver of Cost Variation in Episode Payments 3Health News:September Events: Regional Conference on Mesothelioma in Philadelphia 2Health News:September Events: Regional Conference on Mesothelioma in Philadelphia 3Health News:Vets' alcohol problems linked to stress on the home front 2Health News:US Orthopedic Braces and Supports Market (Knee, Ankle & Spinal) to 2020 Report Available at MarketOptimizer.org 2Health News:US Orthopedic Braces and Supports Market (Knee, Ankle & Spinal) to 2020 Report Available at MarketOptimizer.org 3Health News:US Orthopedic Braces and Supports Market (Knee, Ankle & Spinal) to 2020 Report Available at MarketOptimizer.org 4
... released figures which show that there is an incredible ... for rehabilitation treatment programs under the banner of NHS(National ... . ,Most of the centers earmarked for drug ... the in- patient wards are empty and that referral ...
... floor spasm and pain, which may now be relieved by ... symptoms of this condition are heaviness, frequency or urgency in ... Abbott of the Royal Hospital For Women, Randwick conducted a ... effect of botox on women with pelvic spasms.30 women were ...
... Carnegie Mellon University conducted a path breaking study on ... in their ability to differentiate between living and non ... The paper which can be found in the Journal ... to one of the intriguing traits of autism: the ...
... The American College of Surgeons (ACS) has accredited NewYork-Presbyterian ... with the highest possible designation (1A),// in recognition of ... available. The top-level designation is a first for New ... ,An estimated 30 percent of U.S. adults 20 years ...
... a major recent countrywide study, antipsychotic drugs that are ... in treating Alzheimer's disease as most of the patients ... ,This study was conducted by Lon Schneider, professor ... the Keck School of Medicine of the University of ...
... develop pneumococcal pneumonia -- a common bacterial pneumonia that ... October issue of Mayo Clinic Women's HealthSource is spreading ... //against this form of pneumonia and reduces the serious ... unaware of the vaccine, or may not know that ...
Cached Medicine News:Health News:NHS De-addiction, Rehabilitation waiting time ticking into months 2Health News:Autistic Children May Lag behind in ‘Categorization of Objects 2Health News:NewYork-Presbyterian Receives Highest Accreditation for Bariatric Surgery 2
(Date:7/30/2014)... LAKE, N.J. and SAN DIEGO ... Inc. (NASDAQ: ARNA ) announced today that an ... 3 trials of lorcaserin entitled, "Early Weight Loss While on ... Weight-Loss Outcomes," was recently published in the online issue of ... Obesity Society. The objective of these analyses was to identify ...
(Date:7/30/2014)... DALLAS , July 30, 2014 /PRNewswire-iReach/ -- ... on Global and Chinese Heparin sodium (CAS 9041-08-1) ... reviews the basic information of Heparin sodium (CAS ... application and manufacturing technology. The report then explores ... (CAS 9041-08-1) & calcium (CAS 37270-89-6) listing their ...
(Date:7/30/2014)...   Epic Sciences, Inc. ("Epic"), a ... novel diagnostics to personalize and advance the treatment ... of a $30 million Series C Preferred Stock ... and Arcus Ventures, existing investors Domain Associates, Roche ... as undisclosed individual investors. With the proceeds of ...
Breaking Medicine Technology:Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 2Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 3Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 4Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 5Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 6Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 7Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 2Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 3Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 4Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 5Epic Sciences Announces Series C Financing to Advance Essential Cancer Diagnostics for Personalized Medicine 2Epic Sciences Announces Series C Financing to Advance Essential Cancer Diagnostics for Personalized Medicine 3
... NASHVILLE, Tenn., May 11, 2011 Cumberland Pharmaceuticals ... pharmaceutical company focused on hospital acute care and gastroenterology ... overview at the 2011 UBS Global Specialty Pharmaceuticals Conference ... p.m. The presentation will be simultaneously ...
... S.C., May 11, 2011 /PRNewswire-USNewswire/ -- ... announced that two client companies received big check investment ... Therapeutics and EnviroMix, both technology-based start-ups located in the ... technology and business model. Madeira Therapeutics was ...
Cached Medicine Technology:SC Launch Presents "Big Check" Investment to Two South Carolina Companies 2SC Launch Presents "Big Check" Investment to Two South Carolina Companies 3
Desmarres Lid Retractor thin solid blades. Size 2....
... system introduces a new level ... microsurgical instrumentation. It has an ... with advanced microcomputer control of ... operate with a full range ...
Multiple Modulation Phaco (MMP) programmability with eight surgeon settings for maximum versatility. The combination of the peristaltic power balanced pump and the piezoelectric handpiece results in ...
... is a unique combination of Paradigm's ... flexibility for modular hardware modifications and ... of changing cataract surgical techniques and ... ophthalmic surgical platforms providing open architecture ...
Medicine Products: