Navigation Links
An effective strategy for inhibition of cirrhosis

In China, the incidence of liver cirrhosis is still high, although new therapeutic approaches have recently been proposed, there is no established therapy for liver fibrosis, and Authors investigated the prevention effects of Chinese Medicine Qianggan-Rongxian Soup on liver fibrosis induced by DMN in rat. Chinese Medicin Qianggan-Rongxian decoction can inhibit hepatic fibrosis resulted from chronic liver injure, retard the development of cirrhosis, and notably ameliorate the liver function. It may be a safe and effective therapeutic drug for patients with fibrosis.

A research article to be published on 14 June 2008, in the World Journal of Gastroenterology addresses this question. The research team led by Chun-Hui Li from affiliated Hospital of Chengde Medicine College studied the inhibitory effect of Huangqi Zhechong decoction on liver fibrosis in rat.

Qianggan-Rongxian decoction, especially the medium-dose administration could decrease the area-density percentage of collagen fibrosis. HA, LN, and type IV collagen are good serum markers of hepatic fibrosis. In this study, the serum contents of these 3 markers in the model group were much higher than those of the controls. And the Qianggan-Rongxian decoction groups had significantly low HA, LN, and type IV collagen levels in serum than those in the controls, ALT and AST are indexes to describe liver functions. Most part of ALT is presented in the cytoplasm of liver cell, discharged in blood when degeneration, hyper permeability and necrosis of liver cells occur. So the increase of ALT level in serum reflects the degree of liver cell injury. Our study showed that the Qianggan-Rongxian decoction could decrease serum levels of ALT and AST in rats with hepatic injury caused by DMN. It indicates that Qianggan-Rongxian decoction may work through protecting the liver cells, which indicated that Qianggan-Rongxian decoction could successfully prevent hepatic fibrosis.

The mechanism of DMN-induced liver fibrosis has been shown to be associated with immune function, which is similar to the mechanism of human liver fibrosis. Thus, DMN-induced rat liver fibrosis may be a useful model for determination of liver fibrosis during drug screenin. The mechanism of the Qianggan-Rongxian decoction may need further research.

This study may provide a safe and effective strategy for inhibition of cirrhosis in clinic use.


Contact: Lai-Fu Li
World Journal of Gastroenterology

Related medicine news :

1. New treatment effective in counteracting cocaine-induced symptoms
2. Use of certain lipid measures not more effective in predicting coronary heart disease
3. HPV vaccine does not appear to be effective for treating pre-existing HPV infection
4. Effectiveness of mouse breeds that mimic Alzheimers disease symptoms questioned
5. Stanford study highlights cost-effective method of lowering heart disease risks
6. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
7. Case Management Cost-Effective Way to Cut Heart Risks
8. ResMed Names Kieran Gallahue as Chief Executive Officer, Effective January 1, 2008.
9. Nasal Anthrax Vaccine Proves Effective in Animal Study
10. Family-based treatment more effective than supportive psychotherapy in treating bulimia
11. Consumer Reports Analysis: Drugs for Nerve Pain, Fibromyalgia Effective, But Not Always Best
Post Your Comments:
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... for mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... solutions to the network of the Tennessee Counseling Association, adding exclusive benefits and ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A ... 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the ... history as home to some of the world’s leading providers of cereal and other ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced ... feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as a ... has released tools for healthy coping following a traumatic event. , Trauma sufferers tend ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Story Highlights: ... the health care industry is causing providers to review ... Deloitte offers a suite of solutions for health care ... cost optimization: labor resource analysis, revenue cycle optimization and ... outcomes and better economics ...
(Date:6/24/2016)... SOUTH SAN FRANCISCO, Calif. , June 24, ... GBT ), a biopharmaceutical company developing novel ... with significant unmet needs, today announced the closing ... 6,400,000 shares of common stock, at the public ... the shares in the offering were offered by ...
(Date:6/24/2016)... 24, 2016 Research and ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" report ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, ... Structural electronics involves electronic and/or electrical components ... replacing dumb structures such as vehicle bodies or ...
Breaking Medicine Technology: