Navigation Links
An effective strategy for inhibition of cirrhosis
Date:9/24/2008

In China, the incidence of liver cirrhosis is still high, although new therapeutic approaches have recently been proposed, there is no established therapy for liver fibrosis, and Authors investigated the prevention effects of Chinese Medicine Qianggan-Rongxian Soup on liver fibrosis induced by DMN in rat. Chinese Medicin Qianggan-Rongxian decoction can inhibit hepatic fibrosis resulted from chronic liver injure, retard the development of cirrhosis, and notably ameliorate the liver function. It may be a safe and effective therapeutic drug for patients with fibrosis.

A research article to be published on 14 June 2008, in the World Journal of Gastroenterology addresses this question. The research team led by Chun-Hui Li from affiliated Hospital of Chengde Medicine College studied the inhibitory effect of Huangqi Zhechong decoction on liver fibrosis in rat.

Qianggan-Rongxian decoction, especially the medium-dose administration could decrease the area-density percentage of collagen fibrosis. HA, LN, and type IV collagen are good serum markers of hepatic fibrosis. In this study, the serum contents of these 3 markers in the model group were much higher than those of the controls. And the Qianggan-Rongxian decoction groups had significantly low HA, LN, and type IV collagen levels in serum than those in the controls, ALT and AST are indexes to describe liver functions. Most part of ALT is presented in the cytoplasm of liver cell, discharged in blood when degeneration, hyper permeability and necrosis of liver cells occur. So the increase of ALT level in serum reflects the degree of liver cell injury. Our study showed that the Qianggan-Rongxian decoction could decrease serum levels of ALT and AST in rats with hepatic injury caused by DMN. It indicates that Qianggan-Rongxian decoction may work through protecting the liver cells, which indicated that Qianggan-Rongxian decoction could successfully prevent hepatic fibrosis.

The mechanism of DMN-induced liver fibrosis has been shown to be associated with immune function, which is similar to the mechanism of human liver fibrosis. Thus, DMN-induced rat liver fibrosis may be a useful model for determination of liver fibrosis during drug screenin. The mechanism of the Qianggan-Rongxian decoction may need further research.

This study may provide a safe and effective strategy for inhibition of cirrhosis in clinic use.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. New treatment effective in counteracting cocaine-induced symptoms
2. Use of certain lipid measures not more effective in predicting coronary heart disease
3. HPV vaccine does not appear to be effective for treating pre-existing HPV infection
4. Effectiveness of mouse breeds that mimic Alzheimers disease symptoms questioned
5. Stanford study highlights cost-effective method of lowering heart disease risks
6. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
7. Case Management Cost-Effective Way to Cut Heart Risks
8. ResMed Names Kieran Gallahue as Chief Executive Officer, Effective January 1, 2008.
9. Nasal Anthrax Vaccine Proves Effective in Animal Study
10. Family-based treatment more effective than supportive psychotherapy in treating bulimia
11. Consumer Reports Analysis: Drugs for Nerve Pain, Fibromyalgia Effective, But Not Always Best
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... February 11, 2016 , ... Pediatric cardiovascular surgeons, cardiologists and ... making data on heart procedures public and easily understandable for families and patients ... of Pediatric and Congenital Heart Disease Outcomes will bring hundreds of pediatric heart ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... seeking candidates for the Board of Commissioners. Individuals interested in volunteer board service ... with diversity of clinical practice settings and across allied health to contribute to ...
(Date:2/11/2016)... ... February 11, 2016 , ... Colorado spine surgeon, ... of 334 spine surgeons to know in 2016 . The list consists of ... of spine surgery. , Dr. Corenman understands the importance of clinical excellence; he ...
(Date:2/11/2016)... ... 2016 , ... The annual list showcases the 20 Most Promising SharePoint Solution ... dedication and commitment to the SharePoint ecosystem. A panel of experts and members of ... to recognize and promote technology entrepreneurship. , The survey was made at the ...
(Date:2/11/2016)... ... ... Husted Kicking has completed its Third Annual Husted Kicking College ... 2016 according to kicking coach Michael Husted. , “This event serves as an official ... Indianapolis,” says Husted. “The NFL uses a third party organization to select players for ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... -- --> --> Transparency ... titled "Sports Medicine Devices Market - Global Industry Analysis, Size, ... the report, the global sports medicine devices market is anticipated ... growing from a value of US$6.1 bn in 2012 to ... --> The global sports medicine devices market is fueled ...
(Date:2/11/2016)... , Feb. 11, 2016 PLAD, Inc. ... out 2016 with sales exceeding company targets, are adding ... received their trademark from the United States Patent and ... Clark , Chief Executive Officer of PLAD, Inc.  In ... Pennsylvania with two new customers, ...
(Date:2/11/2016)... , Feb. 11, 2016 Exactus ... company providing high-quality specialty pharmacy care for those ... today it has achieved full Specialty Pharmacy Accreditation ... organization dedicated to promoting health care quality through ... --> The URAC accreditation process ...
Breaking Medicine Technology: