Navigation Links
An adjuvant chemotherapeutic agent in gastric cancer therapy
Date:2/17/2009

Peritoneal carcinomatosis can be thought of as a series of events that together form a peritoneal metastatic cascade. The peritoneal stromal tissue appears to be a friendly host for tumour proliferation, providing a rich source of growth factors and chemokines known to be involved in tumour metastasis. Till now, our understanding of the molecular mediators that orchestrate this cascade is weakly understood. Astragalus memebranaceus,a traditional chinese herbal medicine used for the treatment of common cold , diarrhea, fatigue anorexia and cardiac diseases. In recent years, it has been proposed that Astragalus may possess anti-apoptosis potential in peritoneal mesothelial cell. In spite of this, the anti-apoptosis effects of Astragalus saponin extract in human peritoneal mesothelial cells during peritoneal carcinomatosishas has not been studied. In this study, the anti-apoptosis effects of Astragalus saponin extract were investigated in human peritoneal mesothelial cells during peritoneal gastric cancer metastasis.

A research article to be published on February 7, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Hui-Mian Xu from Department of Oncology, The First Affiliated Hospital, China Medical University.Human peritoneal mesothelial cell line HMrSV5 was co-incubated with gastric cancer cell supernatant and/or Astragalus injection. Morphological changes were observed. Apoptosis was determined by transmission electron microscope. Apoptosis was also quantified by two methods: the detection of acridine orange/ethidium bromide-stained condensed nuclei by fluorescent microscopy and flow cytometry. The expressions of Bcl-2 and Bax were evaluated by immunostaining.

After 24h of being treated with gastric cancer cell supernatant, mesothelial cells presented morphological changes, exfoliation happened and naked areas appeared.

Cell supernatant from gastric cancer cell MKN45 were effective in inducing apoptosis in mesothelial cells in a time-dependent manner. Obvious morphological changes of cell apoptosis were found. Astragalus injection could partly suppress these changes, as well as regulate the expressions of Bcl-2 and Bax in mesothelial cells. These findings demonstrated that gastric cancer cell could induce the apoptosis of human peritoneal mesothelial cell through its supernatant. Astragalus injection could inhibit this kind of phenomenon and therefore, might represent an adjuvant chemotherapeutic agent in gastric cancer therapy.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Nanoemulsion-Based Intranasal Influenza Vaccine Adjuvant Triggers Robust Immunity Using Significantly Less Antigen
2. Cancer patients who receive neoadjuvant therapy followed by mastectomy may not need radiation
3. Genomic Health Announces Oncotype DX(R) Provides Additional Prognostic Benefit in Patients Assessed With Adjuvant Online
4. Infectious Disease Research Institute Receives Grant from the Bill & Melinda Gates Foundation for Adjuvant Access and Development
5. A new chemotherapeutic target for hepatocellular carcinoma
6. Senior Market Sales Offers Discounted E&O Insurance for Agents
7. An Oral Agent for the Treatment of Moderate to Severe Psoriasis Would Earn a Higher Patient Share in the United States than in Europe
8. CRi to Distribute VisEn Medicals Portfolio of Fluorescence In Vivo Imaging Agents and Labels in North America
9. Rapid Generic Erosion of Branded Agents, Including Market-Leading Viagra, Will Cause Sales of Erectile Dysfunction Drugs to Remain Flat Over the Next Decade
10. RE/MAX Northern Illinois Real Estate Agents Raises $284,000 For CMN In 2008, An 18 Percent Increase Over Prior Year
11. Aflac Agents and Employees Boost Bone Marrow Registry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... , ... February 05, 2016 , ... US Sports ... Studio in Dover, NH to direct high-performance kids yoga training. ChildLight Yoga Studio is ... just one hour from Boston. , ChildLight Yoga Studio founder Lisa Flynn expresses her ...
(Date:2/5/2016)... ... February 05, 2016 , ... The American public tends ... water may be safer than regular municipal or well water. The recent experience with ... Sharon Kleyne, could go a long way toward increasing public acceptance of recycled waste ...
(Date:2/5/2016)... ... February 05, 2016 , ... Give To Cure ... to search for and donate to Give To Cure’s campaign that is crowdfunding clinical ... lets users make and share payments through a smart device. In 2015 alone, Venmo ...
(Date:2/5/2016)... ... February 05, 2016 , ... Pivot Point Consulting, a ... KLAS: Software & Services for HIT Implementation Support & Staffing report with an ... vendor performance by healthcare executives, managers and clinicians representing over 4,500 hospitals and ...
(Date:2/5/2016)... Georgia (PRWEB) , ... February 05, 2016 , ... Dr. ... to announce their 2nd Annual No Cost Dental Day to individuals in need. The ... The purpose of this No Cost Dental Day is to provide dental care to ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... LONDON , Feb. 4, 2016 ... Summary Global Markets Direct,s, ,Wegener Polyangiitis - ... the Wegener Polyangiitis,s therapeutic pipeline. This report ... Wegener Polyangiitis, complete with comparative analysis at various ... action (MoA), route of administration (RoA) and molecule ...
(Date:2/4/2016)... -- Summary Breast cancer, a malignant neoplasm, is ... cancer in women worldwide, accounting for 16% of all ... of women diagnosed with breast cancer has increased over ... has declined due to earlier diagnosis and better treatment ... the past four decades, especially with increasing usage of ...
(Date:2/4/2016)... 2016 Frontier Pharma: Chronic Obstructive Pulmonary ... Chronic Obstructive Pulmonary Disease (COPD) ... of the airways and lungs. Persistent breathing difficulties ... disease one of the leading causes of morbidity ... world. COPD is linked to cumulative exposure to ...
Breaking Medicine Technology: