Navigation Links
An adjuvant chemotherapeutic agent in gastric cancer therapy
Date:2/17/2009

Peritoneal carcinomatosis can be thought of as a series of events that together form a peritoneal metastatic cascade. The peritoneal stromal tissue appears to be a friendly host for tumour proliferation, providing a rich source of growth factors and chemokines known to be involved in tumour metastasis. Till now, our understanding of the molecular mediators that orchestrate this cascade is weakly understood. Astragalus memebranaceus,a traditional chinese herbal medicine used for the treatment of common cold , diarrhea, fatigue anorexia and cardiac diseases. In recent years, it has been proposed that Astragalus may possess anti-apoptosis potential in peritoneal mesothelial cell. In spite of this, the anti-apoptosis effects of Astragalus saponin extract in human peritoneal mesothelial cells during peritoneal carcinomatosishas has not been studied. In this study, the anti-apoptosis effects of Astragalus saponin extract were investigated in human peritoneal mesothelial cells during peritoneal gastric cancer metastasis.

A research article to be published on February 7, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Hui-Mian Xu from Department of Oncology, The First Affiliated Hospital, China Medical University.Human peritoneal mesothelial cell line HMrSV5 was co-incubated with gastric cancer cell supernatant and/or Astragalus injection. Morphological changes were observed. Apoptosis was determined by transmission electron microscope. Apoptosis was also quantified by two methods: the detection of acridine orange/ethidium bromide-stained condensed nuclei by fluorescent microscopy and flow cytometry. The expressions of Bcl-2 and Bax were evaluated by immunostaining.

After 24h of being treated with gastric cancer cell supernatant, mesothelial cells presented morphological changes, exfoliation happened and naked areas appeared.

Cell supernatant from gastric cancer cell MKN45 were effective in inducing apoptosis in mesothelial cells in a time-dependent manner. Obvious morphological changes of cell apoptosis were found. Astragalus injection could partly suppress these changes, as well as regulate the expressions of Bcl-2 and Bax in mesothelial cells. These findings demonstrated that gastric cancer cell could induce the apoptosis of human peritoneal mesothelial cell through its supernatant. Astragalus injection could inhibit this kind of phenomenon and therefore, might represent an adjuvant chemotherapeutic agent in gastric cancer therapy.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Nanoemulsion-Based Intranasal Influenza Vaccine Adjuvant Triggers Robust Immunity Using Significantly Less Antigen
2. Cancer patients who receive neoadjuvant therapy followed by mastectomy may not need radiation
3. Genomic Health Announces Oncotype DX(R) Provides Additional Prognostic Benefit in Patients Assessed With Adjuvant Online
4. Infectious Disease Research Institute Receives Grant from the Bill & Melinda Gates Foundation for Adjuvant Access and Development
5. A new chemotherapeutic target for hepatocellular carcinoma
6. Senior Market Sales Offers Discounted E&O Insurance for Agents
7. An Oral Agent for the Treatment of Moderate to Severe Psoriasis Would Earn a Higher Patient Share in the United States than in Europe
8. CRi to Distribute VisEn Medicals Portfolio of Fluorescence In Vivo Imaging Agents and Labels in North America
9. Rapid Generic Erosion of Branded Agents, Including Market-Leading Viagra, Will Cause Sales of Erectile Dysfunction Drugs to Remain Flat Over the Next Decade
10. RE/MAX Northern Illinois Real Estate Agents Raises $284,000 For CMN In 2008, An 18 Percent Increase Over Prior Year
11. Aflac Agents and Employees Boost Bone Marrow Registry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... , ... June 28, 2017 , ... ... is pleased to announce that a two year study conducted by the University ... Creek zeolite was successful in remediating potash brine-impacted groundwater. As a part of ...
(Date:6/28/2017)... VA (PRWEB) , ... June 28, 2017 , ... ... protection assistance and financial consultations to communities in northern Virginia and DC, is ... to help provide for patients with Alzheimer’s and other disorders that lead to ...
(Date:6/27/2017)... ... June 27, 2017 , ... Nearly 70 percent of ... released today by the American Society for Dermatologic Surgery (ASDS). , ... of consumers considering a cosmetic medical procedure has doubled since 2013. , “Cosmetic ...
(Date:6/27/2017)... ... June 27, 2017 , ... Salucro, the ... the health care industry’s hospitals and provider groups, has announced that it will ... customers. Parasail Health is a San Francisco health-finance startup that has launched a ...
(Date:6/27/2017)... ... ... From June 20-22, EarQ and Widex held an exclusive training ... EarQ is headquartered. , Together, the organizations educate hearing care professionals on how ... the latest in hearing technology. At the event, EarQ members got an in-depth ...
Breaking Medicine News(10 mins):
(Date:6/5/2017)... , June 5, 2017 Kohll,s Pharmacy ... the United States . The Raizer is ... a fallen person up to an almost-standing position ... and operated by one assistant and does not ... is simple enough that a child can operate it, ...
(Date:6/1/2017)... 2017 Nutriceutical Holdings (NH), parent company of ... and KD Pharma Group have decided to join forces ... Pharma Group. KD Pharma Group will become the largest ... the entire company. "We believe we have ... to growing the NH companies by providing us with ...
(Date:5/30/2017)... May 30, 2017 Therapix Biosciences Ltd. (Nasdaq: ... in the development of cannabinoid-based drugs, today announced ... overview at three upcoming scientific and investor conferences ... Micro Invitational: ... Date:                     Wednesday, ...
Breaking Medicine Technology: