Navigation Links
An adjuvant chemotherapeutic agent in gastric cancer therapy
Date:2/17/2009

Peritoneal carcinomatosis can be thought of as a series of events that together form a peritoneal metastatic cascade. The peritoneal stromal tissue appears to be a friendly host for tumour proliferation, providing a rich source of growth factors and chemokines known to be involved in tumour metastasis. Till now, our understanding of the molecular mediators that orchestrate this cascade is weakly understood. Astragalus memebranaceus,a traditional chinese herbal medicine used for the treatment of common cold , diarrhea, fatigue anorexia and cardiac diseases. In recent years, it has been proposed that Astragalus may possess anti-apoptosis potential in peritoneal mesothelial cell. In spite of this, the anti-apoptosis effects of Astragalus saponin extract in human peritoneal mesothelial cells during peritoneal carcinomatosishas has not been studied. In this study, the anti-apoptosis effects of Astragalus saponin extract were investigated in human peritoneal mesothelial cells during peritoneal gastric cancer metastasis.

A research article to be published on February 7, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Hui-Mian Xu from Department of Oncology, The First Affiliated Hospital, China Medical University.Human peritoneal mesothelial cell line HMrSV5 was co-incubated with gastric cancer cell supernatant and/or Astragalus injection. Morphological changes were observed. Apoptosis was determined by transmission electron microscope. Apoptosis was also quantified by two methods: the detection of acridine orange/ethidium bromide-stained condensed nuclei by fluorescent microscopy and flow cytometry. The expressions of Bcl-2 and Bax were evaluated by immunostaining.

After 24h of being treated with gastric cancer cell supernatant, mesothelial cells presented morphological changes, exfoliation happened and naked areas appeared.

Cell supernatant from gastric cancer cell MKN45 were effective in inducing apoptosis in mesothelial cells in a time-dependent manner. Obvious morphological changes of cell apoptosis were found. Astragalus injection could partly suppress these changes, as well as regulate the expressions of Bcl-2 and Bax in mesothelial cells. These findings demonstrated that gastric cancer cell could induce the apoptosis of human peritoneal mesothelial cell through its supernatant. Astragalus injection could inhibit this kind of phenomenon and therefore, might represent an adjuvant chemotherapeutic agent in gastric cancer therapy.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Nanoemulsion-Based Intranasal Influenza Vaccine Adjuvant Triggers Robust Immunity Using Significantly Less Antigen
2. Cancer patients who receive neoadjuvant therapy followed by mastectomy may not need radiation
3. Genomic Health Announces Oncotype DX(R) Provides Additional Prognostic Benefit in Patients Assessed With Adjuvant Online
4. Infectious Disease Research Institute Receives Grant from the Bill & Melinda Gates Foundation for Adjuvant Access and Development
5. A new chemotherapeutic target for hepatocellular carcinoma
6. Senior Market Sales Offers Discounted E&O Insurance for Agents
7. An Oral Agent for the Treatment of Moderate to Severe Psoriasis Would Earn a Higher Patient Share in the United States than in Europe
8. CRi to Distribute VisEn Medicals Portfolio of Fluorescence In Vivo Imaging Agents and Labels in North America
9. Rapid Generic Erosion of Branded Agents, Including Market-Leading Viagra, Will Cause Sales of Erectile Dysfunction Drugs to Remain Flat Over the Next Decade
10. RE/MAX Northern Illinois Real Estate Agents Raises $284,000 For CMN In 2008, An 18 Percent Increase Over Prior Year
11. Aflac Agents and Employees Boost Bone Marrow Registry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... 02, 2016 , ... Two years ago, Arizona State University ... live by 1 million viewers and won numerous honors, including the region’s top ... the Walter Cronkite School of Journalism and Mass Communication are following up their ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... the launch of its 60-day free trial program for all of the company’s ... the offer a truly hassle free experience. , FlexiSpot’s unique desktop risers use ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... of two ostomy patients, standing as living proof that attitude and determination can ... diseases and issues that spike around the holidays. This campaign will offer patients ...
(Date:12/2/2016)... ... December 02, 2016 , ... The PAINWeekEnd Regional Conference will ... Spa in Honolulu, offering local frontline clinicians the opportunity to extend their certified ... demand for supplemental training related to pain management has surged dramatically in recent ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... "Pro3rd Accents ... FCPX editors to create versatile lower third titles with just a few clicks of ... Accents Volume 2 includes 30 lower third animations. Choose from various styles with accented ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... ALEXANDRIA, Va. , Dec. 2, 2016 /PRNewswire-USNewswire/ ... year by the Academy of Managed Care Pharmacy ... care organizations can better address the opioid addiction ... Medication Assisted Therapies (MAT). ATAG,s newly ... in Improving Access to Naloxone," addresses many issues ...
(Date:12/2/2016)... 2016  Maxor National Pharmacy Services, LLC ("Maxor"), today announced ... ("PSI").  The combination of Texas -based Maxor ... PSI bring together both company,s clinical expertise and high-touch patient ... industry-leading specialty pharmacy. About Maxor ... , , ...
(Date:12/2/2016)... , Dec. 2, 2016 CVS Health Corporation ... Analyst Day in New York City on Thursday, December 15, 2016, beginning ... leadership team will provide an in-depth review of the ... value. The company will also discuss 2017 earnings guidance ... webcast of the event will be broadcast simultaneously on ...
Breaking Medicine Technology: