Navigation Links
An Oral Approach to Heart Disease
Date:9/11/2008

Researchers study interaction of mouth bacteria and blood cells

THURSDAY, Sept. 11 (HealthDay News) -- Irish researchers are trying to develop a new way of attacking heart disease -- through the mouth.

"We are trying to understand the mechanisms by which oral bacteria colonies can lead to cardiovascular disease," said Steve Kerrigan of the Royal College of Surgeons in Dublin, and the principal investigator in a group that will report on the effort Thursday at the Society for General Microbiology meeting in Dublin.

People with poor dental hygiene, especially those with bleeding gums, are prey to more than 700 different types of oral bacteria, Kerrigan noted. "When those bacteria get into the bloodstream, they interact with platelets, the blood cells that can clump. The bacteria can cause them to clump together to form clots that can partially block blood vessels," he said.

Kerrigan and his colleagues, including Dr. Howard F. Jenkinson of the University of Bristol, have been investigating the cell surface proteins that allow bacteria to interact with cell platelets.

"We are trying to find new drugs that prevent this interaction," Kerrigan said. "The treatment now for this condition is aggressive antibiotic treatment. With all the controversy about antibiotic-resistant bacteria that is emerging, it would be best not to use antibiotics. If we find the ways the bacteria are causing the platelets to clump, it would be a new treatment target."

Analysis of the genes of streptococci often found in the mouth has identified a number of proteins responsible for the adherence of bacteria to platelets, Kerrigan said. "We have a few targets that we are researching just now," he said. "We have some good leads at the moment, and are trying to refine what we have found."

While "there is no definitive study that shows a cause-and-effect relationship between periodontal disease and heart disease," said Sally Cram, a Washington, D.C. periodontist who is a consumer adviser to the American Dental Association, "we have a number of studies coming out that indicate a strong relationship between infection in the mouth and gums and other things in your health, such as diabetes and heart disease."

Even although the case may not be completely proven, she added, "I tell my patients that, given that periodontal disease is preventable by doing certain things that take five minutes a day, it is worth doing those things."

Cram's recommendations are standard: brush twice a day, floss once a day, see a dentist regularly or when signs of trouble appear.

"Especially if there is a family history of heart disease or diabetes, it makes common sense to help prevent gum disease," she said.

Good oral hygiene is a necessity because bacteria easily get into the bloodstream from the mouth, from routine activities such as chewing and from tooth brushing, said Peter Lockhart, chairman of the department of oral medicine at the Carolinas Medical Center, in Charlotte, N.C.

Earlier this year, Lockhart published a study of 290 dental patients showing that bacteria could be detected in 23 percent of them after tooth brushing, compared to 30 percent when a tooth was pulled after the patient took an antibiotic and 60 percent when no antibiotic was taken.

So oral hygiene is "a much more appropriate focus for prevention of endocarditis," infection of the lining of the heart or a heart valve, Lockhart said.

More information

Learn about periodontal disease and its prevention from the American Dental Association.



SOURCES: Steve Kerrigan, Ph.D., principal investigator, Royal College of Surgeons, Dublin; Sally Cram, D.D.S., periodontist, Washington D.C.; Peter Lockhart, chairman, oral medicine, Carolinas Medical Center, Charlotte, N.C; Sept. 10, 2008, presentation, Society for General Microbiology, Dublin, Ireland


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. A potential approach to treatment of hepatitis B virus infection
2. New approach, old drug show promise against hepatitis C, Stanford research shows
3. Ingenious Med Continues Record Customer Growth and Approaches Key Milestones
4. New approach to cancer: Find most tightly controlled genes
5. New approach sheds light on ways Circadian disruption affects human health
6. Kognitio CEO Offers Outsourced, Service-Based Data Warehousing as a New Approach to Large Scale Analytics
7. First steps towards a new approach to epilepsy treatment
8. Non-Surgical Approach Can Treat Lung Cancers
9. Weizmann Institute scientists develop a new approach to treating autoimmune disease
10. New vaccine approach prevents/reverses diabetes in lab study at Childrens Hospital of Pittsburgh
11. NIAID to advance B-cell approach to HIV vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
An Oral Approach to Heart Disease 
(Date:12/2/2016)... ... December 02, 2016 , ... Advanced Inc., a leading provider of travel therapy ... MBA to serve as Advanced Inc.’s Chief Financial Officer, effective December 1, 2016. Jason ... extensive financial and operational leadership experience to Advanced Inc. He began his career in ...
(Date:12/2/2016)... ... 2016 , ... Center for Autism and Related Disorders (CARD) Portland today announced ... disorder (ASD) and other developmental disabilities. The group, which is being launched with the ... the opportunity to share stories and advice, seek help, and continue their education on ...
(Date:12/2/2016)... ... 02, 2016 , ... U.S. Surgeon General, Dr. Vivek Murthy, graces the cover ... he was inspired to practice medicine at an early age by his father, who ... making diagnoses and prescribing medicine,” he states. “It is about building relationships with people; ...
(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet’s newest ... patients, standing as living proof that attitude and determination can combine into the ... that spike around the holidays. This campaign will offer patients a new-found hope, ...
(Date:12/2/2016)... ... December 02, 2016 , ... More than half of American teens report ... parents report speaking with their child about sex related topics, less than 60 percent ... is proud to announce the launch of its second edition of the “Sexual Wellness” ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... DUBLIN , Dec 2, 2016 Research ... Market Size, Share, Development, Growth and Demand Forecast to 2022" report ... , , ... revenue of $6 billion in 2015, and it is expected to grow ... ultrasound segment is expected to witness faster growth during the forecast period, ...
(Date:12/2/2016)... December 2, 2016 On Thursday, ... honored excellence in research, development and innovation in the ... dinner was held in the presence of Sergey Tsyb, ... Russian Federation , Natalia Sanina, First Vice ... Murashko , Head of Roszdravnadzor, National Service of Control ...
(Date:12/2/2016)... 2, 2016 CVS Health Corporation (NYSE: ... in New York City on Thursday, December 15, 2016, beginning at 8:00 a.m. ... will provide an in-depth review of the company,s strategies ... company will also discuss 2017 earnings guidance during the ... the event will be broadcast simultaneously on the Investor ...
Breaking Medicine Technology: