Navigation Links
An Alternative to Medicinal Marijuana
Date:4/27/2008

Nerve agents stimulated cannabinoid receptors in mice, offering pain relief without side effects

SUNDAY, April 27 (HealthDay News) -- Scientists think they may have found a way to harness marijuana's medicinal powers without unleashing the plant's memory-robbing properties.

But a new and improved dope-based medication is unlikely to hit doctors' offices near you soon.

"This has great potential but it's years away from human application," said one expert, Dr. Dennis J. Patin, associate professor of clinical anesthesiology at the University of Miami Miller School of Medicine. "I expect that some drug company will research further," he said.

And John Casida, senior author of the paper in the April 27 issue of Nature Chemical Biology, stressed that his team "report new fundamental mechanistic discoveries on the cannabinoid system, rather than proposing a medicine or treatment."

Tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, can relieve both pain and anxiety but, unfortunately, also results in cognitive problems such as memory loss.

In fact, one recent study found that multiple sclerosis patients who smoke marijuana in search of symptom relief are more likely to suffer cognitive shortfalls and mood disorders, such as depression and anxiety.

Casida and his colleagues at the University of California, Berkeley, and the Scripps Research Institute in La Jolla, Calif., found that organophosphorus (OP) nerve agents blocked the breakdown of certain enzymes, which has the end result of stimulating the cannabinoid receptors in the brain.

OP nerve agents work like OP pesticides, leading to an excess of the neurotransmitter acetylcholine in the central and peripheral nervous system.

In this experiment, using mice, the OP compounds had the therapeutic effects of THC (pain relief, lower body temperatures) without the cognitive drawbacks.

"We find that that a single organophosphorus compound is capable of eliciting full-blown cannabinoid effects that mirror those of direct cannabinoid receptor stimulators such as THC," said Casida, who is director of the Environmental Chemistry and Toxicology Laboratory at Berkeley. "We believe our compound does not act directly on the cannabinoid receptors, but instead elicits its effects by blocking the enzymes that degrade the endogenous cannabinoids . . . which in turn stimulate the cannabinoid receptors in the brain."

"Blocking these enzymes not only raises endogenous cannabinoid signaling power but also lowers arachidonic acid levels, which may be relevant for pain relief," Casida added. The arachidonic acid pathway is involved in pain and inflammation.

This raises the tantalizing possibility that, one day, a drug might be developed which has medical value but does not get the patient stoned.

More information

The Drug Policy Alliance has more on medical marijuana.



SOURCES: John Casida, Ph.D., professor, entomology and toxicology, and director, Environmental Chemistry and Toxicology Laboratory, University of California, Berkeley; Dennis J. Patin, M.D., associate professor of clinical anesthesiology, University of Miami Miller School of Medicine; April 27, 2008, Nature Chemical Biology


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. An Alternative to Surgery for Treating Skin Cancer
2. Send Me An Angel(TM) Pairs Senior Citizens With Their Peers in Alternative Care
3. SAPPHIRE trial shows long-term benefit of carotid stenting as alternative to surgery
4. Angioplasty Proves Reasonable Alternative to Bypass Surgery
5. SaltWorks, Inc. Advises Table Salt Alternatives
6. Conseco Declines Partnerships Request for Board Seats; Review of Strategic Alternatives Underway
7. New Findings Support Alternatives to Pap Test
8. Popular alternative therapy for psoriasis performs no better than placebo
9. Kristalose(R) Offers Prescription Alternative to MiraLAX(R) and Other PEG 3350 Products
10. Botox Cosmetic Alternatives Are Available: Surgical Procedures Offer Solution for Wrinkles
11. Natural Alternatives International, Inc. Appoints New Chief Financial Officer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
An Alternative to Medicinal Marijuana
(Date:9/20/2017)... ... 20, 2017 , ... Announced that Clear Global ... services market) has entered into an agreement on September 1, 2017 with The ... is the first private Dental School to launch an online, accredited Post Graduate ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... gather for the National Athletic Trainers’ Association Annual Clinical Symposium and Expo. New ... It is also when Athletic Trainers are acknowledged by their peers with accolades ...
(Date:9/20/2017)... ... 2017 , ... Five consumer packaged goods (CPG) products were selected by the ... Nopavera Plus was named to the short list in the Specialty Supplements ... during presentations at SupplySide Central on Sept. 27 and 28 at Mandalay Bay Resort ...
(Date:9/20/2017)... Eugene, OR (PRWEB) , ... September 20, 2017 , ... ... OSHA 10- and 30-Hour and HAZWOPER 8-, 24- and 40-Hour courses from now until ... , In addition to offering these discounted prices to all businesses and government ...
(Date:9/20/2017)... ... ... “RECYCLED Ezekiel's Plan for Freedom from ADDICTION”: A Bible-inspired ... the creation of published author, Bill Miller. Bill Miller has a unique ... than a decade of addiction to prescription drugs. He has a Bachelor ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... N.Y. , Sept. 6, 2017   PDI , ... announced it will host an educational session focused on ... bloodstream infection (CLABSI) prevention at the 2017 Annual Scientific ... which will take place at the Phoenix ... from Sept. 16-19, will also feature PDI,s ...
(Date:9/5/2017)... N.J. , Sept. 5, 2017  Getinge, ... has created a vibrant charitable donation program -- ... and support congenital heart defect research by The ... providers and the general public are encouraged to ... and submit the completed artwork to the gallery ...
(Date:9/1/2017)... 1, 2017  Bayer will present the latest research from ... Medical Oncology (ESMO) 2017 Congress, September 8-12 in ... preclinical and clinical data on Bayer,s marketed portfolio and late-stage ... "We value the ... cancer research at ESMO," said Carsten Brunn , Head ...
Breaking Medicine Technology: