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An AIDS-related virus reveals more ways to cause cancer, Penn researchers find
Date:10/8/2007

ch KSHV subverts control of normal cell growth. Robertsons group previously found that LANA marks tumor suppressors, such as p53 and VHL, for degradation.

Other herpes viruses, such as the one that causes cold sores and Epstein-Barr virus, which causes mononucleosis, are able to hide out in cells as well. Whether these latent herpes viruses use some of the same strategies that we have found for LANA in KSHV has not been determined, says Robertson.

This new role for LANA was discovered using specific human cell lines. The next step is to test whether LANA works the same way in animals infected with KSHV. We have completed some studies in mice that indicate that LANA can contribute to tumor development in an animal in ways similar to what we have observed in cell culture, says Robertson. The animal models will be useful for testing new drug therapies that may inhibit the activity of LANA and eventually prevent the growth of viral-associated cancers.

This work was funded by the National Institutes of Health and the Leukemia and Lymphoma Society of America. Co-authors are Ke Lan of Penn and the Chinese Academy of Science, and S.C. Verma, M. Marakami, B. Bajaj and R. Kaul, all from Penn.

This release is available at www.pennhealth.com/news


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Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

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