Navigation Links
Amyloid imaging shows promise for detecting cardiac amyloidosis
Date:2/4/2013

Reston, Va. While amyloid imaging may now be most associated with detecting plaques in the brain, it has the potential to change the way cardiac amyloidosis is diagnosed. According to first-of-its-kind research published in the February issue of The Journal of Nuclear Medicine, positron emission tomography (PET) with 11C-PIB can positively visualize amyloid deposits in the heart. Currently there is no noninvasive test available for specific diagnosis.

Cardiac amyloidosis is a deadly disorder caused by abnormal amyloid deposits in the heart tissue. Early diagnosis before structural change to the heart tissue has occurred is important for disease prognosis and for treatment monitoring. Currently echocardiography is the mainstay of imaging in cardiac amyloidosis; a cardiac biopsy is used to confirm diagnosis.

"Imaging with 11C-PIB provides a non-invasive and specific means of showing distribution of amyloid in an organ. This gives a unique opportunity to follow and monitor therapy, as amyloid deposits in the heart should decrease with successful therapy," said Gunnar Antoni, PhD, lead author of the study "In Vivo Visualization of Amyloid Deposits in the Heart with 11C-PIB and PET."

The study included 10 patients diagnosed with cardiac amyloidosis and five healthy individuals. PET/computed tomography (CT) with 11C-PIB was used to visualize amyloid deposits in the heart and with 11C-acetate to measure myocardial blood flow.

Uptake of 11C-PIB was measured 15-25 minutes after injection. Obvious uptake of 11C-PIB was noted in the left ventricle wall of all patients with cardiac amyloidosis, while no uptake was seen in the healthy volunteers. In half of the patients, 11C-PIB was also detected in the right ventricle wall, and nine of the patients had signs of reversible uptake, with a maximum concentration at 10-15 minutes after injection. Myocardial blood flow was significantly lower in patients with cardiac amyloidosis; however, no significant correlation between myocardial blood flow and 11C-PIB uptake was found.

"This study emphasizes the strength of molecular imaging for detecting an underlying and significant molecular aberration in a disease that presents with unspecific symptoms and signs," noted Antoni. "The potential for molecular imaging to provide valuable information for other diseases is of great value to the field of medicine."


'/>"/>

Contact: Susan Martonik
smartonik@snmmi.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related medicine news :

1. First guidelines for brain amyloid imaging in Alzheimers released
2. Amyloid imaging helps in evaluating possible Alzheimer disease
3. BUSM researchers part of multi-center study on cardiac amyloidosis
4. Breast Imaging (Breast MRI) Market is Growing at an Estimated CAGR of 15.37% & to Reach $5 Billion by 2017 - by MarketsandMarkets
5. Study: Transparent pricing doesnt curb doctors use of high-cost hospital imaging tests
6. Researchers design a new imaging technique for identifying the age and sex of a corpse
7. Pill-sized device provides rapid, detailed imaging of esophageal lining
8. Imaging Musculoskeletal Trauma: Interpretation and Reporting
9. Imaging study examines effect of fructose on brain regions that regulate appetite
10. Combination of imaging exams improves Alzheimers diagnosis
11. Prostate cancer now detectable by imaging-guided biopsy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... ... meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s to ... and tested to meet the highest standard. , These products are also: ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical ... Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. ... honor of Morris F. Collen, a pioneer in the field of medical informatics, this ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare events ... Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the ... The annual award competition recognizes editorial and design excellence across a range of sectors. ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... On Saturday, ... a treadmill relay – Miles by Moonlight to raise money for the American Heart ... or more. , Teams will work together to keep their treadmills moving for ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... -- The Rebound mobile app is poised to become a ... of prescription drug addiction. The app empowers users to develop ... down their dosage in a safe, controlled manner while maximizing ... first 100,000 people to sign up will enjoy 3 months ... ...
(Date:9/28/2017)... 2017 Cohen Veterans Bioscience and Early Signal ... wearable and home sensors for real-time monitoring of patients ... a nonprofit organization focused on disruptive health solutions for ... analytical system to record and integrate behavioral, cognitive, physiological ... ...
(Date:9/27/2017)... Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... its MyDario product is expected to appear on The Dr. Oz Show ... Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show kicked off ... The segment features ...
Breaking Medicine Technology: