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Amylin Sends Letter to Shareholders
Date:5/1/2009

pts to avoid a proxy contest. We offered Board representation to both Mr. Icahn and Eastbourne before they each gave notice of intent to nominate separate slates of five individuals. Since then we have engaged in additional discussions with Mr. Icahn and Eastbourne, both separately and together, to discuss potential settlement options with respect to the proxy contest. To accelerate this process, Amylin has agreed with affiliates of Mr. Icahn and with Eastbourne to allow each of them to engage in discussions with the other for the sole purpose of facilitating a settlement of the proxy contest.

Mr. Icahn and Eastbourne are each advancing an agenda that we believe undermines Amylin's strategy and jeopardizes the potential value creation of exenatide once weekly. In short, their agenda is to drastically cut costs well beyond our already significant cost-reduction initiatives and push for a sale of the Company at a time when it is seriously undervalued.

PROTECT VALUE OF YOUR INVESTMENT -- VOTE FOR YOUR COMPANY'S NOMINEES ON THE BLUE PROXY CARD TODAY

We urge you to act today to protect your investment by voting your BLUE proxy card TODAY. Please discard any Gold or White proxy cards you might receive from Icahn or Eastbourne, respectively.

We thank you for your continued support.

On Behalf of Your Board of Directors.

    Sincerely,

    /s/  Daniel M. Bradbury                    /s/  James N. Wilson
    Daniel M. Bradbury                         James N. Wilson
    President and Chief Executive Officer      Lead Independent Director

Your Vote Is Important, No Matter How Many Or How Few Shares You Own

If you have questions about how to vote your shares, or need additional assistance, please contact the firm assisting us in the solicitation of proxies:


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SOURCE Amylin Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
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