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Amylin Pharmaceuticals Reports First Quarter Financial Results
Date:4/21/2008

or $0.38 per share, for the same period in 2007.

First Quarter 2008 Highlights

Highlights of Amylin's first quarter include:

BYETTA

-- Submitted a supplemental New Drug Application, or sNDA, to the Food and

Drug Administration, or FDA, to seek approval for expanded use of

BYETTA as monotherapy, or stand-alone therapy, in people with type 2

diabetes who are not achieving acceptable blood sugar control.

Approval for this expanded indication is expected in the second

half of 2008.

SYMLIN

-- Commercially launched the SymlinPen(TM) 120 and the SymlinPen(TM) 60

pen-injector devices for administering SYMLIN in the United States in

January 2008. These new pre-filled pen-injector devices feature

simple, fixed dosing to improve mealtime glucose control.

Exenatide once weekly

-- Initiated the first of three planned superiority clinical trials of

exenatide once weekly. The study compares exenatide once weekly to a

thiazolidinedione, or TZD, and a DPP-4 inhibitor in patients on

background metformin therapy. Results from this study are expected in

the first half of 2009.

-- Continued progress at the Company's exenatide once weekly manufacturing

facility in Ohio, including the manufacture of exenatide once weekly at

commercial scale. The Company plans to supply material from the

facility to support ongoing and planned clinical programs by the third

quarter of 2008

Conference Call

Amylin will webcast its Quarterly Update Conference Call today at 8:30 a.m. ET/5:30 a.m. PT. The call will be webcast live through Amylin's corporate website, http://www.amylin.com, and a recording will be made available following the close of the call.

Daniel M. Bradbury, Amylin's President and Chief Executive Officer, will
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SOURCE Amylin Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

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