Amylin Advises All Shareholders to Vote Their Blue Proxy ...(port or have already voted for all twelv...),Health

As previously announced, Amylin's 2009 Annual Meeting of Stockholders will be held at 8:30 a.m., Pacific Standard Time, on Wednesday, May 27, 2009, at Amylin's offices located at 4575 Eastgate Mall, San Diego, CA 92121.

         Your Vote Is Important, No Matter How Many Or How Few Shares You Own

            If you have questions about how to vote your shares, or need
                                additional assistance,
       please contact the firm assisting us in the solicitation of proxies:

                             INNISFREE M&A INCORPORATED
                   Stockholders Call Toll-Free: (877) 717-3926
                  Banks and Brokers Call Collect: (212) 750-5833

                                      IMPORTANT
      We urge you NOT to vote using any White or Gold proxy card sent to you
       by Icahn or Eastbourne, as doing so will revoke your vote on the BLUE
                                     proxy card.

         If you have already done so, you have every legal right to change
            your vote by using the enclosed BLUE proxy card to vote today--by
                      telephone, by Internet, or by signing, dating and
                      returning the BLUE proxy card in the postage-paid
                                   envelope provided.

About Amylin

Amylin Pharmaceuticals is a biopharmaceutical company committed to improving lives through the discovery, development and commercialization of innovative medicines. Amylin has developed and gained approval for two first-in-class medicines for diabetes, SYMLIN(R) (pramlintide acetate) injection and BYETTA(R) (exenatide) injection. Amylin's research and development activities leverage the Company's expertise in metabolism to develop potential therapies to treat diabetes and obesity. Amylin is headquartered in
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