Navigation Links
Amphetamine use increases risk of aortic tears in young adults, UT Southwestern researchers report
Date:8/16/2010

DALLAS Aug. 17, 2010 Young adults who abuse amphetamines may be at greater risk of suffering a tear in the main artery leading from the heart, UT Southwestern Medical Center researchers have found.

In the study, published in the August issue of American Heart Journal, researchers examined medical records from nearly 31 million people between 18 and 49 years old hospitalized from 1995 to 2007 and found that amphetamine abuse was associated with a threefold increase in the odds of aortic dissection.

"Aortic dissection in young people is rare, but it frequently can lead to death," said Dr. Arthur Westover, assistant professor of psychiatry at UT Southwestern and the study's lead author. "Doctors should screen young adults with aortic dissection for amphetamine abuse in searching for a potential cause."

Individual case reports have suggested a link between aortic dissection and amphetamine abuse, but this is believed to be the first epidemiological study of a large group of people on the issue, Dr. Westover said.

The aorta stems from the heart and is the largest artery in the body. Dissection occurs when a tear develops in the inner layer of the aorta, allowing blood to separate, or dissect. The blood can eventually cause a rupture in the aortic wall, often resulting in death.

Amphetamines are stimulants that can be used to treat medical conditions such as attention-deficit disorder. They also are abused illegally as recreational drugs or performance enhancers. Researchers note that the abuse of amphetamines including methamphetamines, or "meth" significantly increased among hospitalized young adults from 1995 to 2007.

Amphetamines act on the body in similar ways as cocaine, which also is associated with adverse effects on the heart. Medically, amphetamines are known to increase blood pressure, and hypertension is a known trigger of aortic dissection.

Researchers also analyzed medical data for more than 49 million people 50 years or older from the same time period.

"We found that the frequency of aortic dissection is increasing in young adults but not older adults," Dr. Westover said. "It is not yet clear why."

Researchers noted that in California, Hawaii, Oregon and Washington state, the percentage of aortic dissection cases linked to amphetamine abuse among young adults during the study period was three times greater than the national figure.

"This illustrates that in areas where amphetamine abuse is more common, there are greater public health consequences," Dr. Westover said.

Dr. Westover's research previously has linked amphetamine abuse to stroke and heart attack.

"This adds to our growing understanding of the cardiovascular risks associated with abuse of amphetamines," said Dr. Paul Nakonezny, associate professor of clinical sciences and psychiatry at UT Southwestern and an author on the paper.


'/>"/>

Contact: LaKisha Ladson
lakisha.ladson@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Drug control efforts in Mexico reduce methamphetamine treatment admissions in Mexico and US
2. Dental school gets $1.86 million from NIH for study of methamphetamines effect on oral health
3. Researchers ID brain abnormalities in children exposed to methamphetamine in utero
4. Internet access at home increases the likelihood that adults will be in relationships
5. MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment
6. Small increases in vaccine cost can cause large gaps in protection
7. Use of decision-aid program increases safety for women experiencing abuse, researchers find
8. Wood smoke exposure multiplies damage from smoking, increases risk of COPD
9. The Laser Warehouse Increases its Inventory of Used Cosmetic Lasers to Meet Growing Demand
10. Ticking biological clock increases womens libido, new research shows
11. JDR increases its 5-Year SIF and remains number one dental journal of 64 in its category
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... 2016 , ... David J. Dykeman , Ginger Pigott , and ... speak at DeviceTalks West, Dec. 12, 2016, at the Fairmont Newport Beach in California. ... firm’s global Life Sciences & Medical Technology Group have been featured speakers at every ...
(Date:12/8/2016)... Tampa, Fla (PRWEB) , ... December 08, 2016 ... ... offering smarter modes of access for customers and employees that are both engaging ... ChangeGear 7 with Service Smart Technology, the software company revealed today its plans ...
(Date:12/8/2016)... ... 2016 , ... Catalent Pharma Solutions, the leading global provider ... products, today announced that it had joined the Pharmaceutical Supply Chain Initiative (PSCI). ... unite pharmaceutical and healthcare companies that share a vision of better, social, environmental ...
(Date:12/8/2016)... ... December 08, 2016 , ... STAT courier is pleased ... a convenient service for Texas, they are expanding their presence in Dallas. One of ... spree that will bring new jobs to the Dallas and Forth Worth market. STAT ...
(Date:12/8/2016)... ... December 08, 2016 , ... Today’s patients are encouraged to ... mind, SIGVARIS has created a new line of anti-embolism stockings to help prevent ... the benefits of graduated compression when transitioning from recovery to early rehabilitation. , ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... AMSTERDAM , December 8, 2016 Information ... TM metrics in Scopus , the world,s largest ... free access to comprehensive metrics for journals from over 5,000 publishers. ... publish, which journals to subscribe to and when to adjust a ... , , ...
(Date:12/8/2016)... 2016 According to the research report, ... is expected to be worth US$9.7 bn by the ... Between the forecast years of 2016 and 2024, the global ... The leading players operating in the global diabetes injection pens ... plc., Biocon Ltd., and Sanofi S.A. Transparency Market Research reports ...
(Date:12/8/2016)... 2016 According to a new market research report ... Therapeutic (Pain, Insulin)), End Use (Sports, Fitness, RPM), Type (Smart watch, Patch), ... global market, in terms of value, is projected to reach 12.14 Billion ... 18.0% during the forecast period. Continue Reading ... ...
Breaking Medicine Technology: