Navigation Links
Amira Announces the Successful Completion of GLP Toxicity Studies for a Novel DP2 Antagonist.
Date:1/6/2009

Lead candidate on track for IND submission first half of 2009.

SAN DIEGO, Jan. 6 /PRNewswire/ -- Amira Pharmaceuticals, Inc. announced AM211, Amira's internally discovered oral drug candidate for the treatment and control of inflammatory and allergic diseases linked to the arachidonic acid pathway, is on target for submission of an IND to the U.S. Food and Drug Administration (FDA) by mid-2009 following the successful completion of Good Laboratory Practices (GLP) toxicity studies.

AM211 is an oral, selective antagonist of the receptor DP2 (also known as CRTH2 or chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes). DP2 is a high affinity receptor for prostaglandin (PG) D2 and, in humans, is implicated in Th2-dependent allergic inflammation. Recent studies have shown that a DP2 antagonist has the potential to be an oral treatment for asthma, Chronic Obstructive Pulmonary Disease (COPD) and allergic rhinitis.

"Our pre-clinical studies demonstrate that a low dose of AM211 is effective in several inflammatory/allergic models," said Peppi Prasit, PhD, Chief Scientific Officer, Amira. "Based on the pharmacokinetics and pharmacodynamics in preclinical models and its safety profile, we believe that AM211 has the potential to be an exciting next generation, once a day oral medication for respiratory diseases including COPD. In addition, we have a structurally distinct backup compound, AM461, about to enter GLP toxicity studies."

"Amira is establishing a track record of rapid and efficient discovery and early drug development. For the second time in as many programs, Amira is on track to enter human studies within two years from program start," said Bob Baltera, Amira's Chief Executive Officer. "These are exciting times at Amira as our team continues to demonstrate world-class capabilities in drug discovery and development."

About Amira

Founde
'/>"/>

SOURCE Amira Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related medicine news :

1. Amira Pharmaceuticals Achieves Milestones in FLAP Inhibitor Program With GlaxoSmithKline
2. Dr. Dennis Fenton and Dr. Steve Kaldor Join Amira Board of Directors
3. Amira Pharmaceuticals and GlaxoSmithKline Enter Global Agreement for FLAP Inhibitor Program
4. Amira Pharmaceuticals Appoints First Vice President of Development
5. Amira Pharmaceuticals Announces Favorable Phase 1 Clinical Trial Results for Lead Product Candidate AM103 and Initiates Clinical Studies for the 2nd Entry Molecule for the Treatment of Respiratory and Cardiovascular Disease
6. American Asthma Foundation Announces Breakthrough Discovery
7. Galderma Announces Availability of Epiduo(TM) Gel, the First and Only Combination Treatment with a Retinoid and Benzoyl Peroxide to Treat Acne
8. WellPoint Announces Innovative Program to Help Improve the Care of Members Suffering With Bipolar Disorder
9. DiFUSION Technologies Announces Company Launch Focused on Surgical Site Infections (SSIs)
10. FASgen, Inc. Announces Research and License Agreement With Centocor, Inc.
11. B2B Marketing Pro Toby Younis Announces Free Webcast on "BuzzMaking"
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... Seattle, WA (PRWEB) May 22, 2015 According ... adults of all generations are equally as likely to worry ... (72% Millennials, 75% Gen X, 77% Boomers, 69% Silent Generation), ... (45%) agree they are scared of aging, particularly Millennials (47%), ... online by Harris Poll in April, 2015 among more than ...
(Date:5/22/2015)... 22, 2015 Coco Libre, the Official Coconut ... World Record at the 104th running of the race. On ... luge served 315 people in one hour—one person about every ... is so true to the heart of the Bay Area, ... ice luge to the finish line only made sense,” said ...
(Date:5/22/2015)... According to Berks and Beyond , Pennsylvania ... totaling almost 2,500 confirmed drug deaths, as reported on May ... 2,489 deaths stemming from legal and illegal drug use in ... every day to fatal overdoses or other drug related deaths. ... of the most rife with drug related deaths. The city, ...
(Date:5/22/2015)... 2015 Gateway Building Concepts is experienced ... services the company specialize in include decks, additions, kitchen ... houses and much more. , The redesigned logo ... of the company. It includes two geometrical lines that ... thought out to be used with many things associated ...
(Date:5/22/2015)... VA (PRWEB) May 22, 2015 sweetFrog Enterprises, ... location in Jacksonville, Texas. Jacksonville is now the 16th sweetFrog ... yogurt chain was listed as #22 on the Inc. 500 ... “I have lived and worked in East Texas for 20 ... Brad Anderson, owner of the Jacksonville, and nearby Palestine, sweetFrog ...
Breaking Medicine News(10 mins):Health News:New Study Reveals America’s Fear of Aging 2Health News:New Study Reveals America’s Fear of Aging 3Health News:Coco Libre Ice Luge Sets New World Record at Bay to Breakers 2Health News:Philadelphia Ranks Among the Tops Cities in Penn. for Drug Deaths 2Health News:sweetFrog Opens New Location in Jacksonville, Texas 2
... New York - To gauge the efficacy of food ... researchers at the Vanderbilt University for Health Services //embarked ... survey revealed, despite the enduring habit of reading food-labels, ... did not assimilate the information. The pointers that consumers ...
... California in Los Angeles reveals that in general, doctors give ... take the medication properly. // ,“This is a good ... patients and doctors,” said the lead author Derjung M. Tarn., ... the journal Archives of Internal Medicine. ,In order ...
... announced the commencement of trials of a new vaccine against ... adults on Tuesday.// ,According to the researchers, the ... vaccines on the markets that are life saving. ... vaccines that make life better," said Dr. Michael Pichichero, a ...
... illegal medicines are flooding the South African market with ... said many medicines claim to cure cancer, tuberculosis and ... industry had grown out of control. "The belief is ... too large. So the department is not enforcing the ...
... yesterday to see if parents supported the proposal to ban ... 1,000 votes in support//. ,"Ofcom has argued ... food advertising would be "disproportionate'," said NHF deputy chief executive ... witness to the widespread and rising concern about the damage ...
... ultrasound sight of the baby to be born in six months' time//. ... pregnancy is on track. ,This is often the only view ... birth. However this is not enough for an increasing number of parents ... of their baby in the womb. ,The primary purpose of ...
Cached Medicine News:Health News:Doctors to give complete information on prescriptions to patients 2Health News:Doctors to give complete information on prescriptions to patients 3Health News:Vaccine for ear and sinus infections to be developed… 2Health News:Peek Before Birth 2
(Date:5/21/2015)... May 21, 2015 Research ... addition of the "Market Assessment of Respiratory ... report to their offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... respiratory imaging diagnostics market in the ... . The service provides detailed analysis of ...
(Date:5/21/2015)...  Cardica, Inc. (Nasdaq: CRDC ) today announced that ... the company,s vice president of operations, was granted an option ... a per share exercise price of $0.43, the closing trading ... pursuant to Cardica, Inc.,s Inducement Plan, which was approved by ... 5653(c)(4) of the Nasdaq Global Market for equity grants to ...
(Date:5/21/2015)... Mai 2015 Dipexium Pharmaceuticals, ... Unternehmen für Arzneimittel im fortgeschrittenen Entwicklungsstadium, ... Vermarktung von Locilex® (Pexiganan-Creme 0,8 %) und ... wissenschaftliche Posterpräsentation an, welche das innovative ... OneStep-1 und OneStep-2, in der Locilex® ...
Breaking Medicine Technology:United States and Europe Respiratory Diagnostics Market Assessment 2015 2Cardica Announces New Employment Inducement Grant 2Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 2Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 3Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 4Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 5Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 6Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 7
Super High Density, multi frequency Side Fire "T intraoperative transducer. A wide field of view is this transducers benefit. Change frequencies on the fly for deeper penetration or for superficial n...
This is a 3D transducer for endovaginal imaging in OB/GYN....
Super High Density, 120 degree field of view, straight handle, multi-frequency, convex endovaginal transducer....
Prostate biopsy transducer....
Medicine Products: