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Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29

ed" -------- ------------- ---------- Total debt outstanding $11.5 $0.7 (a) $12.2 (a) To exclude the impact of the change in method of accounting for our convertible notes under FSP APB 14-1, as discussed on the preceding pages.

    Amgen Inc.
    Reconciliation of "Adjusted" Earnings Per Share Guidance to GAAP
    Earnings Per Share Guidance for the Year Ending December 31, 2009
    "Adjusted" earnings
     per share guidance               $4.80  - $4.95

    Known adjustments to
     arrive at GAAP earnings:
      Amortization of
       intangible assets,
       product technology
       rights                    (a)           (0.18)
      Incremental non-
       cash interest
       expense                   (b)           (0.15)
      Tax settlement             (c)            0.11
      Stock option expense       (d)  (0.06) - (0.08)
      Cost savings
       initiatives               (e)  (0.04) - (0.05)
      Amortization of
       intangible assets,
       R&D technology
       rights                    (f)           (0.04)
      California tax law
       change                    (g)            0.02
      Legal settlements          (h)           (0.01)

    GAAP earnings per
     share guidance                   $4.42  - $4.60

    (a) To exclude the ongoing, non-cash amortization of acquired product
        technology rights, primarily ENBREL, related to the Immunex

    (b) To exclude the incremental non-cash interest expense resulting from
        our adoption of FSP APB 14-1.

    (c) To exclude
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