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Amgen's First Quarter 2009 Adjusted Earnings Per Share Decreased 4 Percent to $1.08
Date:4/23/2009

st quarter of 2008 and the decline in wholesaler inventory levels during the first quarter of 2009, ENBREL sales decreased 5 percent in the first quarter of 2009 versus the prior year, primarily due to a decline in demand. This decline in demand was principally due to a decrease in units sold partially offset by an increase in the average net sales price. ENBREL sales were affected by slowed tumor necrosis factor (TNF) segment growth and increased competitive activity. However, ENBREL continues to maintain a leading position in both the rheumatology and dermatology segments.

Worldwide sales of Sensipar(R) (cinacalcet) increased 11 percent to $148 million in the first quarter of 2009 versus $133 million during the first quarter of 2008, primarily as a result of increased demand.

Vectibix(R) (panitumumab) sales for the first quarter were $53 million as compared to $34 million in the first quarter of 2008. Sales growth for the first quarter was driven by international demand as a result of recent launches of Vectibix in Europe, partially offset by lower U.S. demand.

Operating Expense Analysis on an Adjusted Basis:

Cost of sales decreased 13 percent to $474 million in the first quarter of 2009 versus $542 million in the first quarter of 2008. This decrease was primarily driven by lower sales volume and favorable product mix.

Research & Development (R&D) expenses were $605 million in the first quarter of 2009 versus $661 million in the first quarter of 2008, a decrease of 8 percent. This decrease was primarily driven by lower clinical trial costs for the denosumab registrational studies due to completion of enrollment, lower motesanib clinical trial costs associated with the delay of the non-small cell lung cancer trial (NSCLC), lower staff related costs, and increased partnership expense recoveries.

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