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American Heart Association Meeting Report: High-Sugar Diet Increases Men's Blood Pressure; Gout Drug Protective
Date:9/23/2009

CHICAGO, Sept. 23 /PRNewswire-USNewswire/ --

Study 1 highlights:

  • Just two weeks on a high-fructose diet raises blood pressure in men.
  • A drug used to treat gout seems to protect against that blood pressure increase and some aspects of metabolic syndrome.

Study 2 highlights:

  • A study in mice finds that the time of day when fructose is consumed is linked to abnormalities in blood pressure, weight gain and behavior.

Abstract P127

A high-fructose diet raises blood pressure in men, while a drug used to treat gout seems to protect against the blood pressure increase, according to research reported at the American Heart Association's 63rd High Blood Pressure Research Conference.

"This is the first evidence of a role of fructose in raising blood pressure and a role for lowering uric acid to protect against that blood pressure increase in people," said Richard Johnson, M.D., co-author of the study and professor and head of the division of Renal Diseases and Hypertension at the University of Colorado-Denver medical campus in Aurora, Colo.

In the study, excessive fructose consumption seemed to increase new onset of metabolic syndrome, a cluster of risk factors associated with the development of cardiovascular disease and type 2 diabetes. On the other hand, the gout drug seemed to halt it -- most likely by lowering uric acid, which affects blood pressure.

Fructose, one of several dietary sugars, makes up about half of all the sugar molecules in table sugar and in high-fructose corn syrup, a sweetener often used in packaged products because it's relatively cheap and has a long shelf life. Glucose makes up the other half. Fructose is the only common sugar known to increase uric acid levels.

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SOURCE American Heart Association
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