Navigation Links
American Heart Association Late Breaking Clinical Trial Report: In Patients on Statins, Raising Good Cholesterol with Niacin, but not Reducing Bad Cholesterol with Ezetimibe, Decreases Plaque Build-Up
Date:11/15/2009

up as compared to the niacin group (5 percent vs. 1 percent).

HDL And LDL Treatment Strategies (HALTS) was a prospective, randomized, parallel group, open-label, blinded endpoint study conducted at Walter Reed Army Medical Center in Washington, D.C., and Washington Adventist Hospital in Tacoma Park, Md. It included 363 adults (80 percent male, average age 68 years) with or at high risk for atherosclerotic cardiovascular disease.

All participants were on cholesterol-lowering statin drugs, and their LDL cholesterol was at the treatment goal of under 100 milligrams per deciliter (mg/dL) of blood. Their HDL cholesterol was lower than 50 mg/dL for men and 55 mg/dL for women.

The researchers randomly assigned the subjects to receive either niacin or ezetimibe in addition to their usual statin. The primary endpoint was the change in the wall thickness of the carotid artery in the neck between the two groups of patients. In June, researchers halted the trial early because the primary endpoint was met. Specifically, 14-month follow-up data on 208 patients showed that in the niacin group, average HDL cholesterol rose from 42 mg/dL to 50 mg/dL and there was a significant regression in artery wall thickness. In the ezetimibe group, average LDL cholesterol levels dropped from 83 mg/dL to 66 mg/dL; however no overall change was found in average artery wall thickness.

LDL cholesterol is generally linked to the buildup of plaque in the arteries, which makes them more likely to become narrowed, and can lead to heart attack or stroke. HDL cholesterol helps clear LDL cholesterol from the blood in a process called reverse cholesterol transport.

"These findings for ezetimibe are counter to the prevailing understanding of LDL cholesterol -- that lowering LDL cholesterol results in slowing of the atherosclerotic process as has been convincingly shown for other classes of lipid modifying drugs, such as statins an
'/>"/>

SOURCE American Heart Association
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. American Heart Associations Scientific Sessions Media Alert
2. American Heart Association Late Breaking Clinical Trial Report: Tests Predict Which Patients Are Resistant to Anti-Clotting Therapy During Angioplasty, Stenting
3. LTC Awareness Month Finds Americans Still in Dark about Long-Term Care
4. New Poll Finds 71 Percent of Americans Favor Investing More in Disease Prevention as Central to Health Reform
5. Regence Recognized as an American Heart Association Start! Fit-Friendly Company
6. African-Americans with colorectal cancer have poorer outcomes, lower survival rates
7. American Red Cross Auctions Historical Artifacts Through OLS Trading, Inc
8. American Academy of Physician Assistants Applauds U.S. House of Representatives for Passing Health Care Reform Bill
9. Give an Hour(TM) Partners with American Red Cross and Calls All Mental Health Professionals in Texas to Volunteer Their Services
10. Statement by American Heart Association CEO Nancy Brown on Passage of the Affordable Health Care for America Act in the U.S. House of Representatives
11. Americans United for Life Action Comments on Passage of Pro-Life Amendment: Bipartisan Pro-life Majority Reflects the Will of the American People
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... 20, 2014 Ticket Down is ... tickets for her 2015 “Honeymoon Tour.” This well-known ticket ... added savings. , In early 2015, fans will have a ... world across North America. Twenty-one-year-old Ariana Grande will hit the ... take her to 25 cities across the United States and ...
(Date:9/20/2014)... Winston-Salem, NC (PRWEB) September 20, 2014 The excitement ... held in Mount Airy, North Carolina. This year the Surry ... that draws people from around the country who are still fans ... Griffith Show is a sitcom that aired on CBS from 1960 ... 9th best show in American television history. Mount Airy, North ...
(Date:9/20/2014)... New York, NY (PRWEB) September 20, 2014 ... million of their customers may have had their credit card ... late last year, spawning a slew of headline articles ... but those weren’t the only eye opening numbers. , ... numbers were stolen, almost like it’s a way to score ...
(Date:9/20/2014)... OH (PRWEB) September 20, 2014 The ... lawsuit is now in its third week in the ... Schulte LLC reports. Court documents indicate that the week ... with testimony from a DePuy Orthopaedics vice president, ... version of the company’s Pinnacle hip replacement. According to ...
(Date:9/19/2014)... New York, NY (PRWEB) September 20, 2014 ... to moderate revenue growth for the Vision Insurance ... kept pace, to the detriment of industry margins. ... to noticeably increase. Industry operators provide coverage for ... as discounted pricing for eyeglasses, contact lens and ...
Breaking Medicine News(10 mins):Health News:Ariana Grande Tickets in New York, Philadelphia, Orlando, Fairfax, Worcester, Toronto, Uncasville, Detroit, Miami, Pittsburgh, Cleveland, and Atlanta On Sale Today 2Health News:Ariana Grande Tickets in New York, Philadelphia, Orlando, Fairfax, Worcester, Toronto, Uncasville, Detroit, Miami, Pittsburgh, Cleveland, and Atlanta On Sale Today 3Health News:Mayberry Days Parade Cars will be Provided by Mount Airy Toyota and Mount Airy Chrysler Dodge Jeep Ram 2Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 2Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 3Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 4Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 5Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 2Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 3Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 4Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 4
... (BRONX, NY) The National Institute of Diabetes and ... of Health (NIH) has awarded Albert Einstein College of ... for the continuation of its Diabetes Research and Training ... supplemental grant for equipment and additional pilot and feasibility ...
... and a friend dares you to eat a raw crayfish ... a severe parasitic infection. Physicians at Washington University School of ... six people who had consumed raw crayfish from streams and rivers ... three have been diagnosed since last September; the latest in April. ...
... high-risk women opt for lumpectomy , TUESDAY, May 25 ... before surgery enhances their chances of being able to ... new research suggests. , The observation was based on ... United States. It focused on postmenopausal women who had ...
... suggest that bacteria residing in the the human intestinal ... developing colon cancer. Scientists from the University of Florida ... of the American Society for Microbiology in San Diego, ... are more frequently detected in subjects with polyps, early ...
... indicated higher, lower risk of disease, study finds , ... germs living in your gut could affect your risk ... signs of the existence of some germs "are more ... can develop into cancer, while other bacterial signatures are ...
... in French . Montreal, May 25, 2010 ... French and English, at local bookstores and pharmacies. Dr. Jean-Daniel ... Department of Ophthalmology, along with two colleagues from France, have ... Macular Degeneration (Annika Parance Publisher; 121 pages). Written to educate ...
Cached Medicine News:Health News:NIH awards $10M to Einstein for diabetes research 2Health News:NIH awards $10M to Einstein for diabetes research 3Health News:Dangerous lung worms found in people who eat raw crayfish 2Health News:Dangerous lung worms found in people who eat raw crayfish 3Health News:Dangerous lung worms found in people who eat raw crayfish 4Health News:Breast Cancer Study Offers New Hope 2Health News:Book on vision loss: AMD affects 1 million Canadians 2
(Date:9/19/2014)... , Sept. 19, 2014 /PRNewswire-iReach/ -- Market ... Hydrochloride Industry, 2009-2019 is a professional and ... Oxybutynin Hydrochloride industry. The report firstly reviews ... its classification, application and manufacturing technology. The ... manufacturers of Oxybutynin Hydrochloride listing their product ...
(Date:9/19/2014)... 19, 2014 Research ... the addition of the "Global Gynecological ... offering.      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... classified into wide categories based on their ... treatment of different gynecological conditions that affect ...
(Date:9/19/2014)... September 19, 2014 According ... Equipment (Cryotherapy, Heat, therapy, Hydrotherapy), Accessories (Posture Mirror, Exercise ... Advanced technologies - Global Forecast to 2019" published ... to reach $19,786.3 Million by 2019 from $14,240.0 ... from 2014 to 2019. Browse 74 ...
Breaking Medicine Technology:Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 3Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 4Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 5Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 2Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 3Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 2Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 3Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 4
... catheter is designed to remove thrombus ... saline jets travel backwards at half ... a low pressure zone causing a ... the catheter where it is fragmented ...
... Electroanatomical Mapping System combines the legendary accuracy ... ease of Windows* software. It integrates ... new tools that enhance your clinical capabilities ... into the future of EP. The ...
... are meeting the clinical needs of ... anesthesiologists. And, they are of the ... Medtronic.,Effective pacing with the adjustment of ... quick battery changes. Both the ...
... The Kantrowitz CardioVad is a unique left ventricular ... more effectively. It is being used in a ... heart failure as part of an FDA-approved Feasibility ... and disconnect the external power source for minutes ...
Medicine Products: