Navigation Links
American College of Cardiology/American Heart Association Comment on the FDA Public Health Advisory Regarding a Drug Interaction Between Clopidogrel and Omeprazole

ORLANDO, Fla., Nov. 17 /PRNewswire-USNewswire/ -- Today the FDA notified healthcare professionals of new safety information concerning a drug interaction between clopidogrel, an anti-clotting medication, and omeprazole, a proton pump inhibitor (PPI) used to reduce stomach acid.

The FDA notes that they have new data showing that when healthy volunteers received clopidogrel with omeprazole, clopidogrel was less effective in its anti-clotting action than when given without omeprazole. The data are not yet peer-reviewed and published; however the FDA recommends that patients who are using clopidogrel should consult with their healthcare provider if they are currently taking or considering taking omeprazole, including Prilosec OTC.

Clopidogrel is often prescribed to people who have chest pain, have had a heart attack or undergone an artery-opening procedure such as angioplasty or stenting. Effective anti-clotting therapy is proven to reduce the risk of another heart event.

Since clopidogrel can cause bleeding in the stomach, medications like omeprazole may be used in combination to reduce stomach acid and prevent stomach bleeding. Omeprazole is available both by prescription and as an over-the-counter preparation (Prilosec OTC) used to treat frequent heartburn.

The FDA public health advisory lists other medications including antacids and medicines that reduce stomach acid (ranitidine, famotidine, nizatidine) that do not interfere with the anti-clotting activity of clopidogrel, but they suggest that cimetidine should not be used.

The FDA's statement is not based on any new published, peer-reviewed clinical trials showing changes in cardiovascular outcomes.

Visit for the full FDA announcement.

The American Heart Association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) that also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing science content. Revenues from pharmaceutical and device corporations are available at

SOURCE American Heart Association; American College of Cardiology

SOURCE American Heart Association; American College of Cardiology
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Highlights of NHLBI-supported research presented at American Heart Associations Scientific Sessions
2. Mississippi Baptist Medical Center Receives American College of Cardiology Foundation's NCDR ACTION Registry-GWTGTM Gold Performance Achievement Award
3. The ZigBee Alliance and the American Telemedicine Association to Collaborate on Advancing Use of Telehealth Solutions
4. United American Healthcare Corporation Announces Fiscal 2010 First Quarter Results
5. American Heart Association Late Breaking Clinical Trial Report: In Patients on Statins, Raising Good Cholesterol with Niacin, but not Reducing Bad Cholesterol with Ezetimibe, Decreases Plaque Build-Up
6. American Heart Associations Scientific Sessions Media Alert
7. American Heart Association Late Breaking Clinical Trial Report: Tests Predict Which Patients Are Resistant to Anti-Clotting Therapy During Angioplasty, Stenting
8. LTC Awareness Month Finds Americans Still in Dark about Long-Term Care
9. New Poll Finds 71 Percent of Americans Favor Investing More in Disease Prevention as Central to Health Reform
10. Regence Recognized as an American Heart Association Start! Fit-Friendly Company
11. African-Americans with colorectal cancer have poorer outcomes, lower survival rates
Post Your Comments:
(Date:6/24/2016)... ... , ... Those who have experienced traumatic events may suffer from a complex ... as drug or alcohol abuse, as a coping mechanism. To avoid this pain and ... a traumatic event. , Trauma sufferers tend to feel a range of emotions, from ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... Fla. (PRWEB) , ... June 24, 2016 , ... Global ... Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition ... Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this year’s ...
(Date:6/24/2016)... ... , ... Comfort Keepers® of San Diego, CA is excited to announce they ... to drive cancer patients to and from their cancer treatments. Comfort Keepers provides ... life and ongoing independence. Getting to and from medical treatments is one of ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are ... Code Talker Award, an essay contest in which patients and their families pay tribute ... presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... HILLS, Calif. , June 23, 2016 Any ... the many challenges of the current process. Many of them ... because of the technical difficulties and high laboratory costs involved. ... have to offer it at such a high cost that ... afford it. Dr. Parsa Zadeh , founder ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that it ... (procalcitonin) assay as a dedicated testing solution for people ... Roche is the first IVD company in the U.S ... assessment and management. PCT is a sepsis-specific ... blood can aid clinicians in assessing the risk of ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... offering. The current unmet ... for MedImmune to enter. The US ageing population creates a ... considerable growth for effective anti-influenza medications. The introduction of a ... development is still in its infancy. Key ...
Breaking Medicine Technology: