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American Chemical Society's Weekly PressPac -- March 4, 2009
Date:3/9/2009

NTACT:
Thomas Hofmann, Ph.D.
Chair of Food Chemistry and Molecular Sensory Science
Technische Universitt Mnchen
Freising-Weihenstephan, Germany
Phone: 49-8161/71-2902
Fax: 49-8161/71-2949
Email: thomas.hofmann@wzw.tum.de


ARTICLE #3 FOR IMMEDIATE RELEASE

New genre of sugar-coated "quantum dots" for drug delivery
Journal of the American Chemical Society

Scientists in Switzerland are reporting an advance that could help tap the much-heralded potential of "quantum dots" nanocrystals that glow when exposed to ultraviolet light in the treatment of cancer and other diseases. They are publishing the first study showing that giving quantum dots an icing-like cap of certain sugars makes these nanoparticles accumulate in the liver but not other parts of the body. That selective targeting could be used to deliver anti-cancer drugs to one organ, without causing the body-wide side-effects that occur with existing cancer drugs, they suggest. Their study is in the Feb. 18 issue of the Journal of the American Chemical Society, a weekly publication.

In the new report, Peter H. Seeberger and colleagues note that quantum dots, about 1/5,000th the width of a human hair, are used in solar cells, medical diagnostic imaging, and electronics. Scientists believe these particles also show promise for drug delivery for treating cancer and other diseases. However, researchers still have not found an ideal way to target these dots to specific tissues or organs in order to maximize their effectiveness and limit toxicity.

They describe development of a new type of quantum dot coated with certain sugar molecules that are attracted to receptors in specific tissues and organs. In a study with laboratory mice, the scientists coated quantum dots with either mannose or galactosamine, two sugars that accumulate selectively in the l
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Contact: Michael Woods
m_woods@acs.org
202-872-6293
American Chemical Society
Source:Eurekalert  

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