Rene L. Galindo, MD, PhD, of the University of Texas Southwestern Medical Center, Dallas, focuses her research on childhood cancer. She is particularly interested in rhabdomyosarcoma, an aggressive cancer of the body's soft tissues. Survival is poor among children with this disease, and those who do survive can have life-long disfigurements that result from surgery and chemotherapy. Dr. Galindo is investigating the mechanism by which an abnormal gene converts a normal cell into a cancer cell with the goal of developing therapies to prevent this process.
Tatiana Kalin, MD, PhD, of the Cincinnati Children's Hospital Medical Center is researching a new approach to combating the progression of lung cancer, the leading cause of cancer-related deaths in in the United States. She is exploring how a particular cell protein called FoxM1, which is abundant in lung cancer and many other cancers, causes a cancer to grow and spread to other organs. Her research will increase understanding of how lung cancer progresses at the molecular level, paving the way for therapies that target the disease at this most basic stage.
Nicholas Marshall, PhD, of the University of Texas at Austin, is studying a cell protein called kynurenine that enhances cancer cell growth and suppresses the body's immune system. Various studies have shown that the higher the level of kynurenine in the blood, the poorer the prognosis for a person with cancer. Dr. Marshall is working on a technology to degrade kynurenine to inhibit tumor production and strengthen the immune system.
Alec Kimmelman, MD, PhD, of the D
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American Cancer Society