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American Cancer Society awards 152 new research and training grants
Date:5/17/2010

ew drugs showing any benefit in pancreatic cancer. Dr. Brody proposes to utilize an exciting nanotechnology approach to increase the levels of HuR in all patients to potentially enhance the therapeutic benefit of gemcitabine for a wider range of patients.

  • Dr. Deric Wheeler at the University of Wisconsin discovered that colorectal as well as head and neck cancer cells that have become resistant to the drug Cetuximab show a unique property: the protein targeted by the drug, normally on the cell surface, has 'hidden out' in the nucleus of the tumor cell. He has also identified an enzyme involved in the change, and a drug that can prevent it. The finding has the potential to result in rapid patient benefit to restore the use of this class of drugs in colorectal and head and neck cancer patients.

  • Shailaja Kesaraju, PhD, at Florida Atlantic University is studying the role of mitochondrial function in selective killing of tumor cells by sulindac and DCA. Understanding how the substances kill cancer cells may lead to a more potent combination of drugs.

  • Ken Anderson, MD, PhD, at the Dana-Farber Cancer Institute is seeking to incorporate combined novel therapies into the initial treatment strategy for patients with Multiple Myeloma. Genetic analyses will allow the development and validation of the next generation of targeted therapies for clinical evaluation to further improve patient outcome.

  • Daqing Wu, PhD at Emory Universitv will study the crucial role of the protein survivin and the molecular mechanism for regulation of survivin expression in invasive prostate cancer cells. Results should provide a firm basis for the rational design of novel drugs specifically targeting prostate cancer bone metastasis.

  • Dr. David M. Weinstock at the Dana Farber Cancer Institute will identify genes with abnormal DNA involved in blood cancers (leukemia, lymphoma, multiple myeloma and others). Some of the abnormalities discovered can
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  • Contact: David Sampson
    david.sampson@cancer.org
    American Cancer Society
    Source:Eurekalert

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