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American Cancer Society awards 143 research grants to investigators at 83 institutions nationwide
Date:4/24/2009

get for treatment of acute myeloid leukemia (AML), a devastating cancer of the white blood cells with few therapeutic options available. She will test a drug candidate, R788, for safety and activity prior to consideration for analysis in humans.

  • Siddharth Balachandran, Ph.D., Fox Chase Cancer Center, has discovered how to make cells that have become resistant to interferons regain drug sensitivity by eliminating two proteins. Blocking the activity of these proteins could dramatically improve the therapeutic benefit of interferon in a broad range of cancer patients.

  • Charles Cobbs, M.D., California Pacific Medical Center, is testing the novel hypothesis that infection of cancer stem cells by human cytomegalovirus (HCMV) leads to the development of brain cancer. If true, currently available antiviral drugs or vaccines might be effective in the prevention and treatment of brain cancer.

    Clinical Cancer Research and Immunology

    • Irene Georgakoudi Ph.D., Tufts University, is focused on developing non-invasive, optical imaging methods that could enable improved cancer detection by finding abnormal cells in the uppermost layer of tissue that covers the body cavities and organs. If cancerous changes are detected when they are confined to this superficial layer, they could be treated more effectively.

    • Wei-Qun Ding, Ph.D., University of Oklahoma Health Sciences Center, will explore anticancer activity of docosahexaenoic acid (DHA), which is found in fish oil. Dr. Ding has found that DHA inactivates an enzyme that is important for the growth of tumor cells, and this grant will further the understanding of DHA's anticancer activity and provide a biological basis for the development of novel strategies in cancer prevention and therapy using DHA.

    • Jun Yan, M.D, Ph.D., University of Louisville, is developing novel ways to induce immune responses against breast cancer which would lead to
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    Contact: David Sampson
    david.sampson@cancer.org
    American Cancer Society
    Source:Eurekalert

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