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American Cancer Society awards 143 research grants to investigators at 83 institutions nationwide
Date:4/24/2009

etics and Biochemistry of Cancer

  • Roger A. Greenberg, M.D., Ph.D., University of Pennsylvania School of Medicine, has discovered a novel protein (MERIT40) that is involved in BRCA1 dependent DNA repair. He will examine the roles of this newly discovered protein to provide new ways to improve the diagnosis and treatment of breast and ovarian cancers.

  • Weihua Zhang, M.D., Ph.D., University of Houston, is looking at activities of a receptor for Epidermal Growth Factor (EGF), which helps control cellular growth. These activities may provide new therapeutic approaches to inhibiting the uncontrolled cell growth of some cancers.

  • Hans-Guido Wendel, M.D., Memorial Sloan-Kettering Cancer Center, will test whether proteins that translate the mRNAs expressed from oncogenic genes respond to small molecules as potential cancer treatments.

Cancer Cell Biology and Metastasis

  • John Wilkinson, Ph.D., Wake Forest University, has found that in prostate cancer, apoptosis inducing factor (AIF) promotes cell survival, unlike its previously established role in promoting cell death (via apoptosis). Dr Wilkinson's work has the ultimate goal of developing new and better treatments for prostate cancer, the most commonly diagnosed cancer in American men.

  • Lorraine Santy, Ph.D., Pennsylvania State University, is studying the mechanisms by which growth factors induce cancer cells to migrate and metastasize. Unlike many studies that focus on the homing of metastatic cells to distant organs, Dr Santy's interest is in how growth factors initiate the process of cell movement. This work could supply a critical new understanding of why mutations called Ras mutations are so common in so many different cancers.

Preclinical and Translational Cancer Research

  • Kimberly Stegmaier, M.D., Dana-Farber Cancer Institute, Boston, Mass. has discovered a novel tar
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Contact: David Sampson
david.sampson@cancer.org
American Cancer Society
Source:Eurekalert

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