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American Brain Tumor Association-Funded Research Spurs Development of New Treatments
Date:11/21/2013

ondria starve the cancer cells of energy, eventually killing the GBM cells.

OLIG2 Inhibitors
Another ABTA-funded study, being conducted by Rajesh Mukthavaram, Ph.D. in the lab of Santosh Kesari, M.D., Ph.D., is advancing research into small molecule inhibitors that target a protein called OLIG2. This protein– which is not active in normal brain tissue–plays an important role because large amounts of OLIG2 are found in almost all gliomas, including GBM. The abundance of this protein drives tumor growth and promotes resistance to radiation therapy. OLIG2 inhibitors will be given following the conclusion of primary treatment, such as surgery, to complement the conventional therapeutic approach. The OLIG2 technology is licensed to San Diego-based Curtana Pharmaceuticals, of which Kesari is a co-founder.

ABTA Discovery Grants are one-year, $50,000 awards that fund high-impact projects with the potential to change current diagnostic or treatment paradigms for adult and pediatric brain tumor care. The ABTA’s $1.6 million investment in innovative science has grown into $3.2 million in follow-on funds—a testament to discovery science potential to change the way brain tumors are diagnosed or treated. To learn more, visit http://www.abta.org/advancing-research.

ABOUT THE AMERICAN BRAIN TUMOR ASSOCIATION
Founded in 1973, the American Brain Tumor Association was first and is now the only national organization committed to funding brain tumor research and providing support and education programs for all tumor types and all age groups. For more information, visit http://www.abta.org.

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