American Academy of Dermatology Research Confirms Genetic Skin Barrier Defect Linked... (flammationstinging or itching. Dr. Hanif...)

American Academy of Dermatology Research Confirms Genetic Skin Barrier Defect Linked to Eczema

Date:2/3/2008

flammation, stinging or itching. Dr. Hanifin cautioned that lotions containing alcohol or other irritants can cause significant irritation to babies who have eczema and advised parents to apply petroleum jelly or other non-liquid emollients to their babies' skin after a bath to moisturize it.

Eczema patients with cracked skin also are more susceptible to developing certain bacterial and viral skin infections, due in large part to the lack of anti-microbial peptides (AMPs) in their outer layer of skin and their defective barrier development -- which may hinder the normal production of these important immune factors present from birth. Normally when the skin is injured, the production of AMPs increases to defend against the invasion and proliferation of microbes that cause infections. In skin affected by eczema, this defense mechanism is not activated properly, allowing greater colonization of microbes and increasing the chance of infection. When this occurs, the skin flares very quickly, becoming more irritated and itchy. Typically, antibiotics are used to treat the infection.

"Overuse and prolonged treatment with antibiotics are real concerns for dermatologists who treat patients with eczema, as they are at risk for developing antibiotic resistance," said Dr. Hanifin. "The new research realm directed at the epidermal barrier and the important immune factors carries the hope that new therapeutic approaches will lead to reduced infections in eczema patients."

For more information on eczema, go to http://www.skincarephysicians.com, a Web site developed by dermatologists that provides patients with up-to-date information on the treatment and management of disorders of the skin, hair and nails.

Headquartered in Schaumburg, Ill., the American Academy of Dermatology (Academy), founded in 1938, is the largest, most influential, and most representative of all dermatologic associations.
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SOURCE American Academy of Dermatology
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American Academy of Dermatology Research Confirms Genetic Skin Barrier Defect Linked...(flammationstinging or itching. Dr. Hanif...),Health