American Academy of Dermatology Research Confirms Genetic Skin Barrier Defect Linked... (thyosis vulgaris a geneticdisease charac...)

American Academy of Dermatology Research Confirms Genetic Skin Barrier Defect Linked to Eczema

Date:2/3/2008

thyosis vulgaris, a genetic disease characterized by dry, scaly skin. In both diseases, it is believed that mutations in the filaggrin gene responsible for the proper development and functioning of the skin's impermeable outer layer cause a defect that allows irritants to penetrate the skin.

This new information supplements other recent findings showing that when food allergens pass through the skin, they produce much greater levels of IgE antibodies -- the skin-sensitizing antibodies made by the body that are linked to allergic reactions and cause rapid, and sometimes dangerous, allergic reactions to food. Dr. Hanifin estimated that 30 percent to 40 percent of kids with severe eczema will develop food allergies from increased levels of IgE antibodies, with eggs, peanuts, milk, seafood, soy and wheat posing the biggest threat.

Dr. Hanifin is hoping that this new research will dispel the common misconception that food allergies cause eczema. Rather, the food allergies are secondary to the broken skin barrier caused by eczema.

"When kids develop eczema, their parents are desperate to find out what is causing the condition, and allergies are an easy, but often mistaken, target," said Dr. Hanifin. "Because of the barrier defect, eczema patients typically have the highest prevalence and the most positive blood or skin tests not only to foods, but to dust mites, pollen and pets. However, these are only tests and only a small proportion of the tests coincides with an actual allergy. On the other hand, the strong evidence linking a broken skin barrier to the development of future allergies offers an important prevention opportunity. Babies with eczema need early therapy with measures directed at repair and maintenance of the skin's barrier."

In addition to food allergens, irritants in the form of lotions, soaps or fragrances also pose problems for eczema patients. When the skin cracks and breaks, irritants are passed through the skin and cause in
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SOURCE American Academy of Dermatology
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American Academy of Dermatology Research Confirms Genetic Skin Barrier Defect Linked...(thyosis vulgaris a geneticdisease charac...),Health