Navigation Links
Ambulatory oxygen rarely a benefit in COPD patients without resting hypoxemia

Prescribing ambulatory oxygen in patients with chronic obstructive pulmonary disease (COPD) improves exercise performance, but not the quality of their daily life unless they have resting hypoxemia, according to researchers in Toronto.

Ambulatory oxygen therapy is routinely prescribed for those who do not meet criteria for mortality reduction, wrote Roger S. Goldstein, M.B., Ch.B., Professor of Medicine and Physical Therapy at West Park Healthcare Centre in Toronto, lead author of the study. [This study] suggests serious problems with the indiscriminate use of oxygen to relieve day-to-day dyspnea in patients with COPD without resting hypoxemia.

The study, which indicates that generalized treatment of COPD patients with ambulatory oxygen may be an unnecessary and inconvenient, and possibly even detrimental expense, appeared in the second issue for August of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

For many patients, a diagnosis of COPD comes with a prescription for ambulatory oxygen, even when they do not meet the standard criteria for long-term oxygen treatment (LTOT). In 2002, Medicare paid $2.2 billion for home oxygen therapy.

The researchers conducted a series of double-blind N-of-1 trials wherein 27 COPD patients without resting hypoxemia underwent three pairs of two-week trials, using either oxygen or compressed air (as a placebo). At the end of each trial period, patients were assessed with the Chronic Respiratory Questionnaire (CRQ) and St. Georges Respiratory Questionnaire (SGRQ), and given a timed walk test to assess their exercise performance. Neither the patients nor the assessors were aware of whether they had received oxygen or placebo during the trials.

As a group, the patients on oxygen showed improvement in the number of steps taken in the walk test, but no improvement in their dyspnea scores or on their questionnaires. When assessed as individuals who served as their own controls, four patients showed improvement in the dyspnea scores with oxygen, and only one was identified as a clear responder, whose overall scores and walk tests improved markedly on oxygen, and who requested early termination of the placebo phase of the trial during all three periods.

Although ambulatory oxygen acutely improved constant power endurance and a standardized home walking test, very few patients experienced benefit from oxygen at home, wrote the researchers.

These results are consistent with those in previous studies, which have likewise found that improvements in exercise capacity and endurance do not translate into perceived benefits in dyspnea and quality of life. However, one investigation in patients who had completed a pulmonary rehabilitation program, did find differences in the CRQ, suggesting a benefit from oxygen to more active patients.

These findings raise important questions about identifying patients who stand to benefit from oxygen. One approach to the issue is to restrict oxygen use to patients who show benefit from an N-of-1 trial, the researchers suggest, noting that while the costs of such trials are not negligible, they are considerably less than the cost of providing long-term ambulatory oxygen for patients who do not benefit from it.

The study also challenges us to learn what supplemental oxygen therapy can accomplish when coupled with an exercise program designed to potentiate oxygens effects, wrote M. Bradley Drummond, M.D., and Robert A. Wise, M.D., of Johns Hopkins University School of Medicine, in an accompanying editorial. Continued efforts with innovative approaches...will allow the treatment of COPD to move away from the limited data of the past into a future where COPD no longer damages and shortens the lives of so many.


Contact: Suzy Martin
American Thoracic Society

Related medicine news :

1. The advantages of oxygen therapy
2. Oxygen Treatment may be injurious
3. Oxygen helps heal wounds
4. Oxygen Usage During Exercise Could Indicate Heart Problems
5. Oxygen Consumption During Workouts Could Indicate Heart Problems
6. Cooling Can Reduce The Risk Of Brain Damage In Oxygen Deprived Newborns
7. Air travel reduces oxygen level in the blood
8. Influence Of Heart Rate On Myocardial Oxygen Tension
9. Mobilizing Stem Cells at the Injured Site Using Hyperbaric Oxygen Treatments.
10. Stem cells mobilized by hyperbaric oxygen
11. New Sensor To Monitor Oxygen Deprivation In Babies During Birth
Post Your Comments:
(Date:11/27/2015)... ... ... ProSidebar: Fashion is a set of 30 kinetic edge graphics ... editors can easily add an informative sidebar to any FCPX production. Create lists, ... self-animating drop zones, lines, bars, and text with the ease of FCPX's drag and ...
(Date:11/27/2015)... ... 2015 , ... The moment you stop improving is the ... the needs of advisers and clients but going above and beyond to find ... service. However, there's always room for improvement, which is why the entire Consulting ...
(Date:11/27/2015)... ... , ... Avid collector, Andrew Hawley from Vintage Rock Posters, announces his search ... one of Joplin's most famous and beautiful concert posters. The concert was held on ... Arbor. The According to Hawley, "It is hard to believe that Joplin's stardom was ...
(Date:11/26/2015)... ... November 26, 2015 , ... Somu Sivaramakrishnan announced ... franchise owner, Somu now offers travelers, value and care based Travel Services, including ... sales, as well as, cabin upgrades and special amenities such as, shore excursions, ...
(Date:11/26/2015)... ... November 26, 2015 , ... Pixel Film Studios brings Final ... ProTrailer: Vintage. This newly styled ProTrailer pack comes with 30 all-new vintage-inspired designs, ... giving users limitless opportunities to stylize and create designs quickly and easily, all ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... A new combination approach blends immunotherapy with Bremachlorin-photodynamic therapy ... new combination approach blends immunotherapy with Bremachlorin-photodynamic therapy for ... new combination approach blends immunotherapy with Bremachlorin-photodynamic therapy for ... has found that immunotherapy can be efficiently ...
(Date:11/26/2015)... STOCKHOLM , November 26, 2015 ... the potential to use SyMRI to find optimal contrast weighting ... brain tumor metastases, and has signed a research agreement with ... at the hospital. Using SyMRI, it is possible to generate ... parameter settings after the patient has left, thus making it ...
(Date:11/26/2015)... , November 26, 2015 3D bioprinting ... 2022, according to a new report by Grand View Research ... Disease (CKD) which demands kidney transplantation is expected to boost ... effective substitute for organ transplantation. --> 3D bioprinting ... 2022, according to a new report by Grand View Research ...
Breaking Medicine Technology: