'Ambry Genetics Announces Launch of Chromosomal Microarray to Offer Whole Genome...( ALISO VIEJO Calif. June 3 /- Ambry Ge...),Health

ALISO VIEJO, Calif., June 3 /PRNewswire/ -- Ambry Genetics is pleased to announce the launch of whole-genome Chromosomal Microarray Analysis (CMA), offering the Ambry CMA: 105K Oligo Array, which is designed to identify chromosomal abnormalities associated with over 270 genetic disorders. In a partnership with Baylor College of Medicine, Ambry is now able to provide one of the most comprehensive, clinically-validated genetic tests available using array comparative genomic hybridization. Baylor College of Medicine will equip Ambry with an extensive library of over 20,000 patient samples to reference, and expert cytogeneticist support. Ambry is proud to provide Easy-to-Read reports and free specimen submission kits for all their clients. With the addition of aCGH, Ambry now has one of the most extensive genetic testing menus in the industry.

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The Ambry CMA: 105K Oligo array uses 105,000 probes to cover 270 disease loci, with probes at an average resolution of 30Kb along the human genome to detect copy number variations. A copy number variant (CNV) is a region larger than 1 Kb with a variable copy number compared to a reference genome. Humans usually have two copies of each autosomal region, one per chromosome. If only one or no copy is present, the region harbors a deletion, if more than 2 copies are present, it harbors a duplication. Large regions of the human genome are now known to contain CNVs, many of which contribute to normal human variation and are benign. CNVs may contribute to disease if containing genes whose dosage is important for normal function, (pathogenic CNVs). CNVs are actively being studied and classification is ongoing.

"We are very excited to be able to bring this powerful technology to our clients and their patient
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