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Alzheimer's vaccine clears plaque but has little effect on learning and memory impairment
Date:4/4/2008

ough plaques had been cleared from multiple brain regions -- including the entorhinal cortex, a region of the brain involved with learning and memory and primarily affected by Alzheimer's -- damaged neurons remained.

Head said this discovery helps explain why there was little difference in the behavioral test results between immunized and nonimmunized dogs. In addition, she added, it implies that after clearing beta-amyloid plaques from the brain, the next step is to repair these neurons. This approach will be critical for treating and reversing the effects of the Alzheimer's disease.

Currently, Head and her colleagues are developing approaches to repair these damaged neurons and hope to test them clinically.


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Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

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