Navigation Links
Alzheimer's molecule is a smart speed bump on the nerve-cell transport highway
Date:1/17/2008

PHILADELPHIA Researchers at the University of Pennsylvania School of Medicine discovered that proteins carrying chemical cargo in nerve cells react differently when exposed to the tau protein, which plays an important role in Alzheimers disease.

Dynein and kinesin proteins transport cellular cargo towards opposite ends of tracks called microtubules. Tau binds to the microtubule surface and acts like a speed bump to regulate protein traffic, the group found. But it is a smart speed bump because it impedes these different motor proteins to different degrees, explains first author Ram Dixit, PhD, a postdoctoral fellow in the lab of senior author Erika Holzbaur, PhD, Professor of Physiology.

Our findings show a mechanism of regulating the transport of nutrients, signaling molecules, and waste proteins along a nerve cells axon, says Dixit. Neurodegenerative diseases such as Alzheimers arise when pieces of this shipping system goes awry.

The transport performed by dynein and kinesin is required for continuously providing new proteins to the axon and synapse to maintain normal cellular function, and is also required to remove old, misfolded, or aggregated proteins for degradation. Just as important, this transport is required for moving other proteins from the nerve-cell synapse back to the cell body, which is also required to maintain healthy neurons.

In neurons, microtubules are abundantly decorated with tau. Dynein and kinesin encounter the tau molecules on their travels along the microtubules. The Penn group found that dynein, which carries loads towards the interior of the cell, maneuvers around tau; whereas, kinesin, which carries loads towards the outside of the cell, detaches when it encounters tau.

These findings appear online January 17 in Science in advance of print publication.

Dynein and kinesins individual maneuverings when encountering tau allow for the cell to be able to offload cargo whe
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. New class of RNA molecules may be important in human cancer
2. Molecule Promising Against Huntingtons Disease
3. Free Access to Literature Data on Chagas Disease Offered Online: Collaborative Drug Discovery, Inc. provides Neglected Disease researchers with archive mine and collaborate access to small molecule bioactivity SAR data on parasitic disease
4. Vulnerability to Stress Linked to Brain Molecule
5. Amira Pharmaceuticals Announces Favorable Phase 1 Clinical Trial Results for Lead Product Candidate AM103 and Initiates Clinical Studies for the 2nd Entry Molecule for the Treatment of Respiratory and Cardiovascular Disease
6. Study Describes Molecules That Control Blood Pressure
7. Researchers identify molecules with interesting anti-clotting properties
8. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
9. St. Jude finds molecule that could improve cancer vaccines and therapy for other diseases
10. Major Advance in the Observation of DNA Molecules
11. Molecules can block breast cancers ability to spread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Alzheimer's molecule is a smart speed bump on the nerve-cell transport highway
(Date:8/1/2014)... Online retailer Disposable Medical Express has ... guarantee on their inventory of Tranquility incontinence care products. ... pads along with other personal care products. , ... a line of incontinence products that you love,” a ... works for you, you shouldn't have to compromise because ...
(Date:8/1/2014)... Stress management can be difficult in this ... concentration and diminish rest and leisure time, stress can mount ... to find a way to manage stress in order to ... “Having a good sense of work-life balance is the key ... founding clinician of SF Custom Chiropractic. “Stress, left unchecked, can ...
(Date:7/31/2014)... Just in time for Washington’s unusually ... is featuring new summertime drink specials on their famed ... locations throughout the season. , A longtime ... customer-nominated Seattle’s best happy hour is well-known for its ... Union location’s 25th anniversary this summer, Duke is now ...
(Date:7/31/2014)... you have asthma, you may have an asthma action plan ... respond to changes and understand when symptoms are getting worse ... you,re doing well, yellow means your asthma has worsened and ... New guidelines are now available to help your allergist steer ... away from the red zone. , "Management of acute loss ...
(Date:7/31/2014)... The 2013 PolyU TSI hit a record ... in 2012. The index measures inbound tourists’ satisfaction ... into an overall index. The 2013 index indicates ... Hong Kong over time. , The index shows ... in Hong Kong are attractions (79.27) and transportation ...
Breaking Medicine News(10 mins):Health News:Disposable Medical Express Offering Low Price Guarantee On Tranquility Products 2Health News:SF Custom Chiropractic Celebrates National Relaxation Day and the Benefits of Massage Therapy for the Month of August 2Health News:Seattle Seafood Restaurant Lake Union Duke's Chowder House Celebrating its 25th Anniversary, Still a Best Outdoor Deck Spot to Sip Up Cocktails in Record-Breaking Heat. 2Health News:Seattle Seafood Restaurant Lake Union Duke's Chowder House Celebrating its 25th Anniversary, Still a Best Outdoor Deck Spot to Sip Up Cocktails in Record-Breaking Heat. 3Health News:PolyU Released Report On 2013 Tourist Satisfaction and Tourism Service Quality Indices to Boost Tourism Development 2Health News:PolyU Released Report On 2013 Tourist Satisfaction and Tourism Service Quality Indices to Boost Tourism Development 3
... -- Could injecting a gene into a patient with ... Physician-scientists are setting out to answer that question in ... severe heart failure. , NewYork-Presbyterian Hospital/Columbia University Medical ... City area where the therapy is currently available. , ...
... will develop training standards and guidelines to ensure ... keeps pace with growth ... To develop first-of-its-kind,guidelines and training standards for ... disease, the Society for,Cardiovascular Angiography and Interventions (SCAI) ...
... Plans to build a second state-of-the-art CCRC across ... MATTHEWS, N.C., June 18 ACTS Retirement-Life,Communities has ... parcel,located near the intersection of Fullwood Lane and ... to add approximately 350 independent,living apartments and single ...
... U.K. study suggests , , WEDNESDAY, June 18 (HealthDay News) ... of anticipating how people might behave during a psychotic ... University of Cambridge, found that patterns of normal brain ... , The researchers compared the brain activity of 15 ...
... in Nation,s 4th Leading Cancer Killer, BETHPAGE, ... Cancer Research, the largest private foundation dedicated,exclusively to ... Request For Proposals (RFP) to identify promising research ... deaths in the United,States., The Lustgarten Foundation,s ...
... the National ... Injury Prevention Program, WASHINGTON, June ... Safety for Seniors Act of 2008,and urges lawmakers to provide ... Center to fully implement this critical,fall prevention initiative., "Millions ...
Cached Medicine News:Health News:First gene therapy for heart failure offered at NewYork-Presbyterian/Columbia 2Health News:SCAI Creates New Council for Rising Interest in Interventional Therapies for Structural Heart Disease 2Health News:SCAI Creates New Council for Rising Interest in Interventional Therapies for Structural Heart Disease 3Health News:ACTS Retirement-Life Communities Signs Land Purchase Agreement on 48-Acre Site in Matthews, North Carolina 2Health News:Brain Activity May Predict Schizophrenia Behavior 2Health News:Lustgarten Foundation Announces 2009 Request for Proposals (RFP) 2Health News:Samarion Praises Congress for Passage of Safety for Seniors Act of 2008 2
(Date:7/31/2014)... -- Rock Creek Pharmaceuticals, Inc., (NASDAQ: RCPI ... of its lead molecule, Anatabine Citrate, in ... Clinical, The Translational Pharmaceutics Company, based in the ... early development programs. The Company expects to ... of the third quarter with the Medicines Healthcare products ...
(Date:7/31/2014)... 31, 2014 Touro University California,s College of ... as the recipient of a $150,000 grant by the ... University to increase research and classroom space on its ... for the study of health sciences, and will help ... and interests of our students," said Shelley Berkley ...
(Date:7/31/2014)... July 31, 2014 Catylix, Inc. ( ... ( Milpitas, California ) announced today ... and commercialize new fluorination products and related chemistry. ... benefited from the use of substituents that are ... with polarity to improve binding and bioavailability. Fluorinated ...
Breaking Medicine Technology:Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 2Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 3Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 4Touro University California Garners Grant From Long Foundation 2Catylix, Inc. and Aspira Scientific Announce Joint Venture to Commercialize New Fluorination Technologies 2
... mental retardation, birth defects, and autism spectrum and ... in New YorkMADISON, N.J., March 17 Quest ... world,s leading provider of diagnostic testing, information and ... genomic hybridization (aCGH) postnatal test is now available ...
... Inc. announced today that it has achieved proof ... Inhibiting Multiple Pathways) kinase platform by designing a ... of both the PI3K (Phosphoinositide-3-kinase) pathway and the ... SF2626 has demonstrated the ability to inhibit both ...
Cached Medicine Technology:Quest Diagnostics ClariSure(TM) Postnatal Molecular Test Receives Clinical Laboratory Approval from New York State 2Quest Diagnostics ClariSure(TM) Postnatal Molecular Test Receives Clinical Laboratory Approval from New York State 3Quest Diagnostics ClariSure(TM) Postnatal Molecular Test Receives Clinical Laboratory Approval from New York State 4Semafore Achieves a Preclinical Milestone with SF2626, a PI3K-MEK Dual Pathway Kinase Inhibitor 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: