Navigation Links
Alzheimer's molecule is a smart speed bump on the nerve-cell transport highway
Date:1/17/2008

PHILADELPHIA Researchers at the University of Pennsylvania School of Medicine discovered that proteins carrying chemical cargo in nerve cells react differently when exposed to the tau protein, which plays an important role in Alzheimers disease.

Dynein and kinesin proteins transport cellular cargo towards opposite ends of tracks called microtubules. Tau binds to the microtubule surface and acts like a speed bump to regulate protein traffic, the group found. But it is a smart speed bump because it impedes these different motor proteins to different degrees, explains first author Ram Dixit, PhD, a postdoctoral fellow in the lab of senior author Erika Holzbaur, PhD, Professor of Physiology.

Our findings show a mechanism of regulating the transport of nutrients, signaling molecules, and waste proteins along a nerve cells axon, says Dixit. Neurodegenerative diseases such as Alzheimers arise when pieces of this shipping system goes awry.

The transport performed by dynein and kinesin is required for continuously providing new proteins to the axon and synapse to maintain normal cellular function, and is also required to remove old, misfolded, or aggregated proteins for degradation. Just as important, this transport is required for moving other proteins from the nerve-cell synapse back to the cell body, which is also required to maintain healthy neurons.

In neurons, microtubules are abundantly decorated with tau. Dynein and kinesin encounter the tau molecules on their travels along the microtubules. The Penn group found that dynein, which carries loads towards the interior of the cell, maneuvers around tau; whereas, kinesin, which carries loads towards the outside of the cell, detaches when it encounters tau.

These findings appear online January 17 in Science in advance of print publication.

Dynein and kinesins individual maneuverings when encountering tau allow for the cell to be able to offload cargo whe
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. New class of RNA molecules may be important in human cancer
2. Molecule Promising Against Huntingtons Disease
3. Free Access to Literature Data on Chagas Disease Offered Online: Collaborative Drug Discovery, Inc. provides Neglected Disease researchers with archive mine and collaborate access to small molecule bioactivity SAR data on parasitic disease
4. Vulnerability to Stress Linked to Brain Molecule
5. Amira Pharmaceuticals Announces Favorable Phase 1 Clinical Trial Results for Lead Product Candidate AM103 and Initiates Clinical Studies for the 2nd Entry Molecule for the Treatment of Respiratory and Cardiovascular Disease
6. Study Describes Molecules That Control Blood Pressure
7. Researchers identify molecules with interesting anti-clotting properties
8. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
9. St. Jude finds molecule that could improve cancer vaccines and therapy for other diseases
10. Major Advance in the Observation of DNA Molecules
11. Molecules can block breast cancers ability to spread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Alzheimer's molecule is a smart speed bump on the nerve-cell transport highway
(Date:10/22/2014)... By Dennis Thompson ... -- U.S. health officials on Monday officially tightened guidelines for ... with no skin exposure and use of a respirator at ... Prevention decided to issue the tougher rules after two Dallas ... diagnosed in the United States, Liberian national Thomas Eric Duncan. ...
(Date:10/20/2014)... 20, 2014 The newly updated Worldwide ... of thousands of facts, figures and forecasts on the ... medical sector forecast categories the Worldwide Medical Market ... and national views on the worldwide medical market to ... report gives you data for 2010-2019, covering each country ...
(Date:10/20/2014)... October 20, 2014 Allegheny General Hospital’s ... that enables physicians to repair a damaged mitral valve ... MitraClip system, developed by Abbott Vascular , ... progressive and life-threatening condition in which the heart’s mitral ... flow backward from the heart’s left ventricle into the ...
(Date:10/20/2014)... York, NY (PRWEB) October 20, 2014 ... based non-profit organization that helps New Yorkers living ... positive changes toward health, housing, recovery and self-sufficiency. ... have transformed the local community through their tireless ... Director, Marc Shapses , has been selected ...
(Date:10/20/2014)... ATLANTA, Ga. (PRWEB) October 20, 2014 ... networking and relationship-marketing firm, announced today that William ... been named the 2014 ISE® Luminary Leadership Award ... celebrates the achievements of an outstanding leader and ... stewardship and contributions in advancing the information security ...
Breaking Medicine News(10 mins):Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 2Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 4Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 2Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4
... School of Nursing study is the first to reveal ... Published in the NovemberDecember edition of the journal ... death rates among U.S. nurses and emphasize the importance ... , "Nurses witness firsthand how smoking ...
... cancer in its earliest ... ... are expected to die from melanoma this year. In an effort to ... diagnostics, refining detection guidelines and,providing patients with the tools they need to ...
... ColdFusion Web content management solutions, today announced that ... company records, having grown an average of more ... average deal size increased by more than 30%. ... since its inception in 1993. The company’s growth ...
... for all children at Rosecrans ... Center in South Los Angeles, WOONSOCKET, R.I., Nov. 13 ... the grand opening of,a new playground at the Rosecrans Recreation Center ... play together.,Construction of the playground is funded in part by a ...
... 13 HMS Holdings Corp. (Nasdaq:,HMSY) today announced that ... which will be held November 18-19, 2008 at The ... on Tuesday, November 18th at 11:00 am,ET., HMS ... leader in,coordination of benefits and program integrity services for ...
... survey shows economic,stress takes toll on the emotional ... survey, conducted by the American Psychological Association, shows,at ... the economy as their top,stressors. More than half, ... or anger. Forty-six percent indicated they,were worried about ...
Cached Medicine News:Health News:UCLA study reveals smoking's effect on nurses' health, death rates 2Health News:American Academy of Dermatology: Stop Skin Cancer On The Spot 2Health News:American Academy of Dermatology: Stop Skin Cancer On The Spot 3Health News:American Academy of Dermatology: Stop Skin Cancer On The Spot 4Health News:American Academy of Dermatology: Stop Skin Cancer On The Spot 5Health News:American Academy of Dermatology: Stop Skin Cancer On The Spot 6Health News: PaperThin Experiences Record Growth : Grows Revenues, Expands Channel, and Maintains 95%+ Subscription Renewal Rate 2Health News: PaperThin Experiences Record Growth : Grows Revenues, Expands Channel, and Maintains 95%+ Subscription Renewal Rate 3Health News:CVS Caremark All Kids Can Announces the Opening of a Boundless Playground in Los Angeles to Serve Children of All Abilities 2Health News:CVS Caremark All Kids Can Announces the Opening of a Boundless Playground in Los Angeles to Serve Children of All Abilities 3Health News:CVS Caremark All Kids Can Announces the Opening of a Boundless Playground in Los Angeles to Serve Children of All Abilities 4Health News:CVS Caremark All Kids Can Announces the Opening of a Boundless Playground in Los Angeles to Serve Children of All Abilities 5Health News:Economic Stress Takes Toll on Health 2
(Date:10/22/2014)... 2014 A new report by ... type, Form, End user, Application and Geography) - Size, ... Report, Opportunities, Segmentation and Forecast, 2013 - 2020", considers ... on key trends tracked, it is anticipated that the ... by 2020, registering a CAGR of 6.2% from 2014 ...
(Date:10/22/2014)... , Oct. 21, 2014  Early symptoms ... subtle or unnoticed, but new technology, coupled with ... and leading to earlier detection of eye diseases, ... 29 million Americans. If left untreated, these diseases ... blindness. Recently, optometric researchers have ...
(Date:10/22/2014)... 22, 2014 Sanomedics International Holdings, Inc. (OTCQB: ... Global Research & Data Services, demand for thermometers is ... through 2018, as demand for more accurate digital thermometers ... the world,s largest market for thermometers, and one of ... Sanomedics International Holdings, Inc. Sanomedics International Holdings ...
Breaking Medicine Technology:Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 2Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 3Sanomedics International Holdings Analyst Report: Taking Some Heat by BrokerBank Securities, Inc. 2
... Bulletin Board: CVBT) today announces that its,first US site ... clinical,trial for the treatment of severe coronary heart disease. ... they open for,enrollment. For current details about the clinical ... http://www.cvbt.com ., In this Phase II trial, ...
... BOSTON, Sept. 8 FluoroPharma, Inc. announced ... Chief Scientific Advisor,will report on two preclinical ... Tomography (PET) molecular imaging agents for detection,of ... the World Molecular,Imaging Congress, in Nice, France ...
Cached Medicine Technology:CVBT Announces First Site to Begin Patient Enrollment for Its Phase II Heart Trial 2FluoroPharma, Inc. to Report Preclinical Data on Alzheimer's Disease and Prostate Cancer PET Imaging Agents 2FluoroPharma, Inc. to Report Preclinical Data on Alzheimer's Disease and Prostate Cancer PET Imaging Agents 3
Fine abrasive for knife sharpening, 6 grams net...
Knife sharpening back for Standard Knife, C Profile...
Standard knife with box, C profile...
... stage is a refrigerated design for use as ... use with the 8000 sledge microtome, however, it ... refrigerated stage gives a large working area of ... to provide good adhesion between the specimen and ...
Medicine Products: