Navigation Links
Alzheimer's-like brain changes found in cognitively normal elders with amyloid plaques
Date:3/30/2011

Researchers using two brain-imaging technologies have found that apparently normal older individuals with brain deposits of amyloid beta the primary constituent of the plaques found in the brains of Alzheimer's disease patients also had changes in brain structure similar to those seen in Alzheimer's patients. Results of the study, which has received early online publication in the Annals of Neurology, may help identify individuals who could be candidates for therapies to prevent the development of dementia.

"Our findings support the theory that Alzheimer's disease begins many years before symptoms appear and that amyloid plaque is an early sign of this process," says Keith Johnson, MD, Massachusetts General Hospital (MGH) Imaging, senior author of the study. "We see that when amyloid deposits are present, even in cognitively normal individuals, the degenerative changes of Alzheimer's are underway. Long-term studies to track these changes and observe how they evolve are ongoing."

Definitive diagnosis of Alzheimer's disease requires finding amyloid plaques and neurofibrillary tangles in the brain at autopsy. In recent years it has been possible to detect amyloid in living brains by PET scanning with an imaging agent known as Pittsburgh Compound B (PiB). Plaques have been observed in the brains of apparently healthy individuals, as well as those with dementia, but whether the presence of plaques indicates the early stages of Alzheimer's disease is not yet known.

High-resolution magnetic resonance imaging studies have identified characteristic changes in brain structure thinning of key cortical regions and reduced volume of structures such as the hippocampus in persons with mild cognitive impairment, in individuals known to carry gene mutations that directly cause Alzheimer's disease and in diagnosed Alzheimer's patients. A recent study reported similar brain changes in some cognitively normal elders but did not dis
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Longer Breast-Feeding May Be Key to Bigger Brains
2. For potentially crippling dystonia, earlier deep brain therapy gets better, quicker results
3. Deciphering hidden code reveals brain activity
4. UNC physician-scientist receives grant to study breast cancer brain metastases
5. Brain Stimulation Might Help Stroke Patients With Swallowing Problems
6. UCSF, UC Berkeley join forces to advance frontier of brain repair
7. NeuroImage: Multiplexing in the visual brain
8. Steroid May Help Cut Pneumonia Risk After Brain Trauma
9. Bilingual neurons may reveal the secrets of brain disease
10. Rat Study Sheds Light on How Alcohol Affects Young Brain
11. Self-administered light therapy may improve cognitive function after traumatic brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 2014 The Plantrician Project ... educational events, tools and resources for healthcare professionals ... , the world’s leading online cooking school, have ... being needs: Culinary Rx. As an online food ... Rx, scheduled for debut spring 2015, will be ...
(Date:12/19/2014)... Eufaula, Oklahoma, located just 9 miles ... state’s largest lake with more than 600 miles of ... a little more than 3,000 residents, hosted its annual ... 6th of December. , Featuring Santa, Christmas lights and ... on Main Street. Narconon Arrowhead’s parade float participated ...
(Date:12/19/2014)... The Medspa at Hendrick in Abilene, TX ... cosmetic brand Juvéderm. Voluma XC treats volume loss in ... at Hendrick is pleased to be able to offer ... its clients. , Voluma is the first and only ... the mid-face and cheek area. This non-invasive treatment targets ...
(Date:12/19/2014)... 19, 2014 (HealthDay News) -- The intestinal bacteria that ... ulcerative colitis, may be inherited, researchers report. The ... , could help in efforts to prevent the disease ... colitis, the study authors added. "The intestinal bacteria, ... age can have a big impact on your health ...
(Date:12/19/2014)... 19, 2014 (HealthDay News) -- Injectable drug users who ... suicide attempt rate of other substance users, a new ... associated with the risk of suicide attempt and completed ... of Montreal, said in a university news release. "However, ... wanted to know who among substance users were actually ...
Breaking Medicine News(10 mins):Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 2Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 3Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 4Health News:Narconon Arrowhead Debuts Float at Checotah and Eufaula Christmas Parades 2Health News:Narconon Arrowhead Debuts Float at Checotah and Eufaula Christmas Parades 3Health News:Breakthrough New Injectable Dermal Filler Voluma XC Offered by The MedSpa at Hendrick 2Health News:Crohn's, Colitis May Have Genetic Underpinnings, Study Finds 2Health News:Cocaine, Amphetamines May Up Injection Drug Users' Suicide Risk 2
... It's already been established that type 2 diabetes increases the ... also a link between type 1 diabetes and this type ... but still, those with type 1 diabetes have a likelihood ... in non-diabetics. This is similar to the risk those with ...
... disorder and other mental health conditions are potentially around the ... ,The findings, which were based on analysis of ... 6 in the American Journal of Medical Genetics. ... quantum leap in psychiatry,' said the study's lead author, Robert ...
... said that India, home to 12 million blind people, will ... five years before the World Health Organisation (WHO) deadline of ... little above 1.1 percent. And looking at the progress we ... are quite sure that the WHO target of 0.3 percent ...
... by a University of Leicester geologist was recently used by ... exposure of UK troops to depleted uranium (DU) during the ... Professor of Isotope Geology, developed the test with Postdoctoral Fellow ... Frankfurt, Germany, and his colleague Matt Horstwood at the British ...
... the genetic make-up using blood samples to detect certain ... in practice//. Now, scientists have gone a bit further ... that might reveal the latent tendencies in people to ... disorder. ,Such tests would not dictate who ...
... it may be possible to detect certain mental health conditions ... scientists studied the genetic information in immature white blood cells. ... is a quantum leap in psychiatry," said the study's lead ... UI Roy J. and Lucille A. Carver College of Medicine. ...
Cached Medicine News:Health News:Blood Tests may Be Possible for Mental Health Conditions 2Health News:DU Test Finds UK Troops Uranium Free 2Health News:Genetic Tests to Reveal ‘substance Abuse’ Tendenci 2Health News:Genetic Tests to Reveal ‘substance Abuse’ Tendenci 3Health News:Mental Health Conditions Could Be Detected With Blood Tests 2
(Date:12/19/2014)... 2014 Radiology information system ... used to store, manipulate, and distribute patient radiological ... tracking and scheduling system, result reporting, and an ... HIS and other databases improves the hospital workflow. ... scheduling, patient list management, radiology department workflow management, ...
(Date:12/19/2014)... 2014 Research and Markets ( ... "Micro Market Monitor: North American Dermatology Diagnostic ... http://photos.prnewswire.com/prnh/20130307/600769 ... which has resulted in fueling the overall demand ... purpose of these dermatology devices is to assist ...
(Date:12/19/2014)... -- Decision Resources Group finds that the laparoscopic device market ... increase to a value of over $4.3 billion by ... the large direct energy device market. In particular, premium-priced ... to the advantages they offer and as new products ... Resources Group,s coverage of the U.S. laparoscopic device market: ...
Breaking Medicine Technology:The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 3Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3
... based on SIREMOBIL Iso-C, the first truly ... intra-operative 3D-Mode, the 3D-dataset is immediately available ... movement. This allows the surgeon to perform ... the procedure. This 3D capability is especially ...
... restricted to small central fields, unconventional ... full field capable, all encompassing systems ... ever need to ensure the most ... also include the most important and ...
... II-i series is a wheelchair accessible, computerized ... field. ,By using SITA, the expert operating ... up to 70%. ,A patented aspherically shaped ... increase patient comfort while testing out to ...
... results. The Kowa AP-340 a new concept ... system of ultimate simplicity. Quick, comfortable procedure ... a compact, unique design profile weighing just ... features.The integration of CRT display and instrumentation ...
Medicine Products: