Navigation Links
Alzheimer's-like brain changes found in cognitively normal elders with amyloid plaques
Date:3/30/2011

Researchers using two brain-imaging technologies have found that apparently normal older individuals with brain deposits of amyloid beta the primary constituent of the plaques found in the brains of Alzheimer's disease patients also had changes in brain structure similar to those seen in Alzheimer's patients. Results of the study, which has received early online publication in the Annals of Neurology, may help identify individuals who could be candidates for therapies to prevent the development of dementia.

"Our findings support the theory that Alzheimer's disease begins many years before symptoms appear and that amyloid plaque is an early sign of this process," says Keith Johnson, MD, Massachusetts General Hospital (MGH) Imaging, senior author of the study. "We see that when amyloid deposits are present, even in cognitively normal individuals, the degenerative changes of Alzheimer's are underway. Long-term studies to track these changes and observe how they evolve are ongoing."

Definitive diagnosis of Alzheimer's disease requires finding amyloid plaques and neurofibrillary tangles in the brain at autopsy. In recent years it has been possible to detect amyloid in living brains by PET scanning with an imaging agent known as Pittsburgh Compound B (PiB). Plaques have been observed in the brains of apparently healthy individuals, as well as those with dementia, but whether the presence of plaques indicates the early stages of Alzheimer's disease is not yet known.

High-resolution magnetic resonance imaging studies have identified characteristic changes in brain structure thinning of key cortical regions and reduced volume of structures such as the hippocampus in persons with mild cognitive impairment, in individuals known to carry gene mutations that directly cause Alzheimer's disease and in diagnosed Alzheimer's patients. A recent study reported similar brain changes in some cognitively normal elders but did not dis
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Longer Breast-Feeding May Be Key to Bigger Brains
2. For potentially crippling dystonia, earlier deep brain therapy gets better, quicker results
3. Deciphering hidden code reveals brain activity
4. UNC physician-scientist receives grant to study breast cancer brain metastases
5. Brain Stimulation Might Help Stroke Patients With Swallowing Problems
6. UCSF, UC Berkeley join forces to advance frontier of brain repair
7. NeuroImage: Multiplexing in the visual brain
8. Steroid May Help Cut Pneumonia Risk After Brain Trauma
9. Bilingual neurons may reveal the secrets of brain disease
10. Rat Study Sheds Light on How Alcohol Affects Young Brain
11. Self-administered light therapy may improve cognitive function after traumatic brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... (PRWEB) August 23, 2014 2014 ... is a professional and in-depth research report on ... Glucose Meter information, including Glucose Meter definition, classification, ... industry overview. This research covers the international market ... industry analysis covering macroeconomic environment & economic situation ...
(Date:8/22/2014)... Today, Zane Benefits, the #1 Online ... Health Plans. , According to Zane Benefits, employers are ... lower the cost of healthcare without reducing coverage for ... however, can be confusing. , The new guide contains ... main types of ABHPs. It also explains the ...
(Date:8/22/2014)... NV (PRWEB) August 22, 2014 ... that is written by marketing experts for marketers to ... links has caught the attention of Shane Michaels, prompting ... with Internet marketing in any way knows that content ... in the industry,” reports Michaels. “But even though content ...
(Date:8/22/2014)... Sacramento, CA (PRWEB) August 22, 2014 Buying ... to an adult who is unsure about available coverage types ... now providing principal life insurance policy pricing to the public ... The use of this tool is free and is expected ... are available to the public throughout the U.S. The system ...
(Date:8/22/2014)... 22, 2014 Millennium Treatment Group has recently ... a high level of drug use among teenagers. The treatment ... drug addiction and work to minimize drug abuse. , America ... and drug addiction in history. According to the National ... million Americans aged 12 or older—or 9.2 percent of the ...
Breaking Medicine News(10 mins):Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 3Health News:My Writers: Review Exposes Online Source for Quality Marketing Content 2Health News:Principal Life Insurance Policies Now Quoted for Adults at Insurance Website Online 2Health News:Millennium Treatment Group Sees Increase in Marijuana Use Among Youth 2
... a 27% Increase in Revenues, DALLAS, Oct. 30 ... of Internet-based claims,processing solutions for the healthcare industry, today ... ended September 30, 2008., "We are pleased to ... Don Crosbie, chief executive officer of Claimsnet.,"The increase in ...
... Philips,Electronics (NYSE: PHG , AEX: PHI) today ... offer quick relief from seasonal mood-related,problems. With the ... affected,by the increased darkness and experience what is ... blues may include lethargy, lowered mood, problems,sleeping, carbohydrate ...
... Mylan Inc. (NYSE: MYL ),today announced that ... company has declared its quarterly dividend of $16.25 per,share ... a liquidation,preference of $1,000.00 per share) payable on Nov. ... of Oct. 31, 2008., Mylan Inc., which provides ...
... VIRGINIA BEACH, Va., Oct. 30, 2008 AMERIGROUP,Corporation (NYSE: ... in the,17th Annual Credit Suisse Healthcare Conference on November ... Company,s presentation, which begins Thursday,November 13 at 4:00 p.m. ... http://www.amerigroupcorp.com, on the investors, page. A replay will,be ...
... age of disease onset and nerve cell death , , ... genes may be linked to the most common form ... team, from Massachusetts General Hospital-MassGeneral Institute for Neurological Disease ... families with a history of the devastating neurological disorder. ...
... Oct. 30 WellPoint,s commercial marketing,team was awarded ... Association,(DMA) for its innovative campaign, "Ecosphere -- Simple ... International ECHO Awards competition is the only international,award ... creativity,strategy and response results., WellPoint,s campaign, conducted ...
Cached Medicine News:Health News:Claimsnet.com Reports Third Quarter 2008 Results 2Health News:Claimsnet.com Reports Third Quarter 2008 Results 3Health News:Philips Introduces New, Advanced Light Therapy Device to Offer Quick Relief from Winter Blues 2Health News:Philips Introduces New, Advanced Light Therapy Device to Offer Quick Relief from Winter Blues 3Health News:Scientists Spot 4 New Alzheimer's Genes 2Health News:WellPoint Awarded Prestigious International Marketing Award 2
(Date:8/22/2014)... Aug. 22, 2014  Mark Riccio, director of ... facility, is using the online crowd-funding platform Kickstarter ... imaging to researchers and would-be superheros everywhere: "for ... would YOU do if you had Superman,s X-ray ... and explorers everywhere, from elementary through high school ...
(Date:8/22/2014)...  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) today announced the ... common stock and warrants at a price of $10,000 ... to deducting underwriting discounts and commissions and offering expenses ... immediately separable and will be issued separately.  The shares ... The NASDAQ Stock Market under the ticker symbol "WGBS" ...
(Date:8/21/2014)... , Aug. 21, 2014  eRelevance Corporation ... company, announced today that it has completed integration ... solution for Plastic Surgery and Dermatology practices. ... more value to healthcare practices using Nextech," stated ... eRelevance Corporation. "Using information from the EMR we ...
Breaking Medicine Technology:Cornell's X-ray Imaging Lab Director Uses Kickstarter Campaign to "Democratize" Advanced 3D Imaging 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 3WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 4eRelevance Corporation Integrates with Nextech Electronic Medical Records 2
... WARREN, N.J., Jan. 17, 2012 Roka Bioscience announced ... AOAC Performance Tested Method(SM) certification from the ... was conducted by Silliker, Inc., as part of the ... The Roka Listeria Detection Assay runs on the ...
... Positron Corporation (OTCBB: POSC), a leading molecular imaging company ... to announce the acquisition of Manhattan Isotope Technology, LLC ... operations and retained all employees of MIT. In exchange, ... and earn-out consideration of $3,500,000 based on 20 percent ...
Cached Medicine Technology:Roka Bioscience Awarded AOAC-RI Certification for Roka Listeria Detection Assay 2Positron Finalizes Acquisition of Manhattan Isotope Technology, LLC 2Positron Finalizes Acquisition of Manhattan Isotope Technology, LLC 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: